Hemoglobinuria

The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.

Networked: 319 relevant articles (12 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemolysis
2.	Hemolytic Anemia
3.	Acidosis
4.	Anemia
5.	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)

Experts

1.	Hillmen, Peter: 3 articles (09/2022 - 02/2004)
2.	Takagi, Mitsuhiro: 3 articles (12/2016 - 08/2009)
3.	Yamato, Osamu: 3 articles (12/2016 - 08/2009)
4.	Rother, Russell P: 3 articles (05/2009 - 02/2004)
5.	Chen, Tao: 2 articles (08/2022 - 01/2021)
6.	Ge, Chun-Xiao: 2 articles (08/2022 - 01/2021)
7.	Li, Ke-Lei: 2 articles (08/2022 - 01/2021)
8.	Qin, Zhong-Ping: 2 articles (08/2022 - 01/2021)
9.	Tai, Mao-Zhong: 2 articles (08/2022 - 01/2021)
10.	Xu, Zhen-Guo: 2 articles (08/2022 - 01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemoglobinuria:

1.	HaptoglobinsIBA 01/01/1980 - "From the above it may be concluded that the administration of haptoglobin is effective for the prevention of hemoglobinuria and subsequent renal damage." 01/01/1994 - "Hemoglobinuria reappeared 2 hours after haptoglobin was first administered. " 10/01/1990 - "Though prominent hemoglobinemia was observed in both cases, the serum haptoglobin values were not saturated and hemoglobinuria was not detectable. " 04/01/1985 - "The time required for macroscopic hemoglobinuria to clear showed a statistically significant difference between the haptoglobin-treated patients and the control patients. " 01/01/1980 - "This report describes the role of haptoglobin in preventing hemoglobinuria. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 02/01/2011 - "Based on the above analyses and observation of typical clinical symptoms, a speculative diagnosis of bacillary hemoglobinuria was made, and immediate high-dose antibiotic treatment improved the general conditions of the surviving animals. " 08/01/2009 - "Although the first 2 patients died, the hemoglobinuria and general condition of the remaining 2 cows, who were immediately initiated on large doses of antibiotics, improved within 3 days. " 12/01/2016 - "Recovery with a regular dose of antibiotics from bacillary hemoglobinuria in a Holstein cow."
3.	Hemoglobins (Hemoglobin)IBA 02/01/1986 - "Clinical studies on canine dirofilarial hemoglobinuria: relationship between the presence of heartworm mass at the tricuspid valve orifice and plasma hemoglobin concentration." 03/01/2009 - "Elevated levels of circulating plasma free hemoglobin (FHb) has been linked to the development of hemoglobinuria nephropathy. " 01/01/2007 - "Accordingly, we now describe in detail the mechanisms by which hemoglobinuria may induce renal injury and raise the question as to whether CPB-associated AKI may actually be, in a significant part, a form of pigment nephropathy where hemoglobin is the pigment responsible for renal injury. " 03/01/2005 - "Evanescent wave cavity ring-down spectroscopy (EW-CRDS) is used to observe the adsorption isotherm for hemoglobin (Hb) from controlled urine samples to assess the potential for rapid diagnosis in hemoglobinuria. " 08/01/1997 - "However, unmodified bovine hemoglobin did demonstrate significant hemoglobinuria (Hb excretion levels in excess of 1.0% of the infused dose [p < 0.05]) at all infusion rates given while PEG modified bovine hemoglobin did not. "
4.	Complement System Proteins (Complement)IBA 06/01/1996 - "These findings suggest that PNH remains stable when the number of complement-sensitive erythrocytes remains fairly constant, and that the PNH III erythrocyte count is especially related to the frequency of hemoglobinuria. " 06/01/1993 - "Paroxystic nocturnal hemoglobinuria (PNH) is an acquired hemolytic anaemia related to an increase susceptibility of erythrocytes to complement-mediated lysis. " 09/01/1984 - "Complement sensitivity of erythroid and myeloid precursors in paroxysmal in nocturnal hemoglobinuria." 02/05/2004 - "This antibody against terminal complement protein C5 reduces intravascular hemolysis, hemoglobinuria, and the need for transfusion, with an associated improvement in the quality of life in patients with PNH." 01/01/2018 - "In this study, we found that administration of SSL7 significantly prevented complement-mediated hemolysis and reduced hemoglobinuria in a mouse model of complement-mediated intravascular hemolysis. "
5.	Glutathione (Reduced Glutathione)IBA 10/01/1999 - "The increased rate of removal of blood radioactivity was accompanied by a rapid decline in reduced glutathione levels in the blood, decreased hematocrits, marked hemoglobinuria, splenic enlargement, and reticulocytosis. " 04/01/2012 - "Significantly decreased level of nitrites and increased value of glutathione was found in patients with hemoglobinuria and jaundice, respectively. " 11/01/2017 - "BJ rats showed markedly reduced glomerular filtration rate (GFR, inulin clearance) associated with intense renal vasoconstriction, hemolysis, hemoglobinuria, reduced glutathione and increased systemic and renal markers of nitro-oxidative stress (Nitrotyrosine). " 08/01/1987 - "During the time cows 6 and 7 had hemoglobinuria, both cows had a marked decrease in serum inorganic phosphorus, RBC adenosine 5'-triphosphate (ATP), and reduced glutathione, and a significant (P less than 0.01) increase in methemoglobin concentration. "
6.	SolutionsIBA 02/01/1980 - "Atypically light red cells were detected at the plasma--phycoll solution (with a specific gravity of 1.077) boundary in 24 out of 26 patients with paroxysmal nocturmal hemoglobinuria (PNH) by means of centrifugation of the patients' blood in 600 g density gradient for 30 minutes. " 01/01/1990 - "The asanguinous hyperosmolar priming solution is beneficial for cardiopulmonary bypass in swine to greatly reduce fluid shifts, prevent metabolic acidosis, and eliminate hemoglobinuria." 12/01/2004 - "The ingestion of copper solution caused an intense gastrointestinal injury that resulted in ulcers, petechial and echymotic hemorrhages in the mucosa, mild hemolysis detected by microscopic hemoglobinuria and a lowered packed cell volume, severe hepatic injury that raised the AST and gammaGT blood values, and moderate kidney lesions with increasing serum blood urea and nitrogen creatinine levels."
7.	Adenosine Triphosphate (ATP)IBA 02/01/1974 - "Letter: Adenosine triphosphate in paroxysmal noctural hemoglobinuria red blood cell." 04/01/1992 - "2. Dogs having HK RBCs (HK dogs) revealed no clinical and hematological changes after administration of L-sorbose, whereas normal dogs (LK dogs) developed severe hemolytic anemia associated with hemoglobinuria and marked decreases of erythrocyte ATP concentrations. " 08/01/1987 - "During the time cows 6 and 7 had hemoglobinuria, PCV, hemoglobin concentration, and RBC count decreased progressively and reached nadir values, 40% to 50% of baseline values, on day 22 in cow 6 and on day 19 in cow 7. Cows 6 and 7 were anemic, even after serum inorganic phosphorus and RBC ATP values returned to acceptable values. " 08/01/1987 - "During the time cows 6 and 7 had hemoglobinuria, both cows had a marked decrease in serum inorganic phosphorus, RBC adenosine 5'-triphosphate (ATP), and reduced glutathione, and a significant (P less than 0.01) increase in methemoglobin concentration. "
8.	Danazol (Azol)FDA LinkGeneric 01/01/1990 - "Case report of a 39-year-old woman treated by Danazol for a paroxystic nocturnal hemoglobinuria who developed benign intracranial hypertension and sclerosing cholangitis. " 09/01/1990 - "When treated with danazol by mouth, the hemoglobin level increased approximately 2 to 5 grams in each patient within 3 week, and clinical hemoglobinuria improved. "
9.	Adenosine (Adenocard)FDA LinkGeneric 12/01/1996 - "Dimethylsulfone, an analog of DMSO that does not affect RBCs, did not cause hemoglobinuria and did not affect urinary adenosine. " 12/01/1996 - "Boluses and infusions of DMSO caused a reduction in urinary adenosine and a concomitant hemoglobinuria, and the ability of DMSO to reduce urinary adenosine was blocked by pretreatment with the ADA inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine. " 08/01/1987 - "During the time cows 6 and 7 had hemoglobinuria, both cows had a marked decrease in serum inorganic phosphorus, RBC adenosine 5'-triphosphate (ATP), and reduced glutathione, and a significant (P less than 0.01) increase in methemoglobin concentration. "
10.	SilkFDA Link 07/01/1968 - "Efficacy of maize silk in acute hemolytic anemia accompanied with hemoglobinuria. "

