alpha 1 Chain Collagen Type I

A fibrillar collagen found predominantly in BONE and SKIN.

Also Known As:

Collagen Type I, alpha 1 Chain; Protein, COL1A1; COL1A1 Protein; Collagen Type I, alpha 1 Subunit; Collagen alpha 1 (I); Pro alpha 1 Collagen; Pro-alpha1(I) Collagen; Procollagen alpha1(I); Type I Collagen alpha 1

Networked: 89 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Collagen: 52417
      - Fibrillar Collagens: 517
        Collagen Type I: 5821
        alpha 1 Chain Collagen Type I: 89
        human COL1A1 protein
        mouse Col1a1 protein
        rat Col1a1 protein

Experts

1.	Schuppan, Detlef: 3 articles (01/2018 - 07/2005)
2.	Jia, J D: 3 articles (09/2001 - 06/2000)
3.	Riecken, E O: 3 articles (09/2001 - 06/2000)
4.	Ruehl, M: 3 articles (09/2001 - 06/2000)
5.	Schuppan, D: 3 articles (09/2001 - 06/2000)
6.	Chen, Ming: 2 articles (05/2020 - 01/2017)
7.	Chen, Anping: 2 articles (01/2020 - 01/2018)
8.	Ding, Hai: 2 articles (01/2020 - 01/2018)
9.	Shao, Jiangjuan: 2 articles (01/2020 - 01/2018)
10.	Zhang, Feng: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Fibrosis (Cirrhosis) 05/13/2021 - "The representative compound 29 attenuated collagen type I alpha 1 chain (COL1A1) expression in a mouse fibrosis model, which suggests that selective inhibition of TGF-βRII-dependent signaling could be a new treatment for fibrotic disorders." 01/01/2018 - "Procollagen alpha1(I) knockdown also downregulated procollagens type III, IV and VI and other fibrosis related parameters. " 05/01/1994 - "These experiments suggest that hepatocyte lipid peroxidation plays a major role in the regulation of collagen alpha 1(I) gene expression by Ito cells and that it may be a link between hepatocyte injury and hepatic fibrosis." 05/01/1994 - "Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis?" 09/01/2001 - "Contrary to procollagen alpha1(I) and TIMP-1, C18 expression remains constant in acute fibrogenesis and is upregulated in biliary fibrosis. "
2.	Hypophosphatemia 12/01/2002 - "When transgene Phex expression, driven by a mouse pro-alpha1(I) collagen gene promoter, was crossed into the Hyp background, it improved the defective mineralization of bone and teeth but failed to correct the hypophosphatemia and altered vitamin D metabolism associated with the disorder. "
3.	Osteosarcoma (Osteogenic Sarcoma) 09/01/2000 - "Exposure of osteoblast-like osteosarcoma cells or bone marrow-derived primary osteoblasts to either metallic or polymeric particles of phagocytosable sizes resulted in a marked decrease in the steady-state messenger RNA (mRNA) levels of procollagen alpha1[I] and procollagen alpha1[III]. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/2019 - "In this study, we aimed to investigate whether vitamin D receptor (VDR) Fok1 and collagen protein Col1A1 Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors. "
5.	Thyroid Neoplasms (Thyroid Cancer) 08/01/2000 - "In one out of five tissue samples from human undifferentiated thyroid carcinomas, pro-alpha1(I) collagen mRNA expression was also found in a small number of tumour cells. " 08/01/2000 - "Several well-characterized cell lines established from undifferentiated thyroid carcinomas, two from tumours included in the present study, expressed both pro-alpha1(I) collagen and prolyl 4-hydroxylase mRNA, and three of these cell lines also synthesized native triple-helical collagen type I. Taken together, these data suggest that stromal fibroblasts are the main producers of collagen type I in anaplastic thyroid tumours. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Procollagen
3.	Vitamin D
4.	Collagen Type I (Type I Collagen)
5.	Collagen
6.	Hydroxyproline (4 Hydroxyproline)
7.	Prolyl Hydroxylases (Prolyl Hydroxylase)
8.	Calcitriol Receptors (Calcitriol Receptor)
9.	Minerals
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Ligation
2.	Lasers (Laser)
3.	Injections
4.	Electric Stimulation Therapy (Electrotherapy)
5.	Aftercare (After-Treatment)