Abstract |
A recently developed methodology, which combines voltammetry, ITC, ESI-MS and several chemometric tools, has been applied for the first time to the study of As(III) complexes. The ligands considered, DMSA and DMPS, are commonly used to treat heavy metal poisoning. The study yields a reliable and consistent picture of the binding of As(III) by the chelating therapy agents DMSA and DMPS providing an unambiguous description of the stoichiometries of the complexes (ML(2), with the occasional appearance of ML in the case of DMSA), both ligands have stability constants of the same order, with a logβ(2) of 9.2 and 9.8, respectively. These values confirm the potential efficiency of both ligands in the treatment of As(III) poisoning.
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Authors | Santiago Cavanillas, Elena Chekmeneva, Cristina Ariño, José Manuel Díaz-Cruz, Miquel Esteban |
Journal | Analytica chimica acta
(Anal Chim Acta)
Vol. 746
Pg. 47-52
(Oct 09 2012)
ISSN: 1873-4324 [Electronic] Netherlands |
PMID | 22975179
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- Arsenates
- Chelating Agents
- Metals, Heavy
- Unithiol
- Succimer
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Topics |
- Arsenates
(analysis, chemistry)
- Arsenic Poisoning
(drug therapy)
- Calorimetry
(methods)
- Chelating Agents
(chemistry, therapeutic use)
- Electrochemical Techniques
- Heavy Metal Poisoning
- Humans
- Least-Squares Analysis
- Metals, Heavy
(antagonists & inhibitors)
- Normal Distribution
- Poisoning
- Spectrometry, Mass, Electrospray Ionization
(methods)
- Succimer
(chemistry, therapeutic use)
- Unithiol
(chemistry, therapeutic use)
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