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 01/01/2016 - "The brain-dead donor had received a massive blood transfusion during cardiopulmonary bypass, which lead to hemolysis, hemoglobinuria, acute kidney injury, and renal replacement therapy. " 02/01/2006 - "However, they had significantly lower mean hemoglobin levels during cardiopulmonary bypass compared to those sickle cell patients who did not exhibit hemoglobinuria (hemoglobin, 6.0 +/- 0.2 vs. 7.4 +/- 0.9 g x dL(-1), p < 0.01). " 01/01/1990 - "The asanguinous hyperosmolar priming solution is beneficial for cardiopulmonary bypass in swine to greatly reduce fluid shifts, prevent metabolic acidosis, and eliminate hemoglobinuria."
2.	Surgical Instruments (Clip) 06/01/1988 - "Efficacy of heartworm removal in dogs with dirofilarial hemoglobinuria using flexible alligator forceps."
3.	Therapeutics 04/01/2003 - "We recently encountered two cases of black urine (hemoglobinuria) in patients treated with combination therapy. " 12/01/1954 - "[Therapy of idiopathic hemoglobinuria]." 06/19/1948 - "[Contribution to the study of therapy of bilious fever hemoglobinuria]." 09/01/1955 - "[Acute hemolytic reaction (hemoglobinuria fever) in therapy with streptocide]." 01/01/1952 - "[Marchiafava-Micheli's hemolytic anemia with hemoglobinuria and hemosidenuria; general considerations and therapy]."
4.	Sclerotherapy 09/01/2012 - "The purpose of this article is to study the incidence, risk factors, and treatment of gross hemoglobinuria and oliguria following sclerotherapy for venous malformations. " 09/01/2012 - "Transient hemoglobinuria and oliguria are common complications of sclerotherapy for venous malformation. " 09/01/2012 - "Gross hemoglobinuria and oliguria are common transient complications of sclerotherapy for venous malformations: review of 475 procedures." 03/01/2013 - "Complications of sclerotherapy include tissue necrosis, peripheral nerve injury, hemoglobinuria, deep vein thrombosis, and pulmonary embolism. " 09/01/2012 - "The risk of hemoglobinuria increased with higher adjusted dose (sclerosant volume/weight of patient) for both agents and with sclerotherapy of venous malformations affecting the lower extremities and multiple locations. "
5.	Intravenous Injections 01/01/1934 - "3. Their intravenous injection into mice causes marked hemoglobinuria, anemia, and death. " 03/01/1941 - "STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS." 09/26/1983 - "Intravenous injection of DMSO produced neuro-muscular disturbances, hemolysis, and hemoglobinuria in all animals. " 10/01/1965 - "Hypotension and hemoglobinuria in rats following intravenous injections of hypertonic solutions."