Heavy Metal Poisoning

Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of HEAVY METALS. Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women.

Also Known As:

Networked: 174 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lead Poisoning (Poisoning, Lead)
2.	Poisoning
3.	Neoplasms (Cancer)
4.	Carcinogenesis
5.	Polyneuropathies (Polyneuropathy)

Experts

1.	Li, Yuanfeng: 2 articles (06/2022 - 10/2021)
2.	Shen, Xiaoyun: 2 articles (06/2022 - 10/2021)
3.	Frazzoli, Chiara: 2 articles (04/2021 - 06/2019)
4.	Flora, S J S: 2 articles (04/2018 - 10/2008)
5.	Kushwaha, Pramod: 2 articles (04/2018 - 04/2014)
6.	Yadav, Abhishek: 2 articles (04/2018 - 04/2014)
7.	Sharma, Anuj K: 2 articles (01/2018 - 03/2010)
8.	Vatamaniuk, Olena K: 2 articles (01/2018 - 03/2010)
9.	He, Ying: 2 articles (10/2017 - 11/2016)
10.	Sun, Xiao: 2 articles (10/2017 - 11/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heavy Metal Poisoning:

1.	Succimer (Dimercaptosuccinic Acid)FDA Link 11/01/1988 - "14 patients with heavy metal poisoning received 2,3-dimercaptosuccinic acid (DMSA). " 11/01/1988 - "2,3-Dimercaptosuccinic acid treatment of heavy metal poisoning in humans." 05/01/1986 - "Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning." 10/15/2013 - "Analogs of BAL, less toxic, have been developed such as meso-2,3-dimercaptosuccinic acid (DMSA) and have been employed for the treatment of heavy metal poisoning. " 06/01/2009 - "2,3-Dimercaptosuccinic acid (DMSA) is an orally effective chelating agent for the treatment of heavy metal poisoning. "
2.	AntioxidantsIBA 09/01/2022 - "Oxido-inflammatory stress has been involved in lead-induced testicular dysfunction and plants rich in anti-oxidants has been reported to be beneficial in combating heavy metal poisonings in animal studies. " 06/01/2017 - "In conclusion, a deficiency of dietary and medicaments-derived antioxidants, while consumption of alcohol and tobacco, as well as effects of radiation, heavy metal poisoning (especially from sweeteners), and non-PPE using habits, may contribute cytogenetic damage to the workers." 12/01/2001 - "In order to prove the importance of using antioxidants in heavy metal poisoning, pertinent biochemical mechanisms for metal-induced oxidative stress should be reviewed." 10/01/2021 - "Previous several studies found that sulfur (S) and molybdenum (Mo) had the effect of alleviating the decrease of antioxidant capacity caused by heavy metal poisoning. " 11/01/2023 - "Selenium is an essential trace element and a powerful antioxidant that has been shown to have anti-inflammatory and antioxidant properties as well as alleviating heavy metal poisoning. "
3.	Heavy MetalsIBA 11/01/2023 - "At the same time, modern industrial agriculture will also bring a lot of environmental pollution in the development process, including the increase of heavy metal content, and often the clinical symptoms of low/medium level chronic heavy metal poisoning are not obvious, thus delaying the best treatment opportunity. " 04/01/2021 - "Evidence from scientific studies used in this review lends credence to the risk of heavy metal poisoning from donors with high blood concentrations of these heavy metals. " 09/28/2023 - "These efforts promote the development of simpler and faster techniques for heavy metal detection, thereby presenting novel avenues for the prevention and diagnosis of heavy metal poisoning." 02/24/2022 - "The impact and risk of heavy metal poisoning due to food consumption of mussels contaminated due to pollution of the marine harvesting area was evaluated by the bio-concentration factor of metals and estimated daily intakes of heavy metals through mussel consumption." 01/01/2022 - "This review mainly expounds various molecular mechanisms and progress of mitochondrial functional damage to explore the molecular mechanisms of heavy metal damage to mitochondrial functions, which provides a basis for the treatment of heavy metal poisoning, and protects the animal and animal-derived food safety from the source."
4.	Chelating AgentsIBA 02/01/1979 - "[Co-chelators inhibit heavy metal poisoning]." 08/01/1957 - "[Use of chelating agents in heavy metal poisoning]." 02/01/2022 - "Provoked urine testing (PUT), involving chelating agent administration prior to measuring urine metal excretion levels, is used by some alternative health care practitioners to diagnose patients with heavy metal poisoning. " 01/01/2022 - "Unithiol is a chelating agent which is routinely used to treat heavy metal poisoning. " 06/01/2019 - "The use of natural antidotes, which are easily available, affordable, and with little or no side effects compared to the classic metal chelators, is the focus of this review and suggested as cheaper options for developing nations in the treatment of heavy metal poisoning."
5.	ZincIBA 11/01/1994 - "The disadvantage of using rac-DMSA alone as a clinical antidote for heavy metal poisoning is that it causes a greater loss of endogenous zinc than its meso isomer. " 11/01/1994 - "These differences are reflected in the complex formation constants of the zinc(II) species and their distributions in solution as a function of zinc:ligand ratios and as a function of pH. On the basis of these results we have predicted that rac-DMSA is more effective than meso-DMSA in mobilizing lead in vivo and that the 1:2 zinc complex of rac-DMSA can be used effectively for the treatment of heavy metal poisoning because endogenous zinc will not be depleted by this chelation treatment." 10/23/2017 - "These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress. " 03/01/2014 - "Depleted uranium (DU) is a weak radioactive heavy metal, and zinc (Zn) is an effective antidote to heavy metal poisoning. "
6.	LigandsIBA 07/01/2015 - "They additionally demonstrate the potential utility of biologically-compatible ligands for the treatment of heavy metal poisoning." 05/01/2021 - "These results demonstrated that phosphate could restrict the binding affinity of heavy metals with different fluorescent substances or organic ligands of DOM, suggesting that the comigration of DOM-bound heavy metals in lakes is hindered by phosphate and the risk of heavy metal poisoning in aquatic organisms is therefore diminished." 10/09/2012 - "The ligands considered, DMSA and DMPS, are commonly used to treat heavy metal poisoning. " 11/01/1994 - "These differences are reflected in the complex formation constants of the zinc(II) species and their distributions in solution as a function of zinc:ligand ratios and as a function of pH. On the basis of these results we have predicted that rac-DMSA is more effective than meso-DMSA in mobilizing lead in vivo and that the 1:2 zinc complex of rac-DMSA can be used effectively for the treatment of heavy metal poisoning because endogenous zinc will not be depleted by this chelation treatment."
7.	IronIBA 03/01/2004 - "It also suggests that diets rich in iron-containing food could be protective against heavy metal poisoning." 01/01/2010 - "We offer a new perspective on certain Iron Age and Archaic (ca. 1,000-480 BC: ) Etruscan industrial and habitation sites, and on the problem of heavy metal poisoning, still being investigated today, coincidentally in some of the same areas that originally saw Etruscan mines and workshops. " 11/15/2020 - "Boosting the Alkali/Heavy Metal Poisoning Resistance for NO Removal by Using Iron-Titanium Pillared Montmorillonite Catalysts."
8.	EnzymesIBA 08/01/2016 - "Enzyme immobilization on a nanoadsorbent for improved stability against heavy metal poisoning." 08/01/2016 - "The enzyme grafting was shown to be a potentially perspective tool in alleviation of heavy metal poisoning and to be providing an opportunity for use of the developed adsorbents as both biosensors and bio-reactants for removal of urea from biofluids. " 01/01/1978 - "Liposomes are envisioned as pharmacological capsules for delivery of therapeutic agents in treatment of such conditions as diabetes, enzyme deficiencies, heavy metal poisoning, and neoplasms. "
9.	SolutionsIBA 11/01/1994 - "These differences are reflected in the complex formation constants of the zinc(II) species and their distributions in solution as a function of zinc:ligand ratios and as a function of pH. On the basis of these results we have predicted that rac-DMSA is more effective than meso-DMSA in mobilizing lead in vivo and that the 1:2 zinc complex of rac-DMSA can be used effectively for the treatment of heavy metal poisoning because endogenous zinc will not be depleted by this chelation treatment."
10.	Pentetic Acid (DTPA)FDA LinkGeneric 10/10/2021 - "Our results also show that CaDTPA injection is more potent for removing these metals than ZnDTPA and inhalation of CaDTPA, and DTPA may be useful for the treatment of acute heavy metal poisoning with Pb, Cd, or Hg."

