Abstract |
Neonicotinoid insecticides have been widely used in plant protection against pests worldwide. Generally, more than one neonicotinoids are detected in plants and foods, and such mixtures may show combined toxicity and increase the risk for both insects and higher organisms. In this study, the combined toxicity of imidacloprid (IM), acetamiprid (AC) and thiamethoxam (TH) was investigated using human neuroblastoma cell line (SK-N-SH) and lepidopteran cell line (Sf-9). Results showed that binary and ternary mixtures could enhance the inhibition of growth of both SK-N-SH and Sf-9 cells at low doses. In SK-N-SH cells, based on CompuSyn software analysis, all the mixtures of IM+AC, IM+TH, AC+TH and IM+AC+TH showed synergistic effects at concentrations < 50 mg/L, but IM+AC, IM+TH showed antagonistic effects at higher concentrations. For Sf-9 cells, all mixtures revealed synergistic effects at low concentrations (< 0.1 mg/L) except IM+AC, showing antagonism at higher concentrations (> 0.5 mg/L). The toxicity thresholds of mixtures denoted by BMDL10 values were all lower than those for single pesticides and the combined BMDL10 value of AC+TH was the lowest one. It is concluded that the co-occurrence of several neonicotinoid insecticides may enhance their toxicity and aggravate the health risk for both insects and human.
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Authors | Lin Cheng, Yangyang Lu, Zhihui Zhao, Ron L A P Hoogenboom, Qicai Zhang, Xing Liu, Wei Song, Shuhui Guan, Weiguo Song, Qinxiong Rao |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 145
Pg. 111632
(Nov 2020)
ISSN: 1873-6351 [Electronic] England |
PMID | 32738377
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Neonicotinoids
- Nitro Compounds
- Pesticides
- imidacloprid
- acetamiprid
- Thiamethoxam
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Topics |
- Animals
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Drug Synergism
- Humans
- Neonicotinoids
(toxicity)
- Nitro Compounds
(toxicity)
- Pesticides
(toxicity)
- Sf9 Cells
- Thiamethoxam
(toxicity)
- Toxicity Tests
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