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14-3-3 Proteins (14-3-3 Protein)

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A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Also Known As:

14-3-3 Protein; 14-3-3 Protein, beta Isoform; 14-3-3 Protein, epsilon Isoform; 14-3-3 Protein, eta Isoform; 14-3-3 Protein, gamma Isoform; 14-3-3 Protein, tau Isoform; 14-3-3 Protein, zeta Isoform; 14-3-3 beta Protein; 14-3-3 epsilon Protein; 14-3-3 eta Protein; 14-3-3 gamma Protein; 14-3-3 tau Protein; 14-3-3 zeta Protein; 14-3-3beta Protein; 14-3-3epsilon Protein; 14-3-3eta Protein; 14-3-3gamma Protein; 14-3-3tau Protein; 14-3-3zeta Protein; Brain 14-3-3 Protein; Protein 14-3-3; 14 3 3 Protein; 14 3 3 Protein, beta Isoform; 14 3 3 Protein, epsilon Isoform; 14 3 3 Protein, eta Isoform; 14 3 3 Protein, gamma Isoform; 14 3 3 Protein, tau Isoform; 14 3 3 Protein, zeta Isoform; 14 3 3 Proteins; 14 3 3 beta Protein; 14 3 3 epsilon Protein; 14 3 3 eta Protein; 14 3 3 gamma Protein; 14 3 3 tau Protein; 14 3 3 zeta Protein; 14 3 3beta Protein; 14 3 3epsilon Protein; 14 3 3eta Protein; 14 3 3gamma Protein; 14 3 3tau Protein; 14 3 3zeta Protein; 14-3-3 Protein, Brain; Brain 14 3 3 Protein; Protein, 14-3-3tau; eta Protein, 14-3-3

Networked: 250 relevant articles (3 outcomes, 26 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 60567
  - Carrier Proteins: 7962
    - Signal Transducing Adaptor Proteins
      - 14-3-3 Proteins: 250
        Arabidopsis 14-3-3 lambda protein
        Arabidopsis 14-3-3omega protein
        C elegans par-5 protein
        human YWHAB protein
        human YWHAE protein
        human YWHAH protein
        mouse Sfn protein
        mouse Wwtr1 protein
        rat 14-3-3 sigma protein
        S cerevisiae BMH1 protein
        S cerevisiae BMH2 protein
  - Intracellular Signaling Peptides and Proteins: 17
    - Signal Transducing Adaptor Proteins
      - 14-3-3 Proteins: 250
        Arabidopsis 14-3-3 lambda protein
        Arabidopsis 14-3-3omega protein
        C elegans par-5 protein
        human YWHAB protein
        human YWHAE protein
        human YWHAH protein
        mouse Sfn protein
        mouse Wwtr1 protein
        rat 14-3-3 sigma protein
        S cerevisiae BMH1 protein
        S cerevisiae BMH2 protein
- Peptides: 16716
  - Intracellular Signaling Peptides and Proteins: 17
    - Signal Transducing Adaptor Proteins
      - 14-3-3 Proteins: 250
        Arabidopsis 14-3-3 lambda protein
        Arabidopsis 14-3-3omega protein
        C elegans par-5 protein
        human YWHAB protein
        human YWHAE protein
        human YWHAH protein
        mouse Sfn protein
        mouse Wwtr1 protein
        rat 14-3-3 sigma protein
        S cerevisiae BMH1 protein
        S cerevisiae BMH2 protein

Experts

1.	Kawamoto, Yasuhiro: 6 articles (08/2005 - 03/2002)
2.	Akiguchi, Ichiro: 6 articles (08/2005 - 03/2002)
3.	Budka, Herbert: 6 articles (12/2004 - 03/2002)
4.	Yaffe, Michael B: 5 articles (09/2009 - 09/2004)
5.	Martinez, Jesse D: 5 articles (01/2008 - 08/2003)
6.	Umahara, Takahiko: 4 articles (06/2010 - 10/2004)
7.	Uchihara, Toshiki: 4 articles (06/2010 - 10/2004)
8.	Zhang, Xiang: 4 articles (02/2010 - 04/2006)
9.	Green, Alison: 4 articles (10/2009 - 05/2002)
10.	Watanabe, Kenichi: 4 articles (09/2009 - 06/2005)

