Intra-Abdominal Hypertension

Pathological elevation of intra-abdominal pressure (>12 mm Hg). It may develop as a result of SEPSIS; PANCREATITIS; capillary leaks, burns, or surgery. When the pressure is higher than 20 mm Hg, often with end-organ dysfunction, it is referred to as abdominal compartment syndrome.

Also Known As:

Intraabdominal Hypertension; Abdominal Compartment Syndromes; Compartment Syndrome, Abdominal; Compartment Syndromes, Abdominal; Hypertension, Intra-Abdominal; Hypertension, Intraabdominal; Hypertensions, Intra-Abdominal; Hypertensions, Intraabdominal; Intra Abdominal Hypertension; Intra-Abdominal Hypertensions; Intraabdominal Hypertensions; Syndrome, Abdominal Compartment; Syndromes, Abdominal Compartment; Abdominal Compartment Syndrome

Networked: 851 relevant articles (39 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Intra-Abdominal Hypertension
2.	Pancreatitis
3.	Sepsis (Septicemia)
4.	Liver Diseases (Liver Disease)
5.	Critical Illness (Critically Ill)

Experts

1.	Kirkpatrick, Andrew W: 14 articles (01/2020 - 01/2006)
2.	Malbrain, Manu L N G: 12 articles (01/2021 - 07/2003)
3.	Moore, Frederick A: 12 articles (01/2017 - 12/2002)
4.	Cheatham, Michael L: 12 articles (12/2011 - 02/2004)
5.	Ball, Chad G: 11 articles (01/2017 - 01/2006)
6.	Moore, Ernest E: 10 articles (01/2018 - 10/2003)
7.	Starkopf, Joel: 9 articles (10/2021 - 01/2008)
8.	Leppäniemi, Ari: 9 articles (02/2014 - 08/2005)
9.	Regli, Adrian: 8 articles (01/2022 - 01/2010)
10.	De Waele, Jan J: 8 articles (01/2018 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intra-Abdominal Hypertension:

