Betacellulin

An EGF family member that plays an important role in regulating growth and differentiation of PANCREATIC BETA CELLS. Betacellulin has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR.

Networked: 87 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dahlhoff, Maik: 8 articles (03/2020 - 12/2005)
2.	Schneider, Marlon R: 8 articles (01/2020 - 12/2005)
3.	Wolf, Eckhard: 5 articles (08/2012 - 12/2005)
4.	Brandslund, Ivan: 4 articles (10/2020 - 01/2018)
5.	Olsen, Dorte Aalund: 4 articles (10/2020 - 01/2018)
6.	Bechmann, Troels: 3 articles (10/2020 - 11/2019)
7.	Kjær, Ina Mathilde: 3 articles (10/2020 - 11/2019)
8.	Madsen, Jonna Skov: 3 articles (10/2020 - 11/2019)
9.	Algül, Hana: 3 articles (03/2020 - 04/2010)
10.	Lesina, Marina: 3 articles (03/2020 - 04/2010)

Related Diseases

1.	Hyperglycemia 11/01/2015 - "Betacellulin ameliorates hyperglycemia in obese diabetic db/db mice." 11/01/2015 - "We found that administration of a recombinant adenovirus (rAd) expressing betacellulin (BTC) into obese diabetic db/db mice ameliorated hyperglycemia. " 02/01/2011 - "Betacellulin overexpression in mesenchymal stem cells induces insulin secretion in vitro and ameliorates streptozotocin-induced hyperglycemia in rats." 08/01/2008 - "Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice." 05/01/2011 - "Hydrodynamics-based transfection of the combination of betacellulin and neurogenic differentiation 1 DNA ameliorates hyperglycemia in mice with streptozotocin-induced diabetes."
2.	Glucose Intolerance 05/30/2014 - "Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice." 12/01/2000 - "Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion." 04/01/2007 - "To evaluate whether polymorphisms in this gene are associated with type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), we genotyped 7 previously identified betacellulin variants in Amish subjects with T2DM (n=150), IGT (n=148) and normal glucose tolerance (NGT) (n=361). "
3.	Wounds and Injuries (Trauma) 05/01/2014 - "Epidermal growth factor receptor ligands improved wound closure and activated EGFR, but betacellulin (BTC) was the most efficacious promoter of wound healing in vitro. " 11/01/2015 - "To this matter, we investigated by xMAP assay the dynamics of some angiogenic factors known to be involved in tissue repair, such as follistatin (FST), Placental Growth Factor-2 (PLGF-2), epidermal growth factor (EGF), betacellulin (BTC), and amphiregulin (AREG) using an animal model that mimics acute muscle contusion injuries. "
4.	Type 2 Diabetes Mellitus (MODY) 04/01/2005 - "Further studies will be needed to understand the different roles that betacellulin polymorphisms play in susceptibility to type 2 diabetes in Caucasians and African Americans." 04/01/2007 - "Betacellulin variants and type 2 diabetes in the Old Order Amish." 07/25/2006 - "We were unable to confirm a role for nonsynonymous variants of betacellulin in the propensity to type 2 diabetes or to impaired insulin secretion." 07/25/2006 - "Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects." 12/01/2005 - "A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes."
5.	Breast Neoplasms (Breast Cancer) 01/09/2009 - "Furthermore we show by differential competition with unlabeled NRG/YYDLL and betacellulin that the number of ErbB3 and ErbB4 receptors can be quantified separately on cultured human breast cancer cells." 01/01/2018 - "Prior to large studies in breast cancer patients and healthy individuals we established a sensitive three-plex immunoassay to measure the EGFR ligands amphiregulin (AR), betacellulin (BTC) and transforming growth factor α (TGF-α) simultaneously in human serum samples. " 09/30/2008 - "The expression of EGFR/ErbB-1 gene, an important predictor of outcome in breast cancer, was reduced together with the genes for betacellulin and amphiregulin, two known ligands of EGFR/ErbB receptors. " 10/06/2020 - "The study, which included 311 early-stage breast cancer patients, investigated associations between preoperative serum levels of EGFR and EGFR ligands (epidermal growth factor, heparin-binding epidermal growth factor (HBEGF), amphiregulin, transforming growth factor-α and betacellulin) and survival. " 01/01/2020 - "Pre-treatment serum samples were obtained from 311 women with newly diagnosed early-stage breast cancer and from 419 healthy women and analysed for EGFR and the ligands: Epidermal growth factor (EGF), heparin-binding epidermal growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), and transforming growth factor α (TGF-α). "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Ligands
3.	ErbB Receptors (EGF Receptor)
4.	DNA (Deoxyribonucleic Acid)
5.	Alloxan
6.	Amphiregulin
7.	Transforming Growth Factors (Transforming Growth Factor)
8.	Epidermal Growth Factor (EGF)
9.	Heparin (Liquaemin)
10.	Neuregulins

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Pancreatectomy