Related Diseases

1.	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/01/1998 - "Diagnosis of Creutzfeldt-Jakob disease (CJD) at lifetime according to the international diagnostic criteria may be greatly improved by the additional assay of 14-3-3 protein in cerebrospinal fluid (CSF). " 07/28/2001 - "OBJECTIVE: To study whether an algorithm that includes additional diagnostic information could increase the specificity of the 14-3-3 protein testing in patients suspected to suffer from Creutzfeldt-Jakob disease (CJD). " 02/01/1999 - "This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases." 10/01/2010 - "After a positive finding of the 14-3-3 protein in her cerebrospinal fluid, she was diagnosed as having probable sporadic Creutzfeldt-Jakob disease." 11/01/2009 - "BACKGROUND: The 14-3-3 protein is a physiological cellular protein expressed in various tissues, and its release to CSF reflects extensive neuronal damage as in Creutzfeldt-Jakob disease (CJD), but also in other neurological diseases. " Order ALL the reference details at left...
2.	Bacterial Meningitis 06/01/2003 - "Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis." 03/01/2008 - "We tested the hypothesis that CSF 14-3-3 protein levels are substantially increased in acute bacterial meningitis and decreased after anti-microbial therapy, and that CSF 14-3-3 protein levels can predict treatment outcomes. " 03/01/2008 - "BACKGROUND: Increased levels of cerebrospinal fluid (CSF) 14-3-3 proteins have been reported in acute bacterial meningitis. " 03/01/2008 - "The value of serial cerebrospinal fluid 14-3-3 protein levels in adult community-acquired bacterial meningitis." 06/01/2003 - "We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. " Order ALL the reference details at left...
3.	Tropical Spastic Paraparesis (Tropical Spastic Paraplegia) 08/15/2003 - "The 14-3-3 protein was identified in seven CSF samples, including four patients with SPMS in acute relapse, one with SPMS in remission accompanied by fresh cerebral infarction, one with RRMS in acute relapse, and one with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy. " Order ALL the reference details at left...
4.	Cerebral Infarction 08/15/2003 - "The 14-3-3 protein was identified in seven CSF samples, including four patients with SPMS in acute relapse, one with SPMS in remission accompanied by fresh cerebral infarction, one with RRMS in acute relapse, and one with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy. " Order ALL the reference details at left...
5.	Parkinson Disease (Parkinson's Disease) 12/01/2002 - "14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta." 03/01/2002 - "To elucidate the role of 14-3-3 proteins in neuro-degenerative disorders associated with Lewy bodies, we performed immunohistochemical studies on 14-3-3 in brains from 5 elderly control subjects and from 10 patients with Parkinson disease (PD) or diffuse Lewy body disease (DLBD). " 03/01/2002 - "14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains." 01/01/2006 - "Studies on the localization of the 14-3-3 proteins in different types of inclusion bodies in the brain including neurofibrillary tangle in Alzheimer's disease, pick bodies in Pick's disease, Lewy body-like hyaline inclusions in sporadic amyotrophic lateral sclerosis, prion/florid plaques in sporadic/variant Creutzfeldt-Jakob disease, nuclear inclusions in spinocerebellar ataxia-1, and possibly Lewy bodies in Parkinson's disease suggest a close association of these diseases with 14-3-3 zeta. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	14-3-3 Proteins (14-3-3 Protein)
2.	Proteins (Proteins, Gene)
3.	Protein Isoforms (Isoforms)
4.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
5.	Calmodulin (Calcium-Dependent Activator Protein)
6.	Adenosine Triphosphate (ATP)
7.	MAP Kinase Kinase Kinase 5
8.	Brain-Derived Neurotrophic Factor (BDNF)
9.	Glutamic Acid (Glutamate)
10.	Annexin A5

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Denervation

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