1.	Interleukin-8 (Interleukin 8)IBA 06/01/2007 - "Plasma concentration of IL-8 was elevated in intra-abdominal hypertension patients 3 days postburn. " 01/01/2017 - "Early Continuous Veno-Venous Hemofiltration Is Effective in Decreasing Intra-Abdominal Pressure and Serum Interleukin-8 Level in Severe Acute Pancreatitis Patients with Abdominal Compartment Syndrome." 01/01/2017 - "The aim of this study was to evaluate the efficacy of early continuous veno-venous hemofiltration (CVVH) in decreasing the intra-abdominal pressure (IAP) and serum interleukin-8 (IL-8) level in severe acute pancreatitis (SAP) patients with abdominal compartment syndrome (ACS). " 06/01/2007 - "Intra-abdominal hypertension induced acute lung injury and MODS with IL-8 elevation, even though AD improved hemodynamic parameters in extensively burned patients."
2.	Crystalloid SolutionsIBA 01/01/2023 - "Primary fascial closure rates may be improved by early return to the operating room; limiting use of crystalloid fluids during the surgical interval; and preventing and/or treating intra-abdominal hypertension, enteric fistulae, and intra-abdominal collections after surgery. " 02/01/2014 - "The conjoint effect of reduced crystalloid administration and decreased damage-control laparotomy use in the development of abdominal compartment syndrome." 04/01/2010 - "Contemporary resuscitation strategies may exacerbate intraabdominal hypertension, particularly massive crystalloid resuscitation. " 10/19/2016 - "In the absence of any direct abdominal trauma, we observed a rapidly evolving secondary abdominal compartment syndrome shortly after hospital admittance associated with massive transfusion of blood products and only moderate crystalloid resuscitation. " 01/01/2007 - "Secondary abdominal compartment syndrome developed in this pediatric trauma patient with hemorrhagic shock, possibly from aggressive crystalloid resuscitation. "
3.	Anesthetics (Anesthetic Agents)IBA 08/01/1997 - "Recent insights into the physiologic effects of the intra-abdominal compartment syndrome have improved anesthetic care as well. " 04/01/2004 - "Laparoscopic kidney donation does not require a particularly complex or expensive anesthetic management or approach; as it has been suggested that intra-abdominal hypertension coming from CO(2) insufflation inside the donor's peritoneal cavity may threaten graft function, during laparoscopic kidney donation it is advisable to adopt a strategy for "renal protection." Thus, when a laparoscopic kidney donation is performed at our center, a multidisciplinary approach is commonly adopted based on three key points: perioperative positive volemic balance in donors; intraoperative urinary output of at least 100 mL/h; inflation with an abdominal pressure not exceeding 12 mm Hg." 09/01/2007 - "[Intensive care and anesthetic maintenance in intra-abdominal hypertension]." 10/01/2022 - "In this case report, we describe the effects of chronic abdominal compartment syndrome in an infant due to a solid renal tumor and its anesthetic implications." 04/01/2015 - "As the incidence of eating disorders is increasing, anesthesiologists should keep in mind the possibility of abdominal compartment syndrome in patients with a recent history of binge eating, and prepare optimal anesthetic and resuscitation remedies against sudden deteriorations of a patient's condition. "
4.	MelatoninIBA 10/01/2003 - "Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats." 01/01/2016 - "However, the salutary effect of melatonin against secondary intra-abdominal hypertension (IAH) remains unclear. " 01/01/2016 - "Melatonin prevents secondary intra-abdominal hypertension in rats possibly through inhibition of the p38 MAPK pathway." 01/01/2016 - "Comparison of Melatonin, Hypertonic Saline, and Hydroxyethyl Starch for Resuscitation of Secondary Intra-Abdominal Hypertension in an Animal Model."
5.	BPC 157IBA 01/01/2021 - "In conclusion, BPC 157 cured primary abdominal compartment syndrome." 01/01/2021 - "Rats with intra-abdominal hypertension (grade III, grade IV) received BPC 157 (10 µg or 10 ng/kg sc) or saline (5 ml) after 10 min. " 11/02/2023 - "Stable Gastric Pentadecapeptide BPC 157 Therapy: Effect on Reperfusion Following Maintained Intra-Abdominal Hypertension (Grade III and IV) in Rats." 01/01/2021 - "Corrigendum: Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats." 01/01/2021 - "Stable Gastric Pentadecapeptide BPC 157 Therapy for Primary Abdominal Compartment Syndrome in Rats."
6.	Neostigmine (Neostigmine Bromide)IBA 01/01/2022 - "Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis." 11/01/2019 - "We report three children (9 months, 3 years, and 12 years old) who developed refractory ileus after liver transplant, with one of them developing abdominal compartment syndrome, who were treated successfully with continuous infusions of neostigmine. "
7.	tetraethylpyrazine (TEP)IBA 01/01/2010 - "Utilisation of TEP is associated with significant reductions of cardiac dysfunction and development of abdominal compartment syndrome, as well as, significant improvement in 30-day survival." 01/01/2010 - "Occurrence of cardiac dysfunction and abdominal compartment syndrome was significantly lower in TEP patients who survived 24-h post-injury (both p < or = 0.04). " 01/01/2009 - "There was no difference in renal failure or systemic inflammatory response syndrome, but pneumonia, pulmonary failure, open abdomens, and abdominal compartment syndrome were lower in TEP. "
8.	Polymethyl Methacrylate (Sol)IBA 08/01/2005 - "Management of intra-abdominal hypertension in patients with severe acute pancreatitis with continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter." 08/01/2005 - "To evaluate, with a prospective observational study, whether continuous hemodiafiltration using a polymethyl methacrylate membrane hemofilter (PMMA-CHDF) is effective for prevention and treatment of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) on patients with severe acute pancreatitis (SAP). "
9.	Pipecuronium (Pipecuronium Bromide)FDA Link 01/01/2017 - "Pipecuronium bromide have lowered IAP by 33.4%, witnessing efficacy of application of myorelaxants in treatment of intraabdominal hypertension in purulent pancreatitis."
10.	Carboplatin (JM8)FDA LinkGeneric 06/08/2023 - "After chemotherapy using carboplatin and etoposide, the infiltrative massive hepatic invasion was resolved and the abdominal compartment syndrome gradually improved; however, liver dysfunction as evidenced by hyperbilirubinemia, coagulopathy, and hyperammonemia continued. "

