Synthetic Cathinone

A propiophenone derivative chemically related to cathinone, a substance found in the KHAT plant.

Also Known As:

((R,S)-MDPV)); Bath Salts, Psychoactive; Cathinones, Synthetic; Salts, Psychoactive Bath; (3,4)-Methylenedioxypyrovalerone; 3,4-Methylenedioxypyrovalerone; MDPV; MDPV Compound; Methylenedioxypyrovalerone; Psychoactive Bath Salts; Synthetic Cathinones

Networked: 157 relevant articles (3 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Propiophenones: 1
    - Synthetic Cathinone: 157

Experts

1.	Penders, Thomas M: 6 articles (01/2017 - 09/2011)
2.	Carvalho, Félix: 4 articles (03/2021 - 08/2016)
3.	Sprague, Jon E: 4 articles (01/2019 - 05/2014)
4.	Rice, Kenner C: 3 articles (11/2021 - 11/2014)
5.	Rawls, Scott M: 3 articles (03/2021 - 03/2019)
6.	Bastos, Maria de Lourdes: 3 articles (01/2020 - 08/2016)
7.	Carvalho, Márcia: 3 articles (01/2020 - 08/2016)
8.	Guedes de Pinho, Paula: 3 articles (01/2020 - 08/2016)
9.	Febo, Marcelo: 3 articles (11/2019 - 01/2016)
10.	Huang, Yu: 3 articles (12/2018 - 01/2016)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 01/01/2013 - "In this study we summarize 5 short case studies that demonstrate the heterogeneous symptoms associated with MDPV abuse, and draw attention to the frequently occurring delusions, and the extended risk of intravenous substance use. " 08/01/2021 - "This article focuses on several common synthetic cathinones, collects their research results in animal autonomous activity experiments and drug dependence model experiments and summarizes their relevant experimental conclusions in animal body temperature regulation, learning and memory, and anxiety, in order to provide data reference and method guidance for the domestic development of related drug research. " 01/01/2019 - "The second largest group of new drugs monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) is synthetic cathinones. " 11/01/2021 - "Understanding the behavioral and/or pharmacological factors that can prevent the development of dysregulated MDPV self-administration may provide insight into individual differences in vulnerability to develop a substance use disorder." 01/01/2020 - "This study aims to assess whether clients of opioid substitution treatment (OST) with and without a history of synthetic cathinone use during therapy differ in (1) the rate and type of experienced childhood trauma, (2) the way they cope with negative life events, (3) their motivation to change substance use behavior, (4) the rate of treatment retention. "
2.	Poisoning 01/24/2023 - "Toxicological Analysis of Cases of Mixed Poisonings with Synthetic Cathinones and Other Drugs of Abuse." 02/01/2017 - "Poisoning to α-pyrrolidinovalerophenone (α-PVP), a synthetic cathinone." 06/01/2015 - "3-Methyl-methcathinone (3-MMC) is a novel, synthetic cathinone analog, recently linked to poisoning events among recreational users. " 03/01/2019 - "Synthetic cathinone use emerged in the United States by 2009 with use associated with tens of thousands of poisonings. " 02/01/2018 - "Co-consumed benzodiazepines seem not be able to completely prevent psychotic effects despite their use as first-line treatment for patients with synthetic cathinone poisonings. "
3.	Drug-Related Side Effects and Adverse Reactions 01/01/2020 - "Clinicians should be aware of possible interactions between synthetic cathinones and prescription drugs, which may increase the risk of drug toxicity or reduce the therapeutic efficacy of the drugs. "
4.	Hyperthermia 08/01/2016 - "Therefore, the present in vitro study aimed to provide insights into cellular mechanisms involved in MDPV-induced hepatotoxicity and also evaluate the contribution of hyperthermia to the observed toxic effects. " 11/01/2015 - "In MDPV intoxications with serum levels >100 ng/mL, the cases were graded as more severe and hyperthermia was less common. " 11/01/2014 - "MDPV also produced hyperthermia that was independent of strain and unrelated to the conditioned taste avoidance. " 07/01/2012 - "It is unknown whether these end-organ effects were due to direct cellular toxicity induced by MDPV or a result of the patient's marked agitation and hyperthermia. " 03/25/2023 - "Specifically, synthetic cathinones appear to be involved in different neurological events, including increased alertness, mild agitation, severe psychosis, hyperthermia and death. "
5.	Neuroinflammatory Diseases 03/01/2019 - "However, additional studies on synthetic cathinone-induced neuroinflammation are clearly needed, as are investigations into the neurochemical and neuroimmune mechanisms underlying their neurotoxic effects. " 01/01/2022 - "These results suggest that synthetic cathinone use likely produces sex-selective patterns of neuroinflammation during the transition from use to abuse. " 03/01/2019 - "Cognitive deficits and neurotoxicity induced by synthetic cathinones: is there a role for neuroinflammation?" 11/01/2022 - "It has been shown that synthetic cathinones have abuse potentials similar to psychomotor stimulants such as amphetamine and induce neuroinflammation. " 01/01/2023 - "The article presents current views on the mechanisms of neurotoxicity of synthetic cathinones, including: blood-brain barrier damage, mitochondrial dysfunction, oxidative stress, neuroinflammation and hyperthermia. "

Related Drugs and Biologics

1.	Benzodiazepines
2.	Vaccines
3.	Prescription Drugs
4.	Conjugate Vaccines
5.	Synthetic Cathinone
6.	Cannabinoids
7.	mephedrone
8.	Methylphenidate (Ritalin)
9.	Ketamine
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Therapeutics
2.	Opiate Substitution Treatment
3.	Self Administration (Administration, Self)
4.	Subcutaneous Injections
5.	Transcutaneous Electric Nerve Stimulation (TENS)