|1.||Clevers, Hans: 24 articles (03/2010 - 02/2002)|
|2.||Brabletz, Thomas: 22 articles (03/2015 - 06/2002)|
|3.||Moon, Randall T: 22 articles (09/2010 - 02/2003)|
|4.||Taketo, Makoto M: 21 articles (09/2010 - 01/2002)|
|5.||Fearon, Eric R: 21 articles (05/2010 - 03/2002)|
|6.||Nosho, Katsuhiko: 20 articles (04/2011 - 09/2006)|
|7.||Hirohashi, Setsuo: 20 articles (09/2009 - 04/2002)|
|8.||Ogino, Shuji: 17 articles (04/2011 - 07/2007)|
|9.||Tanaka, Takuji: 17 articles (07/2010 - 09/2002)|
|10.||Ben-Ze'ev, Avri: 17 articles (06/2010 - 07/2002)|
12/01/2008 - "Immunohistochemical analysis demonstrated significantly greater beta-catenin accumulation in pyloric tumors, compared with those in the fundus (P < 0.01) with mutations of exon 3; 18.2% and 31.6% in MNU-alone and MNU + H. "
10/15/2006 - "Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector."
12/01/2005 - "RT-PCR analysis successfully confirmed the presence of both beta-catenin splice variants in histologically normal and preneoplastic squamous epithelium, and invasive tumors of the esophagus, and identified a significant reduction in the 16A/16B ratio (P = 0.014) and an accompanying significant increase in the MYC/WAF1 expression ratio (P = 0.001) with progression from normal mucosa to dysplasia. "
05/01/2007 - "Taken together, these data demonstrate the efficacy of disrupting the beta-catenin/TCF transcriptional complex to exploit tumor dependence on Wnt signaling as a therapeutic approach in the treatment of MM."
08/01/2008 - "Inhibitors of the Tcf/beta-catenin complex may prove useful in the treatment of adrenocortical tumors in which multiple genetic alterations have accumulated."
|2.||Colorectal Neoplasms (Colorectal Cancer)
07/01/2010 - "Increasing beta-catenin expression in the cytoplasm was associated with improved survival for colorectal cancer cases on both univariate (P = 0.003) and multivariate (P = 0.01) analysis. "
06/01/2008 - "Our study identifies DACT3 as an important regulator of Wnt/beta-catenin signaling in colorectal cancer and suggests a potential strategy for therapeutic control of Wnt/beta-catenin signaling in colorectal cancer."
01/01/2008 - "Further studies on Wnt/beta-catenin and MMP-7 gene activity and protein expression are necessary to better understand the pathogenesis of colorectal carcinoma."
01/01/2008 - "To study the dynamic events leading to impaired cell-cell adhesion upon transition to the invasive phenotype of colorectal cancer (CRC), we examined three distinct beta-catenin expression patterns (membranous, cytoplasmic, and nuclear) in the paired samples of the primary tumours (P) and their metastatic lesions (M). "
05/01/2007 - "L1, a new target gene for Wnt/beta-catenin-TCF signaling, has been identified in the invasive front of colorectal cancer cells in vitro study. "
08/01/2008 - "Min mice treated systemically with beta-catenin AODNs over a 6-week period had a statistically significant reduction in the number of intestinal adenomas. "
08/01/2008 - "ANALYSIS OF beta-CATENIN PROTEIN EXPRESSION IN LIVER TISSUE AND INTESTINAL ADENOMAS: Adenomas harvested from mice treated for 7 days with beta-catenin AODNs demonstrated clear downregulation of beta-catenin expression, which was accompanied by a significant reduction in proliferation. "
06/04/2007 - "However, nuclear beta-catenin expression was significantly greater in MCRA patients' tumours than in sporadic adenomas. "
04/01/2009 - "This study was performed to characterize the clinicopathological features and examine activation of the Wnt/beta-catenin pathway in LSTs and protruded-type colorectal adenomas (PAs). "
08/01/2008 - "These studies provide direct evidence that targeted suppression of beta-catenin inhibits the formation of intestinal adenomas in APC-mutant mice. "
01/01/2014 - "These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed."
09/01/2011 - "In this study, we used lentivirus-mediated RNA interference (RNAi) targeted against beta-catenin to determine the effects of decreasing the high constitutive level of this protein in human tongue carcinoma cell line Tca8113. "
04/01/2006 - "Study of phospho-beta-catenin subcellular distribution in invasive breast carcinomas in relation to their phenotype and the clinical outcome."
10/01/2004 - "Recent studies have associated PTEN mutations with tumorigenesis of prostate carcinoma via the Wnt signaling pathway, leading to nuclear beta-catenin accumulation. "
04/30/2004 - "Recent studies have revealed the presence of beta-catenin mutations in a small subset of human and rat lung carcinomas, suggesting the involvement of the Wnt pathway in pulmonary carcinogenesis. "
|5.||Neoplasm Metastasis (Metastasis)
01/01/2011 - "The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis. "
08/01/2015 - "The abnormal expression rates of Tcf4 and beta-catenin were also related to the lymph node metastasis and Dukes stage (P<0.05). "
12/01/2014 - "Nek2 and beta-catenin expression were examined by immunohistochemistry in a series of resected CRC, as well as their matched lymph node and liver metastases, and correlated with clinicopathological characteristics. "
01/01/2014 - "The main effector of the Wnt signaling, beta-catenin, was up-regulated in 56%, and transferred to the nucleus in 36% of metastases. "
07/01/2011 - "The main effector of the wnt signaling, beta-catenin, was upregulated in 42.9% of cases and transferred to the nucleus in 28.6% of metastasis cases. "
|3.||Messenger RNA (mRNA)
|4.||glycogen synthase kinase 3 beta
|5.||Transcription Factors (Transcription Factor)
|6.||Glycogen Synthase Kinases
|10.||1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)
|1.||Drug Therapy (Chemotherapy)