Thiamethoxam

A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.

Also Known As:

3-(2-Chloro-thiazol-5-ylmethyl)-5-methyl-(1,3,5)oxadiazinan-4-yldene-N-nitroamine; ACTARA 25 WG; Actara; CGA 293343; CGA-293343; CGA293343; 4H-1,3,5-Oxadiazin-4-imine, 3-((2-chloro-5-thiazolyl)methyl)tetrahydro-5-methyl-N-nitro-

Networked: 49 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Green, Trevor: 3 articles (07/2005 - 07/2005)
2.	Zhang, Zhixiang: 2 articles (05/2020 - 05/2019)
3.	Sanderson, J Thomas: 2 articles (10/2017 - 01/2016)
4.	Lee, Robert: 2 articles (07/2005 - 07/2005)
5.	Noakes, James: 2 articles (07/2005 - 07/2005)
6.	Peffer, Richard: 2 articles (07/2005 - 07/2005)
7.	Toghill, Alison: 2 articles (07/2005 - 07/2005)
8.	Waechter, Felix: 2 articles (07/2005 - 07/2005)
9.	Weber, Edgar: 2 articles (07/2005 - 07/2005)
10.	Copeland, Rick: 1 article (05/2022)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2005 - "Comparisons of the metabolism of thiamethoxam in rats and mice have shown that concentrations of the parent chemical were either similar or higher in rat blood than in mouse blood in both single dose and the dietary studies strongly indicating that thiamethoxam itself is unlikely to play a role in the development of liver tumors. " 07/01/2005 - "Thiamethoxam induced mouse liver tumors and their relevance to humans. " 07/01/2005 - "Thiamethoxam induced mouse liver tumors and their relevance to humans. " 07/01/2005 - "Indeed, rats fed 3000 ppm thiamethoxam for a lifetime did not develop hepatotoxicity or tumors. " 07/01/2005 - "This combination of metabolite-generated hepatotoxicity and increase in cell replication rates is postulated as the mode of action for thiamethoxam-related mouse liver tumors. "
2.	Liver Neoplasms (Liver Cancer) 07/01/2005 - "Thiamethoxam is a neonicotinoid insecticide that is not a mutagen, but it did cause a significant increase in liver cancer in mice, but not rats, in chronic dietary feeding studies. " 01/01/2022 - "In the present study, we detected six parent NEOs (p-NEOs), including acetamiprid, thiacloprid, dinotefuran, clothianidin, imidacloprid, and thiamethoxam, and five characteristic metabolites (m-NEOs), including 5-hydroxy-imidacloprid, olefin-imidacloprid, N-desmethyl-acetamiprid, 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1-methyl-3-(tetrahydro-3-furyl methyl) urea, in blood samples collected from healthy donors (n = 100; females vs. males: 45 vs. 55; age: 22-91 years) and liver cancer patients (n = 274; females vs. males: 118 vs. 156; age: 11-88 years) in one hospital from Guangzhou city, South China. "
3.	Neuroblastoma 07/01/2023 - "Due to the lack of information on their mechanism of toxicity, the effects of imidacloprid and thiamethoxam on DNA methylation as the most used marker for epigenetic effects were investigated in human neuroblastoma (SH-SY5Y) cells. " 11/01/2020 - "In this study, the combined toxicity of imidacloprid (IM), acetamiprid (AC) and thiamethoxam (TH) was investigated using human neuroblastoma cell line (SK-N-SH) and lepidopteran cell line (Sf-9). " 06/01/2018 - "We aimed to investigate possible effects of common neonicotinoid insecticides (acetamiprid, clothianidin, imidacloprid, thiacloprid, and thiamethoxam) on cytotoxicity and DNA damage in human neuroblastoma (SH-SY5Y) and human hepatocellular carcinoma (HepG2) cells. "
4.	Paralysis (Palsy) 01/01/2019 - "Influence of chronic exposure to thiamethoxam and chronic bee paralysis virus on winter honey bees." 01/01/2019 - "Therefore, the present study describes the influence of chronic co-exposure to thiamethoxam and Chronic bee paralysis virus (CBPV) on bee survival, virus loads, expression level of immune and detoxication genes, and pesticide metabolism Experiments were performed on honey bees collected from a winter apiary with reduced viral contaminations. " 01/01/2018 - "Using a similar chronic exposure to pesticide, we then studied, in a separate experiment, the impact of thiamethoxam and Chronic bee paralysis virus (CBPV) co-exposure in honeybees. " 01/01/2018 - "Metabolisation of thiamethoxam (a neonicotinoid pesticide) and interaction with the Chronic bee paralysis virus in honeybees."
5.	Dehydration (Water Stress) 08/01/2009 - "A sublethal dose of thiamethoxam causes a reduction in xylem feeding by the bird cherry-oat aphid (Rhopalosiphum padi), which is associated with dehydration and reduced performance." 01/01/2018 - "We found that water-stress and clothianidin consistently increased BGM densities, while thiamethoxam-treated plants only had this effect when plants were mature. " 01/01/2018 - "We conducted a field study to examine the effects of water-stress (optimal irrigation = 100% estimated evapotranspiration (ET) replacement, water stress = 25% of the water provided to optimally irrigated plants) and neonicotinoid seed treatments (control, clothianidin, thiamethoxam) on resident mite populations in corn (Zea mays, hybrid KSC7112). "

Related Drugs and Biologics

1.	imidacloprid
2.	Neonicotinoids
3.	clothianidin
4.	Insecticides
5.	acetamiprid
6.	Thiamethoxam
7.	thiacloprid
8.	Pesticides
9.	dinotefuran
10.	Guanidine (Guanidine Nitrate)

Related Therapies and Procedures

1.	Hemoperfusion
2.	Hemofiltration