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[Detection of melanoma metastases with Tc-99m-tetrofosmin].

AbstractAIM:
The aim of this study was to evaluate Tc-99m-tetrofosmin whole-body imaging in the detection of metastases in patients with malignant melanoma.
METHODS:
In 30 patients with suspected melanoma metastases we performed whole body imaging. After administration of about 600 MBq Tc-99m-tetrofosmin dynamic images up to 10 min were performed in 7 patients (1 image per 10 sec) to evaluate the optimal tracer uptake in the metastases. In all patients whole-body images were performed 5-10 min p.i. using an acquisition time of 5 min per image. The final diagnosis was confirmed by surgical histology in 30 lesions, by computertomography and clinical course in the remaining lesions.
RESULTS:
Out of 64 melanoma metastases 49 were detected using Tc-99m-tetrofosmin scintigraphy (49 rp., 15 fn.). The overall sensitivity for the detection of malignant lesions was 77%. Referring only to the lymph node metastases, the sensitivity was 87% (26 rp.; 4 fn.). The maximal tracer uptake was reached 1 min after injection, with a slow decrease in the following 10 minutes. The size of the lesions ranged between 0.5 and 7.0 cm and the T/B ratios between 1.3 and 3.0 (mean 1.88).
CONCLUSIONS:
Tc-99m-tetrofosmin whole body imaging is a simple and side-effectless method for the detection of melanoma metastases especially of lymph node metastases. The results are comparable to Tc-99m-sestamibi and Tl-201 scintigraphy.
AuthorsL Rettenbacher, J Koller, H Kässmann, G Galvan
JournalNuklearmedizin. Nuclear medicine (Nuklearmedizin) Vol. 39 Issue 4 Pg. 97-101 ( 2000) ISSN: 0029-5566 [Print] GERMANY
Vernacular TitleNachweis von Melanommetastasen mit Tc-99m-Tetrofosmin.
PMID10919159 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane
Topics
  • Adult
  • Aged
  • Brain Neoplasms (radionuclide imaging, secondary)
  • Female
  • Humans
  • Lymphatic Metastasis (radionuclide imaging)
  • Male
  • Melanoma (pathology, radionuclide imaging, surgery)
  • Middle Aged
  • Neoplasm Metastasis (radionuclide imaging)
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • Sensitivity and Specificity

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