[Treatment of paroxysmal nocturnal hemoglobinuria with danazol].

Abstract

Glucocorticoid and androgen therapy have been used with moderate success in paroxysmal nocturnal hemoglobinuria (PNH). However, both are poorly tolerated, especially in women, although the side effects of glucocorticoid can be diminished by alternate day therapy. We have treated two patients with PNH with danazol. One of patient is man, 64 years old age with stomach cancer, and the other patient is 34-year-old man. Their disease has existed for 6-14 years. They required many blood transfusions, their hemoglobins ranging between 7.1 and 9.9 grams per deciliter. When treated with danazol by mouth, the hemoglobin level increased approximately 2 to 5 grams in each patient within 3 week, and clinical hemoglobinuria improved. None of the patients has had any side effects.

• Authors: Y Yoshimura, A Nakayama, H Hama, J Oguchi, J Matsuda, M Kamakura, T Kinoshita, M Yamanaka, T Abe
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 31 Issue 9 Pg. 1489-92 (Sep 1990) ISSN: 0485-1439 [Print] Japan
• PMID: 2246821 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Hemoglobins
• Danazol

Topics

• Adult
• Danazol (therapeutic use)
• Hemoglobins (metabolism)
• Hemoglobinuria, Paroxysmal (blood, drug therapy)
• Humans
• Male
• Middle Aged