Developmental Bone Diseases (Bone Dysplasia)

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61 relevant articles (0 outcomes, 5 trials/studies) found for this Disease

Also Known As:

Bone Dysplasia; Bone Diseases, Developmental; Developmental Bone Disease; Bone Disease, Developmental; Dysplasia, Bone; Dysplasias, Bone; Bone Dysplasias

Disease Context: Research Results

Musculoskeletal Diseases: 87

Bone Diseases: 2533

Developmental Bone Diseases: 61

Marfan Syndrome: 807

Dwarfism: 704

Osteochondrodysplasias: 387

Funnel Chest: 204

Gigantism: 141

Basal Cell Nevus Syndrome: 108

Dysostoses: 67

Leg Length Inequality: 43

Acro-Osteolysis: 37

Essential Osteolysis: 30

Platybasia: 18

Proteus Syndrome: 18

Related Diseases

1.	Osteolysis
2.	Bone Resorption
3.	beta-Thalassemia (Cooley's Anemia)
4.	Syndrome
5.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)

Experts

1.	Marle, N: 1 article (11/2007)
2.	Borgnon, J: 1 article (11/2007)
3.	Malka, G: 1 article (11/2007)
4.	Masurel-Paulet, A: 1 article (11/2007)
5.	Faivre, L: 1 article (11/2007)
6.	Le Merrer, M: 1 article (11/2007)
7.	Callier, P: 1 article (11/2007)
8.	Danino, A: 1 article (11/2007)
9.	Thauvin-Robinet, C: 1 article (11/2007)
10.	Mugneret, F: 1 article (11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Developmental Bone Diseases:

