Streptavidin

A 60-kDa extracellular protein of Streptomyces avidinii with four high-affinity biotin binding sites. Unlike AVIDIN, streptavidin has a near neutral isoelectric point and is free of carbohydrate side chains.

Also Known As:

Networked: 1028 relevant articles (31 outcomes, 93 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Press, Oliver W: 16 articles (10/2017 - 05/2002)
2.	Lin, Yukang: 13 articles (10/2017 - 07/2005)
3.	Wilbur, D Scott: 12 articles (11/2016 - 05/2002)
4.	Pagel, John M: 10 articles (01/2015 - 04/2006)
5.	Gao, Jimin: 9 articles (01/2021 - 06/2006)
6.	Hamlin, Donald K: 9 articles (11/2016 - 05/2002)
7.	Hnatowich, Donald J: 8 articles (07/2012 - 03/2002)
8.	Rusckowski, Mary: 8 articles (07/2012 - 03/2002)
9.	Gopal, Ajay K: 7 articles (11/2016 - 02/2008)
10.	Green, Damian J: 7 articles (11/2016 - 09/2007)

Related Diseases

1.	Neoplasms (Cancer) 07/21/2010 - "In conclusion, the streptavidin nanoparticle under development in this laboratory was used effectively for multimodality imaging of tumor in mice by fluorescence and nuclear detection. " 01/01/2005 - "The results also interestingly demonstrate, however, that improved clearance agents capable of removing the lower affinity streptavidin-antibody conjugate are needed to achieve comparable specificity in tumor to blood or normal organ ratios." 01/01/1998 - "Improved intratumoral penetration of radiolabeled streptavidin in intraperitoneal tumors pretargeted with biotinylated antibody." 02/01/1993 - "Tumor levels were also lower with labeled streptavidin but, because of still lower levels in liver and blood, the tumor/normal tissue ratios were improved. " 10/01/2019 - "In this study, to compare the biological effect and significance of TRIM28 expression in ESCC, immunohistochemistry (streptavidin-perosidase, S-P) method was used firstly to examine the expression of TRIM28 in 136 cases of ESCC, 35 cases of high grade intraepithelial neoplasia (HGIN), 29 cases of low grade intraepithelial neoplasia (LGIN) and 37 cases of normal esophageal epithelium (NEE). "
2.	Infections 01/01/2023 - "Here, we genetically engineered bacteriophages to allow synthesis of a monomeric streptavidin during infection of the bacterial host. " 04/10/2009 - "Because our indirect immunofluorescent assay readily detected infection of both CD4(+) and CD8(+) lymphocytes, a triple labeling flow cytometric procedure was developed to quantify the individual lymphocytes infected in vivo with REV. Lymphocytes were gated with a biotinylated pan-leukocyte marker bound to streptavidin R-PE-Cy5. " 03/01/1996 - "The immune response evoked in mice after intraperitoneal infection of 30 micrograms of gal-streptavidin was decreased after PEG modification, as shown by lower antibody titres and a reduction in the number of mice that elicited an anti-gal-streptavidin response. " 05/01/1987 - "In early infection scanning electron microscopy and streptavidin immunoperoxidase staining showed marked predilection of cryptosporidia for the FAE. " 11/01/2004 - "Streptavidin accumulates at sites of inflammation and infection as a result of increased capillary permeability. "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2010 - "[Immobilization of streptavidin-tagged bioactive hTNF-alpha on biotinylated mucosal surface of the bladder wall for treatment of superficial bladder cancer in mice]." 05/01/2010 - "To investigate a novel immunotherapy through immobilization of streptavidin-tagged hTNF-alpha on the biotinylated mucosal surface of the bladder wall for bladder cancer treatment in mice. " 03/01/2012 - "We developed what is to our knowledge a novel technology by which streptavidin tagged mouse GM-CSF was displayed on the surface of biotinylated bladder cancer cells to induce antitumor immunity. " 10/01/2011 - "In the present study, we prepared streptavidin (SA)-tagged sCD40L and developed a novel immunotherapy for superficial bladder cancer based on the strong interaction between streptavidin and biotin. " 06/01/2010 - "A novel immunotherapy for superficial bladder cancer by the immobilization of streptavidin-tagged bioactive IL-2 on the biotinylated mucosal surface of the bladder wall."
4.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 12/15/2015 - "The self-assembled monolayer surface (SAMs) was used for immobilized streptavidin-biotinylated probes on the sensor surface for the detection of LAMP amplicons from MRSA. " 12/13/2007 - "Diffusion-limited loading of the biotinylated self-assembled monolayers (SAMs) ensures a precise control of the streptavidin surface density. " 01/01/2017 - "To address these questions, we study streptavidin (SAv) binding to commonly used biotinylated surfaces such as supported lipid bilayers (SLBs) and self-assembled monolayers (SAMs). " 05/04/2010 - "Many biosensor applications are based on streptavidin (SA) binding to partially biotinylated self-assembled thiol monolayers (SAMs). " 09/01/2008 - "These results can be applied to determine an optimal mixing ratio of MUOH and MBDA SAMs that reduces non-specific streptavidin binding onto a surface."
5.	Lymphoma (Lymphomas) 10/15/2001 - "This study assessed the ability of a streptavidin-biotin "pretargeting" approach to improve the biodistribution of radioactivity in mice bearing Ramos lymphoma xenografts. " 01/01/2005 - "Role of biotin-binding affinity in streptavidin-based pretargeted radioimmunotherapy of lymphoma." 12/01/2000 - "A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy." 01/01/2006 - "A phase I study of an anti-CD20/streptavidin pretargeting agent and 15 mCi/m(2)(90)Y-biotin produced objective responses with minimal toxicity among lymphoma patients, with an average tumor-to-whole-body radiation dose ratio of 49. " 10/01/2017 - "We evaluated pretargeting (i.e., multistep targeting) as a strategy to facilitate nanoparticle delivery to multiple target cells by measuring the uptake of biotinylated nanoparticles by lymphoma cells with distinct surface antigens pretreated with different bispecific streptavidin-scFv fusion proteins. "

Related Drugs and Biologics

1.	Biotin (Vitamin H)
2.	Proteins (Proteins, Gene)
3.	Monoclonal Antibodies
4.	Avidin
5.	Vaccines
6.	DOTA-biotin (90Y-DOTA-biotin)
7.	Single-Chain Antibodies
8.	Peroxidase (Myeloperoxidase)
9.	Antigens
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radioimmunotherapy
4.	Intravenous Administration
5.	Radiotherapy