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Globins

A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.
Also Known As:
Globin
Networked: 2716 relevant articles (68 outcomes, 256 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Fucharoen, Suthat: 40 articles (01/2021 - 12/2002)
2. Svasti, Saovaros: 29 articles (01/2022 - 11/2008)
3. Rivella, Stefano: 28 articles (11/2019 - 10/2002)
4. Gambari, Roberto: 26 articles (01/2022 - 01/2008)
5. Chui, David H K: 22 articles (01/2022 - 03/2002)
6. Fucharoen, Supan: 21 articles (08/2021 - 01/2002)
7. Li, Dong-Zhi: 20 articles (07/2022 - 01/2011)
8. Nakamura, Yukio: 20 articles (03/2022 - 01/2016)
9. Steinberg, Martin H: 20 articles (01/2022 - 02/2003)
10. Fucharoen, Goonnapa: 19 articles (08/2021 - 01/2002)

Related Diseases

1. Thalassemia
04/15/2011 - "The enormous progress in the technique for β-globin gene analysis permitted to characterize 99.93% of mutated alleles and it has made a first trimester prenatal diagnosis program possible in our region in all cases with a great improvement in thalassemia management. "
01/01/2018 - "After previously establishing that lentiviral transfer of a marked β-globin (βA-T87Q) gene could substitute for long-term red-cell transfusions in a patient with β-thalassemia, we wanted to evaluate the safety and efficacy of such gene therapy in patients with transfusion-dependent β-thalassemia. "
11/01/2014 - "Overall survival was not found to be associated with the β-globin gene mutation status, but thalassemia-free survival was significantly improved in patients with homozygous mutations compared with patients with compound heterozygous mutations in univariate (91.2% versus 64.0%, P = .009) and multivariable (hazard ratio, 3.83; P = .014) analyses. "
10/01/2020 - "It took more than 40 years for scientists and physicians to advance from the cloning of globin gene and discovering globin gene mutations to improving our understanding of the pathophysiological mechanisms involved, the detection of genetic modifiers, the development of animal models and gene transfer vectors, comprehensive animal testing, and demonstrations of phenotypic improvement in clinical trials, culminating in the authorization of the first gene therapy product for β-thalassemia in 2019. "
03/06/2014 - "Thus, we validated a safe and effective procedure for β-globin gene transfer in thalassemia patient CD34(+) HPCs, which we will implement in the first US trial in patients with severe inherited globin disorders. "
2. Sickle Cell Anemia (Hemoglobin S Disease)
3. Hemoglobinopathies
4. beta-Thalassemia (Cooley's Anemia)
01/01/2022 - "Erythrocytes differentiated from SCD HSCs transduced with the DS demonstrated significantly reduced in vitro sickling phenotype compared to the SS. Erythrocytes differentiated from transduced HSCs from β-thalassemia major patients demonstrated improved globin chain balance by increased γ-globin with reduced microcytosis. "
01/01/2011 - "In order to evaluate the efficacy of a non-invasive prenatal diagnosis (NIPD) test to exclude α-thalassemia major that uses SNPs linked to the normal paternal α-globin allele, we established a novel protocol to reliably detect paternal SNPs within the (--(SEA)) breakpoints and performed evaluation of the diagnostic potential of the protocol in a total of 67 pregnancies, in whom plasma samples were collected prior to invasive obstetrics procedures in southern China. "
09/21/2018 - "In addition, BCL11A enhancer modification in mobilized CD34+ cells from patients with β-thalassemia major resulted in a readily detectable γ-globin increase with a preferential increase in G-gamma, leading to an improved phenotype and, likely, a survival advantage for maturing erythroid cells after editing. "
01/01/2022 - "Genetic Background Studies of Eight Common Beta Thalassemia Mutations in Thailand Using β-Globin Gene Haplotype and Phylogenetic Analysis."
04/01/2019 - "Materials and Methods: In this study, we investigated three frequent mutations (c.315+1G>A, c.93-21G>A and c.92+5G>C in β-globin gene, the frequency of RFLP haplotypes, and LD between markers at β-globin gene cluster) in 150 beta-thalassemia patients and 50 healthy individuals. "
5. Anemia

Related Drugs and Biologics

1. Fetal Hemoglobin (Hemoglobin F)
2. Hemoglobins (Hemoglobin)
3. Globins
4. gamma-Globins
5. Phosphotransferases (Kinase)
6. Messenger RNA (mRNA)
7. DNA (Deoxyribonucleic Acid)
8. alpha-Globins
9. Proteins (Proteins, Gene)
10. beta-Globins (beta Globin)

Related Therapies and Procedures

1. Therapeutics
2. Blood Transfusion (Blood Transfusions)
3. Cell- and Tissue-Based Therapy (Cell Therapy)
4. Transplantation
5. Chelation Therapy (Therapy, Chelation)