Cyclin E overexpression in transitional cell carcinoma of the bladder.

Abstract

We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin-biotin-peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlated with histological grade, Ki-67 LI and p27(Kip1) labeling index (LI). These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma.

• Authors: K Makiyama, M Masuda, Y Takano, M Iki, T Asakura, Y Suwa, S Noguchi, M Hosaka
• Journal: Cancer letters (Cancer Lett) Vol. 151 Issue 2 Pg. 193-8 (Apr 14 2000) ISSN: 0304-3835 [Print] Ireland
• PMID: 10738114 (Publication Type: Journal Article)

Chemical References

• Cell Cycle Proteins
• Cyclin E
• Ki-67 Antigen
• Microtubule-Associated Proteins
• Tumor Suppressor Proteins
• Cyclin-Dependent Kinase Inhibitor p27

Topics

• Carcinoma, Transitional Cell (chemistry, pathology)
• Cell Cycle Proteins
• Cyclin E (analysis)
• Cyclin-Dependent Kinase Inhibitor p27
• Humans
• Immunohistochemistry
• Ki-67 Antigen (analysis)
• Microtubule-Associated Proteins (analysis)
• Neoplasm Invasiveness
• Neoplasm Staging
• Tumor Suppressor Proteins
• Urinary Bladder Neoplasms (chemistry, pathology)