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Hypertelorism

Abnormal increase in the interorbital distance due to overdevelopment of the lesser wings of the sphenoid.
Also Known As:
Hypertelorisms
Networked: 295 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Infection
2. Craniofacial Dysostosis (Crouzon Disease)
3. Fissured Tongue
4. Down Syndrome (Down's Syndrome)
5. Cleft Lip (Harelip)

Experts

1. Wilkie, Andrew O M: 5 articles (04/2013 - 06/2004)
2. Hennekam, Raoul C M: 5 articles (02/2012 - 12/2004)
3. Verloes, Alain: 4 articles (05/2015 - 09/2005)
4. Chen, Chih-Ping: 4 articles (06/2013 - 06/2003)
5. Wang, Wayseen: 4 articles (06/2013 - 06/2003)
6. Twigg, Stephen R F: 4 articles (04/2013 - 06/2004)
7. Wall, Steven A: 4 articles (04/2013 - 06/2004)
8. Wieland, Ilse: 3 articles (02/2014 - 08/2005)
9. Chern, Schu-Rern: 3 articles (06/2013 - 06/2003)
10. Goriely, Anne: 3 articles (04/2013 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypertelorism:
1. Frontonasal dysplasiaIBA
2. Biological Markers (Surrogate Marker)IBA
3. AnotiaIBA
4. Penis agenesisIBA
5. Bifid noseIBA
6. Craniofrontonasal dysplasiaIBA
7. daminozide (Alar)IBA
8. Retinaldehyde (Retinal)IBA
03/01/2006 - "Hypertelorism/telecanthus, abnormally slanted palpebral fissures, abnormal retinal findings, nasolacrimal duct obstruction, anomalous extraocular muscles, amblyopia, and microcornea were found. "
03/01/1978 - "Multiple ophthalmic abnormalities were found, including hypertelorism, telecanthus, epicanthal folds, antimongoloid palpebral fissures, exotropia, optic atrophy, and tortuosity of the retinal vasculature. "
01/01/2001 - "The main abnormal physical features recorded at different ages consisted of hydrocephalus, axial hypotonia, absence of spontaneous prehension, long face, synophris, hypertelorism with epicanthic folds, internal alternating strabismus, retinal abnormalities with macular degeneration, beaked nose, long philtrum, high-arched palate, lumbar spina bifida, right paravertebral dimple at the upper sacral region, prominent coccyx, broad thumbs and great toes, fetal pads and cryptorchidism. "
08/06/1998 - "We report on two sisters who were born to a consanguineous couple and had retinitis pigmentosa-like pigmented retinal lesions, alternating exotropia, bilateral cataracts, and anomalous coarse facies characterized by deformed skull with narrow forehead, low anterior hairline, hypertelorism, short philtrum, thin upper lip, and prominent jaw; cerebellar vermis hypoplasia; dilatation of the fourth ventricle; severe mental retardation; tremor; brisk deep tendon reflexes and abnormal behavior; and skeletal abnormalities such as limited extension of elbow and/ or finger joints and talipes equinovalgus. "
9. Congenital Talipes EquinovarusIBA
01/01/1981 - "Clinical and cytogenetic examinations were performed on eight unrelated infants with duplication of part of the long arm of chromosome 3. A review of published cases shows a clinical syndrome characterized by statomotoric retardation, shortened life span, and a multiple congenital anomalies (MCA) syndrome of abnormal head configuration, hypertrichosis, hypertelorism, ocular anomalies, anteverted nostrils, long philtrum, maxillary prognathia, down-turned corners of the mouth, highly arched or cleft plate, micrognathia, malformed auricles, short, webbed neck, clinodactyly, simian crease, talipes, and congenital heart disease. "
08/01/1981 - "Major features include: (1) poorly mineralized calvarium, (2) dysmorphic facies (cleft lip and palate, micrognathia, upturned nares, apparent ocular hypertelorism), and (3) extracranial and musculoskeletal anomalies (absence of cervical vertebrae and clavicles, talipes equilnorvarus, and soft tissue syndactyly). "
06/01/2010 - "The patients exhibited strikingly similar features according to their age: craniofacial, large fontanelle, hypertelorism, short and downslanting palpebral fissures, blue sclerae, short nose with hypoplastic columella, low-set and rotated ears, high palate, long philtrum, thin vermilion of the upper lip, small mouth, and micro-retrognathia in infancy; slender and asymmetric face with protruding jaw from adolescence; skeletal, congenital contractures of fingers, wrists, and hips, and talipes equinovarus with anomalous insertions of flexor muscles; progressive joint laxity with recurrent dislocations; slender and/or cylindrical fingers and progressive talipes valgus and cavum or planus, with diaphyseal narrowing of phalanges, metacarpals, and metatarsals; pectus deformities; scoliosis or kyphoscoliosis with decreased physiological curvatures of thoracic spines and tall vertebrae; cutaneous, progressive hyperextensibility, bruisability, and fragility with atrophic scars; fine palmar creases in childhood to acrogeria-like prominent wrinkles in adulthood, recurrent subcutaneous infections with fistula formation; cardiovascular, cardiac valve abnormalities, recurrent large subcutaneous hematomas from childhood; gastrointestinal, constipation, diverticula perforation; respiratory, (hemo)pneumothorax; and ophthalmological, strabismus, glaucoma, refractive errors."
08/06/1998 - "We report on two sisters who were born to a consanguineous couple and had retinitis pigmentosa-like pigmented retinal lesions, alternating exotropia, bilateral cataracts, and anomalous coarse facies characterized by deformed skull with narrow forehead, low anterior hairline, hypertelorism, short philtrum, thin upper lip, and prominent jaw; cerebellar vermis hypoplasia; dilatation of the fourth ventricle; severe mental retardation; tremor; brisk deep tendon reflexes and abnormal behavior; and skeletal abnormalities such as limited extension of elbow and/ or finger joints and talipes equinovalgus. "
10. Greig cephalopolysyndactyly syndromeIBA

Therapies and Procedures

1. Osteotomy
2. Ventriculoperitoneal Shunt
3. Sutures (Suture)
4. Craniotomy
5. Transplants (Transplant)