NO-Donation Increases Visceral Circulation in a Porcine Model of Abdominal Hypertension.

Abstract

Intraabdominal hypertension (IAH) is negative for outcome after intensive care. Little research has focused on medical intervention to improve visceral circulation during IAH. A nitric oxide (NO)-donor was compared with placebo in 25 pigs; each pig was randomized into three groups: PDNO (NO-donor), Control (placebo), or Sham. IAH was induced by CO2 insufflation to 30 mmHg. Sham group had surgical preparation only. Blood gases, invasive venous and arterial blood pressure, intestinal microcirculation and superior mesenteric blood flow were measured. The PDNO group had significantly increased intestinal microcirculation compared with Controls during IAH (last hour, P = 0.009). The mean arterial pressure and abdominal perfusion pressures (APP) were decreased, and the cardiac index were increased in the PDNO group. Also, systemic and pulmonary vascular resistances were lower in the PDNO group compared with Controls. These experimental findings indicate that NO should be further explored with potential application to improve intestinal microcirculation in IAH patients.

• Authors: Per Skoog, Jenny Seilitz, Ioannis Oikonomakis, Tal M Hörer, Kristofer F Nilsson
• Journal: Journal of cardiovascular translational research (J Cardiovasc Transl Res) Vol. 16 Issue 1 Pg. 42-50 (02 2023) ISSN: 1937-5395 [Electronic] United States
• PMID: 36036860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Nitric Oxide

Topics

• Animals
• Hypertension
• Intra-Abdominal Hypertension
• Nitric Oxide
• Swine
• Vascular Resistance