Therapies and Procedures

1.	Resuscitation 01/01/2009 - "It is now recognized that resuscitation to achieve supranormal indices is not beneficial in all patients and may precipitate abdominal compartment syndrome. " 01/01/2017 - "Additional studies are needed to better characterize the optimal fluid resuscitation strategy, as well as the importance of intra-abdominal hypertension as an early therapeutic target. " 12/01/2023 - "To determine whether decreasing fluid resuscitation volume in a burn center reduced the incidence of abdominal compartment syndrome. " 12/01/2023 - "Reducing the volume of fluids given during resuscitation may reduce the incidence of abdominal compartment syndrome and improve outcomes. " 01/01/2020 - "Abdominal compartment syndrome is caused by excessive pressure within the abdominal compartment due to diminished abdominal wall compliance, increased intraluminal contents, increased abdominal contents, or capillary leak/fluid resuscitation. "
2.	Critical Care (Surgical Intensive Care) 02/01/2017 - "Intra-abdominal high pressure is an entity that can have serious impact on intensive care admitted patients, studies concluding that if this condition progresses to abdominal compartment syndrome mortality is as high as 80%. " 09/01/2016 - "This study aimed to investigate the incidence and prognostic factors of mortality in intra-abdominal hypertension that developed during admission in the surgical intensive care units in Thailand. " 03/19/2014 - "In a recent issue of Critical Care, Cheng and colleagues conducted a rabbit model study that demonstrated that intra-abdominal hypertension (IAH) may damage both gut anatomy and function. " 01/01/2023 - "Intraabdominal hypertension (IAH) is negative for outcome after intensive care. " 06/01/2021 - "The Abdominal Compartment Society (WSACS) developed a medical management algorithm with a stepwise approach to keep intra-abdominal pressure (IAP) ≤ 15 mm Hg. The role of point-of-care ultrasound (POCUS) as a bedside modality in the critical care patients is not well studied in relation to the intra-abdominal hypertension (IAH) management algorithm. "
3.	Decompression 04/01/2013 - "Well-timed decompression in a porcine model of SAP incorporating 25-mm Hg intra-abdominal hypertension/ACS was associated with significantly reduced mortality, improved systemic hemodynamics and organ function, as well as alleviated histologic injury and inflammatory intensity. " 05/01/2001 - "In the absence of good outcome data, expert consensus is that an acute increase of IAP to above 20 to 25 mmHg and/or evidence of abdominal compartment syndrome warrants urgent decompression. " 09/01/2003 - "[Efficacy of decompression treatment of abdominal compartment syndrome]." 04/01/2014 - "The aim of this study was to investigate the abdominal metabolic response and circulatory changes after decompression of intra-abdominal hypertension in a porcine model. " 01/01/2023 - "The intra-abdominal compartment syndrome followed by emergency decompression surgery was present in one fourth of the patients. "
4.	Therapeutics 04/10/2015 - "The purpose of this study was to analyze the therapy of a severe abdominal compartment syndrome (ACS) to elucidate the use of an abdominal advanced flap with other supportive measures for restoration of large defects of the abdominal wall. " 11/01/2021 - "If it is accompanied by the occurrence of abdominal compartment syndrome (ACS) and does not respond to medical therapy, surgical intervention is indicated. " 12/01/2017 - "Abdominal compartment syndrome (ACS) is rare but has to be diagnosed to initiate a dedicated therapy. " 01/01/2017 - "No acute complications related to the NPWT-I. All patients presenting with abdominal compartment syndrome resolved after initiation of the NPWT-I. A total of 46 patients (96%) patients achieved fascia closure after NPWT-I therapy after an average of 6days. " 02/02/2016 - "He later developed abdominal compartment syndrome, despite cessation of thrombolytic and anticoagulation therapy. "
5.	Laparotomy 09/01/2010 - "By using decompressive laparotomy for abdominal compartment syndrome and leaving the abdomen open temporarily for other acute processes, survival in some instances may be improved. " 05/01/2015 - "The aim of this study was to compare the characteristics of patients who developed high-grade intra-abdominal hypertension (IAH) (i.e., grade III or IV; intra-abdominal pressure, IAP >20 mm Hg) following an injury-related laparotomy versus those who did not (i.e., IAP ≤20 mm Hg). " 01/01/2015 - "The aim of this study was to determine the prevalence, incidence and outcome of intra-abdominal hypertension among patients undergoing emergency laparotomy. " 10/01/2010 - "The aims of the study were to assess, in patients undergoing emergency laparotomy, whether intra-abdominal pressure (IAP) is an independent predictor of morbidity and mortality, to evaluate the effects of IAH, and to identify hidden cases of abdominal compartment syndrome (ACS). " 11/21/2023 - "Abdominal compartment syndrome was diagnosed and treated by decompressive laparotomy. "