HLA-G Antigens (HLA G)

Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.

Also Known As:

HLA G; HLA-G; HLA-G Antigen; HLA-G1; HLA-G1 Isoform; HLA-G2; HLA-G2 Isoform; HLA-G3; HLA-G3 Isoform; HLA-G4; HLA-G4 Isoform; HLA-G5; HLA-G5 Isoform; HLA-G6; HLA-G6 Isoform; HLA-G7; HLA-G7 Antigen; HLA-G7 Isoform; Antigen, HLA-G; Antigen, HLA-G7; Antigens, HLA-G; HLA G Antigen; HLA G Antigens; HLA G1 Isoform; HLA G2 Isoform; HLA G3 Isoform; HLA G6 Isoform; HLA G7 Antigen; HLA G7 Isoform; Isoform, HLA-G4; Isoform, HLA-G6; Isoform, HLA-G7

Networked: 1252 relevant articles (22 outcomes, 330 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carosella, Edgardo D: 69 articles (05/2022 - 02/2002)
2.	Rizzo, Roberta: 53 articles (01/2022 - 09/2003)
3.	Moreau, Philippe: 46 articles (05/2021 - 01/2003)
4.	Rouas-Freiss, Nathalie: 41 articles (05/2022 - 02/2002)
5.	Yan, Wei-Hua: 36 articles (08/2022 - 09/2009)
6.	Lin, Aifen: 31 articles (08/2022 - 09/2009)
7.	Bortolotti, Daria: 29 articles (01/2022 - 11/2012)
8.	Donadi, Eduardo A: 28 articles (01/2022 - 06/2009)
9.	Hviid, Thomas Vauvert F: 27 articles (01/2022 - 05/2003)
10.	Rebmann, Vera: 24 articles (01/2021 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Moreover, high tumor expression of PD-L1 (p = 0.002), Gal-9 (p = 0.003), HVEM (p = 0.001), IDO (p = 0.049), HLA-G (p = 0.004) and high CD8/FoxP3 TIL ratio (p = 0.006) were associated with improved cancer-specific survival. " 01/19/2018 - "Strategies that modulate HLA-G expression in the tumor microenvironment may enhance the efficacy of cellular immunotherapeutics in this cancer." 11/01/2014 - "Interestingly, although hβ2m+ HLA-G5- tumors were rejected, secreted HLA-G5 provided hβ2m+ HLA-G5+ tumors a protection against hβ2m-elicited immune rejection, enabling such immunogenic tumors to grow similarly to a poorly immunogenic tumor. " 08/01/2023 - "This study aims for HLA-G expression in the bladder TC in a public hospital in Argentina linking its malignancy grade with the survival of the patients. " 01/01/2023 - "Overall long-term survival, long-term survival free of late graft failure and cancer-free survival were not significantly different in patients with an AUC of s-HLA-G levels higher or lower than the median of the study population. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "In addition, it is also necessary to unravel the mechanisms underlying HLA-G/KIR2DL4 regulation of the immune microenvironment in breast cancer, hopefully providing a rationale for combined HLA-G and immune checkpoints targeting for the effective treatment of breast cancer." 08/01/2020 - "The findings of the present study suggest that the HLA-G 14-bp Ins/Del polymorphism could influence breast cancer pathogenesis among South Indian women." 11/01/2019 - "The aim of this study was to determine the possible associations of soluble HLA-G and HLA-G +3142G/C SNP with breast cancer. " 04/01/2016 - "In this study, we explored levels of soluble HLA-G (sHLA-G) in plasma samples obtained from women with breast cancer (BC). " 01/01/2015 - "This finding highlights the necessity of future studies of this gene to establish the exact role of HLA-G in progression steps of breast cancer."
3.	Carcinoma (Carcinomatosis) 01/01/2014 - "HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas." 04/01/2013 - "In this study, we found that HLA-G expression could dramatically decreased the NK cytotoxicity against the ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G), and matrix metalloproteinase-15 (MMP-15) expression was up-regulated in HO-8910-G cells. " 07/01/2012 - "In the current study, ovarian carcinoma cell lines (HO-8910 and Ovcar-3) were transfected with HLA-G gene. " 08/01/2023 - "HLA-G expression in transitional bladder carcinoma. " 07/31/2021 - "Overall, HLA-G expression did not univocally result in poor clinical outcome of carcinoma patients. "
4.	Autoimmune Diseases (Autoimmune Disease) 01/01/2016 - "LD was detected between DRB113:02, protective against multiple autoimmune diseases in the Japanese, and the rs1063320 G (D' = 0.86, r2 = 0.02) and with 14bp del (D' = 0.62, r2 = 0.01), but not between SLE-susceptible DRB115:01 and HLA-G. " 01/01/2022 - "Also, in recent years, several studies have shown that HLA-G plays an important role in the control of autoimmune diseases. " 08/01/2014 - "Several recent studies have provided evidence that a 14 bp insertion (INS)/deletion (DEL) polymorphism in the HLA-G gene might be associated with autoimmune disease. " 10/01/2010 - "The nonclassical human leucocyte antigen (HLA)-G molecule has been well recognized as a tolerogenic molecule and few studies have evaluated the role of the molecule in inflammatory cutaneous autoimmune diseases. " 05/01/2023 - "Polymorphisms in HLA-G are associated with several autoimmune diseases including T1D. "
5.	Infections 01/01/2023 - "This study describes new information concerning placental HLA-G alleles in women from southern Brazil and helps explain how genetic background can modify susceptibility to placental infections." 01/01/2017 - "The results from our study suggest a possible involvement of HLA-G in the risk modulation toward HCV infection." 09/01/2016 - "This review will discuss different steps in the study of HLA-G expression and functions in vivo, starting with analyses of expression of the HLA-G gene and its receptors in transgenic mice, and continuing with applications of HLA-G and its receptors in prevention of allograft rejection, transplantation tolerance, and controlling the development of infection. " 08/01/2014 - "In this study, we investigated the influence of HLA-G 14 bp (rs66554220) and +3142 (rs1063320) polymorphisms in 179 women with active human papillomavirus (HPV) infection and 143 age-matched, unrelated, HPV-negative, normal Chinese Han population. " 01/02/2013 - "In this study, we used a sequence-based typing method to genotype HLA-G for 667 women enrolled in this cohort and examined the influence of HLA-G genotypes on resistance or susceptibility to HIV-1 infection. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	HLA-G Antigens (HLA G)
3.	HLA Antigens (Human Leukocyte Antigens)
4.	3' Untranslated Regions (3' UTR)
5.	Interleukin-10 (Interleukin 10)
6.	Messenger RNA (mRNA)
7.	Antibodies
8.	Small Interfering RNA (siRNA)
9.	Trastuzumab (Herceptin)
10.	Progesterone

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Immunotherapy
4.	Kidney Transplantation
5.	Organ Transplantation