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Alkylating Agents

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Also Known As:
Alkylators; Agents, Alkylating
Networked: 1837 relevant articles (97 outcomes, 160 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kaina, Bernd: 10 articles (11/2015 - 04/2003)
2. Denny, William A: 9 articles (03/2012 - 03/2002)
3. Margison, Geoffrey P: 8 articles (05/2015 - 11/2002)
4. Stovall, Marilyn: 8 articles (09/2013 - 02/2002)
5. Weller, Michael: 7 articles (04/2014 - 03/2005)
6. Oberlin, Odile: 6 articles (11/2015 - 03/2003)
7. Wick, Wolfgang: 6 articles (01/2014 - 05/2008)
8. Bobola, Michael S: 6 articles (08/2012 - 09/2002)
9. Blank, A: 6 articles (08/2012 - 09/2002)
10. Silber, John R: 6 articles (08/2012 - 09/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Multiple Myeloma
3. Breast Neoplasms (Breast Cancer)
4. Glioblastoma (Glioblastoma Multiforme)
5. B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

Related Drugs and Biologics

1. Cyclophosphamide (Cytoxan)
2. DNA (Deoxyribonucleic Acid)
3. temozolomide (Temodar)
4. Vincristine (Oncovin)
5. Doxorubicin (Adriamycin)
6. Ifosfamide
7. Carmustine (FIVB)
8. Anthracyclines
9. Chlorambucil (Leukeran)
10. Adrenal Cortex Hormones (Corticosteroids)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Combination Drug Therapy (Combination Chemotherapy)
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Stem Cell Transplantation