Therapies and Procedures

1.	Therapeutics 08/01/1986 - "[Therapy of occupational heavy metal poisoning]." 12/01/1985 - "Therapy of acute heavy metal poisoning is currently limited to a group of moderately toxic drugs containing sulfhydryl groups. " 06/06/2019 - "Elucidating the characteristics and mechanisms of each heavy metal under the same experimental conditions will be helpful to understand the effect of heavy metals on health and to develop a more effective therapy for heavy metal poisoning." 12/01/1985 - "N-Acetylcysteine therapy of acute heavy metal poisoning in mice." 05/01/1953 - "[Dimercaptropropanol preparations in therapy of arsenic and heavy metal poisoning]."
2.	Chelation Therapy (Therapy, Chelation) 04/25/2018 - "Chelation therapy is the mainstream treatment for heavy metal poisoning. " 04/01/2014 - "Chelation therapy is a mainstream treatment used to treat heavy metal poisoning. " 06/01/2004 - "A diagnosis of heavy metal poisoning was made and chelation therapy was offered to each patient. " 08/01/2002 - "Chelation therapy originally was administered exclusively to patients with heavy metal poisoning. " 04/01/2007 - "We describe two cases of significant heavy metal poisonings (arsenic trioxide and mercuric chloride) that were successfully managed with aggressive decontamination and combined chelation therapy. "
3.	Glycemic Control 10/28/2005 - "LA improves glycemic control, reduces diabetic polyneuropathies, and mitigates toxicity associated with heavy metal poisoning. " 11/01/2008 - "Pharmacologically, LA improves glycemic control and polyneuropathies associated with diabetes mellitus; it also effectively mitigates toxicities associated with heavy metal poisoning. " 05/01/2004 - "Pharmacologically, LA improves glycemic control, polyneuropathies associated with diabetes mellitus, and effectively mitigates toxicities associated with heavy metal poisoning. "
4.	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/01/2022 - "However, the toxic and side effects of traditional Chinese medicine, especially heavy metal poisoning, should not be ignored. "
5.	Immunotherapy 01/01/2018 - "His failure to respond to immunotherapy prompted testing for heavy metal poisoning, which was positive for Mn. "