Linear IgA Bullous Dermatosis

Autoimmune disease characterized by subepidermal blisters and linear deposition of autoantibodies at the dermoepidermal junction. The accumulated autoantibodies are of IMMUNOGLOBULIN A and occasionally IMMUNOGLOBULIN G classes against epidermal BASEMENT MEMBRANE proteins. The dermatosis is sometimes associated with malignancies and use of certain drugs (e.g., VANCOMYCIN).

Also Known As:

Chronic Bullous Disease of Childhood; Drug-induced Linear IgA Bullous Dermatosis; Drug-induced Linear IgA Dermatosis; Linear IgA Dermatosis; Linear IgA IgG Bullous Dermatosis; Linear IgA IgG Dermatosis; Dermatoses, Linear IgA; Dermatosis, Linear IgA; Drug induced Linear IgA Bullous Dermatosis; Drug induced Linear IgA Dermatosis; IgA Dermatoses, Linear; IgA Dermatosis, Linear; Linear IgA Dermatoses

Networked: 343 relevant articles (7 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Benign Mucous Membrane Pemphigoid (Cicatricial Pemphigoid)
2.	Ulcerative Colitis
3.	Neoplasms (Cancer)
4.	Hemolytic Anemia
5.	Skin Diseases (Skin Disease)

Experts

1.	Hashimoto, Takashi: 17 articles (07/2021 - 01/2005)
2.	Ishii, Norito: 12 articles (07/2021 - 11/2013)
3.	Koga, Hiroshi: 7 articles (08/2020 - 11/2013)
4.	Hashimoto, T: 6 articles (11/2016 - 12/2000)
5.	Yamagami, Jun: 4 articles (09/2021 - 12/2017)
6.	Tsuruta, Daisuke: 4 articles (12/2020 - 08/2011)
7.	Ishii, N: 4 articles (07/2017 - 03/2013)
8.	Nishie, Wataru: 3 articles (09/2021 - 12/2017)
9.	Schmidt, Enno: 3 articles (08/2021 - 02/2012)
10.	Zillikens, Detlef: 3 articles (08/2021 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Linear IgA Bullous Dermatosis:

