Abstract | OBJECTIVE: METHOD: RESULTS: The production of these mediators was significantly inhibited by the introduction of NFkappaB decoy ODN compared with the effect of scrambled decoy ODN. Transfection of NFkappaB decoy ODN resulted in a significant inhibition of synovial cell proliferation as compared with that of scrambled decoy ODN. CONCLUSION: The results demonstrated in this study suggest the potential usefulness of NFkappaB decoy ODN for gene therapy of inflammatory synovitis of RA.
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Authors | T Tomita, H Takano, N Tomita, R Morishita, M Kaneko, K Shi, K Takahi, T Nakase, Y Kaneda, H Yoshikawa, T Ochi |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 39
Issue 7
Pg. 749-57
(Jul 2000)
ISSN: 1462-0324 [Print] England |
PMID | 10908694
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cell Adhesion Molecules
- Cytokines
- Interleukin-1
- NF-kappa B
- Oligodeoxyribonucleotides
- Transcription Factors
- Tumor Necrosis Factor-alpha
- Intercellular Adhesion Molecule-1
- Matrix Metalloproteinase 1
- Fluorescein-5-isothiocyanate
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Topics |
- Arthritis, Rheumatoid
(metabolism, pathology, therapy)
- Cell Adhesion Molecules
(biosynthesis)
- Cell Division
- Cytokines
(antagonists & inhibitors, biosynthesis)
- Enzyme-Linked Immunosorbent Assay
- Fluorescein-5-isothiocyanate
(metabolism)
- Genetic Therapy
(methods)
- Humans
- Intercellular Adhesion Molecule-1
(genetics, metabolism)
- Interleukin-1
(genetics, metabolism)
- Matrix Metalloproteinase 1
(metabolism)
- NF-kappa B
(metabolism, physiology)
- Oligodeoxyribonucleotides
(administration & dosage, genetics, pharmacology)
- Synovial Membrane
(metabolism, pathology)
- Transcription Factors
(metabolism, physiology)
- Transfection
- Tumor Necrosis Factor-alpha
(genetics, metabolism)
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