Anoctamin-1

An anoctamin chloride channel expressed at high levels in the liver, skeletal muscle, and gastrointestinal muscles that functions in transepithelial anion transport and smooth muscle contraction. It is essential for the function of the INTERSTITIAL CELLS OF CAJAL and plays a major role in chloride conduction by airway epithelial cells and in tracheal cartilage development.

Also Known As:

Networked: 97 relevant articles (0 outcomes, 18 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kunzelmann, Karl: 6 articles (04/2021 - 05/2014)
2.	Schreiber, Rainer: 6 articles (04/2021 - 05/2014)
3.	Namkung, Wan: 5 articles (09/2022 - 01/2015)
4.	Seo, Yohan: 5 articles (09/2022 - 01/2015)
5.	Ma, Ke: 5 articles (11/2021 - 08/2014)
6.	Xiao, Qinghuan: 5 articles (11/2021 - 11/2017)
7.	Liu, Mei: 4 articles (11/2021 - 01/2019)
8.	Wang, Hui: 4 articles (11/2021 - 11/2017)
9.	Tominaga, Makoto: 4 articles (07/2019 - 04/2015)
10.	Jo, Sungwoo: 3 articles (09/2022 - 01/2016)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2018 - "A previous study indicated that suppressed Anoctamin-1 expression decreased cancer cell proliferation or migration. " 08/01/2022 - "Overexpression of Ca2+-activated Cl- channel anoctamin 1 (ANO1) is shown in numerous cancer types and correlates with poor prognosis. " 01/01/2022 - "Anoctamin 1 (ANO1) has been observed to be overexpressed in gastrointestinal and pulmonary epithelial cells, as well as in a number of cancers. " 01/01/2022 - "there was no correlation between the TMEM16A protein expression and gender, age, tumor location, size and degree of differentiation (p > 0.05). " 01/29/2021 - "Anoctamin-1 (ANO1) plays a pivotal role in cancer progression. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2017 - "Our previous study indicated that transmembrane protein 16A (TMEM16A) contributed to migration and invasion of gastric cancer and predicted poor prognosis. " 02/01/2018 - "Inhibition of STAT6/Anoctamin-1 activation decreased proliferation, migration, or invasion of gastric cancer cells, suggesting that the STAT6/Anoctamin-1 pathway might be a novel target for treating gastric cancer." 02/01/2018 - "Inhibition of STAT6/Anoctamin-1 Activation Suppresses Proliferation and Invasion of Gastric Cancer Cells." 02/01/2018 - "Therefore, this study aimed to suppress STAT6 and Anoctamin-1 protein expression in gastric cancer cells to test the inhibitory effects on gastric cancer cell migration or invasion. " 02/01/2018 - "Interference of STAT6 or Anoctamin-1 reduced their protein expression and inhibited proliferation, migration, or invasion of gastric cancer cells. "
3.	Esophageal Squamous Cell Carcinoma 04/26/2016 - "Anoctamin 1 (ANO1) has been found to be overexpressed in esophageal squamous cell carcinoma (ESCC) in our previous study. " 01/01/2023 - "A recent study in this issue of Cancer Research by Deng and colleagues compared gene expression signatures between primary esophageal squamous cell carcinoma tumors and metastatic tumors and combined the analysis with genes induced in metastatic cancer cell lines, which identified anoctamin 1 (ANO1) as a key driver of metastasis. "
4.	Pain (Aches) 11/01/2021 - "Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl- channels have diverse physiological functions, such as epithelial secretion of Cl- and fluid and sensation of pain. " 11/01/2021 - "Increasing evidence suggests that transmembrane protein 16A (TMEM16A) in nociceptive neurons is an important molecular component contributing to peripheral pain transduction. " 01/01/2018 - "Recently, we showed that transient receptor potential vanilloid 1 (TRPV1) interacts with anoctamin 1 (ANO1, also called TMEM16A) in primary sensory neurons and that this interaction enhanced TRPV1-mediated pain sensation. " 09/12/2015 - "Anoctamin 1 (ANO1 or TMEM16A) Ca(2+)-gated Cl(-) channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. " 04/21/2015 - "Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons."
5.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 07/01/2012 - "Anoctamin-1 (ANO1) (DOG1, TMEM16a) is a calcium-activated chloride channel initially described in gastrointestinal stromal tumors, but now known to be expressed in a variety of normal and tumor tissues including salivary tissue in murine models. " 10/01/2015 - "DOG1 is a novel gene on gastrointestinal stromal tumors (GISTs) that encodes the chloride channel protein anoctamin 1, also known as discovered on GIST-1 (DOG1) protein. " 12/01/2014 - "The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal stromal tumor 1) plays an important role in facilitating the cell growth and metastasis of TMEM16A-expressing cancer cells. " 01/01/2017 - "Multiple studies have described the high expression and amplification of Anoctamin 1 (ANO1) in various cancers, including, but not limited to breast cancer, head and neck cancer, gastrointestinal stromal tumors and glioblastoma. " 03/19/2019 - "Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1, TMEM16A) was known as DOG1, a marker protein for gastrointestinal stromal tumors (GIST). "

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
3.	Iodides
4.	Proteins (Proteins, Gene)
5.	Chlorides
6.	Bestrophins
7.	Transforming Growth Factors (Transforming Growth Factor)
8.	Thyroid Hormones
9.	Sodium
10.	Oxygen (Dioxygen)

Related Therapies and Procedures

1.	Ligation
2.	Therapeutics
3.	Ovariectomy (Oophorectomy)
4.	Spinal Injections
5.	Percutaneous Collagen Induction