1.	Dapsone FDA Link 11/01/2020 - "Successful treatment of a patient with linear IgA bullous dermatosis limited to oral, hypopharyngeal, and laryngeal mucosa with dapsone." 04/25/2018 - "Previously misdiagnosed linear IgA dermatosis resolved with dapsone." 03/16/2011 - "At the previous hospital, she had been administered Dapsone for linear IgA bullous dermatosis. " 04/01/2003 - "A 74 year-old woman was treated with dapsone, 50 mg per day, for a linear IgA dermatosis. " 10/01/1990 - "Skin changes of linear IgA dermatosis responded to a combined treatment with dapsone and MOPP regimen. "
2.	Immunoglobulin A (IgA)IBA 04/01/2014 - "Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease, which is defined by the histopathological finding of subepidermal vesicles with neutrophilic infiltration and linear IgA deposits in the basement membrane zone, revealed by immunofluorescence study. " 01/01/1990 - "A case of linear IgA bullous dermatosis of childhood: immunoelectron microscopic and IgA subclass studies." 12/01/1984 - "[Immunoelectron microscopic study of IgA deposition in linear IgA bullous dermatosis]." 03/01/2023 - "Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease characterized by linear IgA deposition along the skin basal membrane. " 10/01/2022 - "Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease characterized by linear IgA deposition along the dermo-epidermal junction on direct immunofluorescence (DIF). "
3.	Floxacillin (Flucloxacillin)IBA 04/01/2006 - "We sought to assess the efficacy of flucloxacillin in the treatment of linear IgA bullous dermatosis. " 04/01/2006 - "This is an observational study in which all confirmed cases of linear IgA bullous dermatosis (by both histological and immunofluorescence studies) will be treated with flucloxacillin. " 04/01/2006 - "We describe 7 patients with linear IgA bullous dermatosis of childhood treated with flucloxacillin. " 04/01/2006 - "Treatment of linear IgA bullous dermatosis of childhood with flucloxacillin." 04/01/2006 - "Flucloxacillin may be considered among the first alternative therapies for linear IgA bullous dermatosis of childhood. "
4.	SteroidsIBA 03/01/2020 - "We report an extremely rare case of linear IgA dermatosis in a child who was postrenal transplant and treated successfully with dapsone and steroids." 11/01/2021 - "Patients with chronic bullous disease of childhood (CBDC) generally respond well to treatment with drugs like Dapsone and oral and topical steroids. " 03/01/2019 - "The therapy of linear IgA dermatosis is ensured by steroid-containing topical agents, alongside antiseptic measures as well as systemic dapsone p.o."
5.	Colchicine FDA LinkGeneric 10/01/2006 - "[Linear IgA bullous dermatosis of adults treated with colchicine]." 03/01/2000 - "Treatment of linear IgA bullous dermatosis of childhood with colchicine: in reply." 01/01/1999 - "Treatment of linear IgA bullous dermatosis of childhood with colchicine." 01/01/1999 - "We recommend colchicine as an alternative therapy for linear IgA dermatosis of childhood in patients in whom first-line treatment is contraindicated or who fail first-line treatment or develop side effects from it." 01/01/1999 - "We report a child with linear IgA dermatosis who was treated successfully with colchicine after developing hemolytic anemia from dapsone. "
6.	Erythromycin (Erycette)FDA LinkGeneric 07/01/2008 - "These results suggest that erythromycin is unlikely to produce sustained improvement in chronic bullous disease of childhood when used as a sole first-line agent. " 07/01/2008 - "Is erythromycin an effective treatment for chronic bullous disease of childhood? " 07/01/2008 - "A three question survey was e-mailed to all members of the British Society for Paediatric Dermatology to assess the incidence, preferred treatments and experience of oral erythromycin in treating chronic bullous disease of childhood. " 02/01/2023 - "A case of linear IgA bullous dermatosis in a glucose-6-phosphate dehydrogenase-deficient child successfully treated with oral erythromycin and topical tacrolimus."
7.	SalazopyrineIBA 04/01/2003 - "After surgical resection of the tumor, remission of linear IgA dermatosis was obtained with salazopyrine. "
8.	AutoantibodiesIBA 04/01/1996 - "This study characterizes a novel basement membrane component that is the target of autoantibodies in patients with linear IgA bullous dermatosis. " 01/01/2020 - "Linear IgA/IgG bullous dermatosis with autoantibodies directing the native and processed forms of BP180." 03/01/2015 - "A case of linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies." 03/01/2002 - "Autoimmune responses in patients with linear IgA bullous dermatosis: both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule." 01/01/1992 - "Linear IgA dermatosis is an autoantibody-mediated, subepidermal blistering disease that is rarely associated with drug exposure. "
9.	Vancomycin FDA LinkGeneric 01/01/2022 - "Vancomycin-induced linear IgA bullous dermatosis." 10/15/2020 - "Vancomycin-Induced Linear IgA Bullous Dermatosis." 08/26/2020 - "Linear IgA bullous dermatosis (LABD) can be a cutaneous side effect of commonly used inpatient medications, such as vancomycin. " 08/26/2020 - "Vancomycin-induced linear IgA bullous dermatosis." 11/01/2019 - "Unilateral vancomycin-induced linear IgA bullous dermatosis."
10.	AntigensIBA 09/01/2015 - "Since the original description by Zone et al in 1994, the disease entity and target antigens in linear IgA/IgG bullous dermatosis (LAGBD) have not been clarified in 20 years. " 05/01/2011 - "A Case of Chronic Bullous Disease of Childhood That Was Reactive to the Antigen of 120 kDa (LAD-1)." 04/01/1996 - "97-kDa linear IgA bullous dermatosis (LAD) antigen localizes to the lamina lucida of the epidermal basement membrane." 11/01/1994 - "Immunogold localization of the 97-kD antigen of linear IgA bullous dermatosis (LABD) detected with patients' sera." 09/01/1987 - "This suggests that in linear IgA bullous dermatosis the antibody reacts with the antigen in the sublamina densa region of the basement membrane zone."

Therapies and Procedures

1.	Therapeutics 09/01/1999 - "The therapies for linear IgA bullous dermatosis of childhood." 06/01/2013 - "We review the pathogenesis, clinical features, diagnosis, differential diagnosis, and therapy of autoimmune bullous skin diseases of childhood, especially of the most common linear IgA dermatosis. " 01/01/1999 - "We recommend colchicine as an alternative therapy for linear IgA dermatosis of childhood in patients in whom first-line treatment is contraindicated or who fail first-line treatment or develop side effects from it." 08/01/2021 - "Linear IgA/IgG bullous dermatosis after nivolumab therapy." 10/18/2020 - "A Case of Linear IgA Bullous Dermatosis Induced by Aspirin Therapy."
2.	Colectomy 07/01/2013 - "Linear IgA dermatosis associated with ulcerative colitis: complete and sustained remission after total colectomy."
3.	Gluten-Free Diet 06/01/2001 - "Linear IgA bullous dermatosis responsive to a gluten-free diet." 09/01/1986 - "The control sera provided by the four centers included the sera of nineteen patients with dermatitis herpetiformis and two with celiac disease who were on a gluten-free diet, the sera of five normal subjects with human lymphocyte antigens (B8 locus), the sera of thirteen patients with linear IgA bullous dermatosis, and fifty-eight other control sera, mostly from patients with other bullous diseases and other dermatoses. "
4.	Restorative Proctocolectomy 11/01/2009 - "Linear IgA bullous dermatosis and ulcerative colitis treated by proctocolectomy."
5.	Liver Transplantation 06/01/2022 - "Linear IgA bullous dermatosis with Koebner phenomenon in a liver transplant patient."