1.	Deferoxamine (Desferal)FDA LinkGeneric 08/01/2000 - "AIM: To study the radiographic findings of desferrioxamine-induced bone dysplasia, its prevalence and relation to growth in thalassaemic patients. " 07/01/2002 - "CONCLUSIONS: With provision of the modern regime of regular transfusion and desferrioxamine chelation, desferrioxamine-induced bone dysplasia was a much more frequently detected radiographic abnormality in beta-thalassaemia major than radiographic features owing to medullary expansion. " 07/01/2002 - "RESULTS: Sixteen patients had radiographic evidence of desferrioxamine-induced bone dysplasia. " 12/01/2000 - "CONCLUSION: Deferoxamine-induced bone dysplasia in the distal femur and patella is represented by a spectrum of morphologic changes in the epiphysis, physis, metaphysis, and metadiaphysis on MR imaging." 12/01/2000 - "Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance." Order ALL the reference details at left...
2.	CollagenIBA 02/01/1994 - "Recent advances show that some bone dysplasias result from defects in the biosynthesis of type II (cartilage) collagen. " 07/01/1980 - "It is suggested that these changes are in relationship to abnormal collagen metabolism and that CHF is not only a bone dysplasia but a more generalized condition with variable extraskeletal manifestations." 01/01/2001 - "Newly developed genetic analysis of bone dysplasia is an important subject, and this review focuses on collagen abnormalities, systemic disorders associated with neoplasms and receptor disorders. " 04/01/1998 - "Collagen gene mutations have been found to be responsible for osteogenesis imperfecta and many other bone dysplasias. " 01/01/1987 - "A survey study of growth cartilage abnormalities in bovine bone dysplasias revealed that a disorder in Holstein cattle called bulldog calf closely resembles human achondrogenesis Type II. Substantial amounts of Type I collagen and other non Type II collagens were detected in the bulldog cartilage which was comprised primarily of extensive vascular canals and cells having the characteristics of hypertrophic and degenerative chondrocytes normally found in the growth plate. " Order ALL the reference details at left...
3.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 07/01/1977 - "Calcitonin treatment in hereditary bone dysplasia with hyperphosphatasemia: a radiographic and histologic study of bone." 01/01/1979 - "It is concluded that familial bone dysplasia is primarily a disease of osteocytes and that osteocytic activity is influenced by calcitonin." 07/01/1977 - "Two children with bone dysplasia with hyperphosphatasemia (juvenile Paget's disease) were treated with synthetic human calcitonin. " 01/01/1976 - "Four cases of familial bone dysplasia with hyperphosphatasaemia were treated with synthetic human calcitonin. " 01/01/1976 - "Hereditary bone dysplasia with hyperphosphatasaemia: response to synthetic human calcitonin." Order ALL the reference details at left...
4.	Interleukin-6 (Interleukin 6)IBA 01/01/2006 - "It is now clear that normal skeletal stromal cells without mutation of the Gsalpha protein are necessary for the presence of bone dysplasia and that exaggerated production of interleukin-6 by fibrous bone cells with mutation of the Gsalpha protein is linked to the increased number of osteoclasts in bone tissues. " 07/01/1998 - "Our recent study has indicated that the cells derived from the fibrous bone dysplasia tissues in MAS patients produced increased levels of interleukin-6 (IL-6), which may be responsible for the increased bone resorption in this disease. " Order ALL the reference details at left...
5.	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 11/01/2001 - "Genetic factors are important in the pathogenesis of PDB, and previous studies have shown that the PDB-like bone dysplasia familial expansile osteolysis is caused by activating mutations in the TNFRSF11A gene that encodes receptor activator of nuclear factor kappa B (RANK); however, linkage studies, coupled with mutation screening, have excluded involvement of RANK in the vast majority of patients with PDB. " Order ALL the reference details at left...
6.	Collagen Type I (Type I Collagen)IBA 01/01/1987 - "A survey study of growth cartilage abnormalities in bovine bone dysplasias revealed that a disorder in Holstein cattle called bulldog calf closely resembles human achondrogenesis Type II. Substantial amounts of Type I collagen and other non Type II collagens were detected in the bulldog cartilage which was comprised primarily of extensive vascular canals and cells having the characteristics of hypertrophic and degenerative chondrocytes normally found in the growth plate. " Order ALL the reference details at left...
7.	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 11/01/1998 - "Hypochondroplasia is a bone dysplasia caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. " 03/22/1996 - "We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene to produce severe and progressive bone dysplasia with enhanced and prolonged endochondral bone growth. " Order ALL the reference details at left...
8.	Collagen Type II (Type II Collagen)IBA 09/01/2007 - "Significant ocular findings are a feature of heritable bone dysplasias resulting from defects in type II collagen." 04/01/1998 - "Bone dysplasias due to abnormalities in type II collagen." 09/01/2007 - "In bone dysplasias resulting from a defect of type II collagen there is likely to be a high risk of retinal detachment with a propensity to retinal tears at a young age." Order ALL the reference details at left...
9.	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 07/01/2000 - "FGF18 is thus likely an endogenous ligand of FGF receptor 3, whose mutation causes bone dysplasia in humans. " 05/01/1995 - "[Bone dysplasia, craniosynostoses, and fibroblast growth factor receptors]" Order ALL the reference details at left...
10.	Proteoglycans (Proteoglycan)IBA 03/01/1989 - "[Molecular heterogeneity of proteoglycan aggregates of human hyalin cartilage in normal conditions and in systemic bone dysplasia]" 04/01/1985 - "[Heterogeneity of binding proteins of proteoglycan aggregates from human hyaline cartilage under normal conditions and in systemic bone dysplasias]" Order ALL the reference details at left...

Therapies and Procedures

1.	Chelation Therapy (Therapy, Chelation) 08/01/2000 - "CONCLUSION: Desferrioxamine-induced bone dysplasia is associated with height reduction and can be seen in patients receiving desferrioxamine chelation therapy at doses of less than 50 mg/kg/day. " 07/01/2001 - "METHODS: The left knees of 32 patients with thalassemia who were receiving regular blood transfusions and chelation therapy were studied with sonography for signs of deferoxamine-induced bone dysplasia. " Order ALL the reference details at left...
2.	Cardiopulmonary Resuscitation (CPR) 04/01/2000 - "Data extracted from the individual patient charts included: age, sex, chief complaint, number and location of rib fractures, associated injuries, birth history, history of cardiopulmonary resuscitation, and any evidence of bone dysplasia. " Order ALL the reference details at left...
3.	Plasmapheresis 01/01/1992 - "Bone dysplasia associated with phytanic acid accumulation and deficient plasmalogen synthesis: a peroxisomal entity amenable to plasmapheresis." Order ALL the reference details at left...
4.	Osteotomy 03/01/1971 - "[Corrective osteotomies of lower extremities in fibrous bone dysplasia]" Order ALL the reference details at left...
5.	Dilatation and Curettage (D&C) 11/01/1978 - "The present paper describes a case of spondyloepiphyseal dysplasia congenita (S.D.C.), a heritable bone dysplasia manifested at birth and characterized by short stature and retarded ossification of vertebral bodies, pelvis and extremities. " Order ALL the reference details at left...

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