14-3-3 σ: A potential biomolecule for cancer therapy.

Abstract

As more studies have focused on the function of 14-3-3 proteins, their role in tumor progression has gradually improved. In the 14-3-3 protein family, 14-3-3σ is the protein that is most associated with tumor occurrence and development. In some malignancies, 14-3-3σ acts as a tumor suppressor via p53 and tumor suppressor genes. In most tumors, 14-3-3σ overexpression increases resistance to chemotherapy and radiotherapy and mediates the G2-M checkpoint after DNA damage. Although 14-3-3σ overexpression has been closely associated with poorer prognosis in pancreatic, gastric and colorectal cancer, its role in gallbladder and nasopharyngeal cancer remains less clear. As such, the function of 14-3-3σ in specific cancer types needs to be further clarified. It has been hypothesized that a role may be related to its molecular chaperone function combined with various protein ligands. In this review, we examine the role of 14-3-3σ in tumor development and drug resistance. We discuss the potential of targeting 14-3-3σ regulators in cancer therapy and treatment.

• Authors: Yun Huang, Mingxiu Yang, Weiguo Huang
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 511 Pg. 50-58 (Dec 2020) ISSN: 1873-3492 [Electronic] Netherlands
• PMID: 32950519 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• 14-3-3 Proteins
• Biomarkers, Tumor
• Exonucleases

Topics

• 14-3-3 Proteins (genetics)
• Biomarkers, Tumor (genetics)
• Cell Line, Tumor
• DNA Damage
• Exonucleases (genetics, metabolism)
• Humans
• Nasopharyngeal Neoplasms