Deprescriptions

Directions written to discontinue use of PRESCRIPTION DRUGS in order to reduce unnecessary and/or excessive medications (see POLYPHARMACY), DRUG SIDE EFFECTS and ADVERSE DRUG REACTION.

Also Known As:

Networked: 403 relevant articles (20 outcomes, 78 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Hilmer, Sarah N: 13 articles (10/2022 - 01/2015)
2.	Farrell, Barbara: 11 articles (07/2022 - 02/2017)
3.	Thompson, Wade: 10 articles (07/2022 - 02/2017)
4.	Reeve, Emily: 10 articles (01/2022 - 02/2014)
5.	Gnjidic, Danijela: 7 articles (01/2022 - 10/2015)
6.	Steinman, Michael A: 6 articles (10/2022 - 01/2019)
7.	Aspinall, Sherrie L: 6 articles (02/2022 - 09/2017)
8.	Niznik, Joshua D: 6 articles (02/2022 - 09/2017)
9.	Thorpe, Carolyn T: 6 articles (02/2022 - 09/2017)
10.	Welch, Vivian: 6 articles (01/2018 - 02/2017)

Related Diseases

1.	Drug-Related Side Effects and Adverse Reactions 01/01/2017 - "Continued efforts to improve clinicians' ability to make prescribing decisions, especially around deprescribing, have many potential benefits, including decreased pharmaceutical and health care costs, fewer adverse drug events and complications, and improved patient involvement and satisfaction with their care. " 03/01/2017 - "Studies focused on minimizing polypharmacy indicate that deprescribing may be associated with potential benefits including resolution of adverse drug reactions, improved quality of life and medication adherence and a reduction in drug costs. " 01/01/2021 - "Discussion: Factors that contribute to the growth of pediatric psychotropic polypharmacy include: (1) predominance of the biological model in psychiatric practice; (2) invalid assumptions on efficacy of combinations, (3) limited professional awareness of metabolic and neurological adverse drug events, and (4) infrequent use of appropriate deprescribing. " 12/01/2023 - "The MedSafer Study, a cluster randomized clinical trial in Canada, evaluated whether patient specific deprescribing reports generated by electronic decision support software resulted in reduced adverse drug events in the 30 days post hospital discharge in older adults (domain: deprescribing). " 03/01/2022 - "Scalable deprescribing interventions may reduce polypharmacy and the use of potentially inappropriate medications (PIMs); however, few studies have been large enough to evaluate the impact that deprescribing may have on adverse drug events (ADEs). "
2.	Sleep Initiation and Maintenance Disorders (Insomnia) 08/18/2022 - "CBT-I can be implemented in geriatric primary care with successful deprescribing of sleep medications and meaningful improvement in symptoms of insomnia in a group of older adults of advanced age with multiple medical problems. " 03/25/2023 - "In addition, medication side effects, interactions with co-administered medications, and declining therapeutic efficacy can necessitate switching between different insomnia medications or deprescribing altogether. " 07/20/2023 - "Reduction of Sleep Medications via a Combined Digital Insomnia and Pharmacist-Led Deprescribing Intervention: Protocol for a Feasibility Trial." 07/01/2021 - "The objective of this study is to evaluate an interprofessional SH deprescribing program within a community team-based, primary care practice, with or without cognitive behavioural therapy for insomnia (CBT-I). " 01/01/2018 - "Evidence was generated by conducting a systematic review of BZRA deprescribing trials for insomnia, as well as performing a review of reviews of the harms of continued BZRA use and narrative syntheses of patient preferences and resource implications. "
3.	Pain (Aches) 11/22/2023 - "Most patients on LTOT report ineffectiveness (poor pain control, function, and health), but still find deprescribing challenging. " 11/01/2023 - "We designed a national intervention that included audit and feedback, deprescribing guidance, information on catastrophising assessment, pain neuroscience education and a cognitive tool for use by patients with their healthcare providers. " 06/01/2021 - "This review article provides the interdisciplinary team with a contemporary perspective of the multitude of changes and challenges influencing the prescribing as well as deprescribing of various pain medications." 01/01/2019 - "To determine the proportion of GPs who hold attitudes congruent with local pain stewardship, describe their deprescribing decisions, and determine whether type of POA influences deprescribing. " 01/01/2017 - "This article describes a pharmacist-led, patient-centred approach to deprescribing in a 73-year-old diabetic man taking multiple medication, with gastrointestinal (GI) and pain symptoms as well as poor adherence to medicines. "
4.	Dementia (Dementias) 11/01/2021 - " covered:Non-systematic searches of key databases including PubMed, Embase, and Google Scholar were conducted from inception to 28 February 2021 for articles that assessed the safety and/or efficacy of deprescribing in older adults living with dementia. " 10/02/2023 - "Findings from this national survey study of primary care physicians suggests that understanding ethical aspects of physician decision-making can inform clinician education about medication management and deprescribing decisions for older adults with moderate dementia." 12/01/2022 - "Psychotropic medication deprescribing in residential aged care facilities: An exploratory study of the knowledge and attitudes of family members of residents with dementia." 04/01/2022 - "This study highlights the importance of a multidisciplinary approach in addressing drug-therapy problems, medication optimisation, and deprescription in patients with dementia. " 11/01/2021 - "This study aims to define the prevalence of patients admitted to a palliative care unit (PCU) with dementia on a CHEI and to determine whether these patients were tapered off their CHEIs according to current deprescribing guidelines. "
5.	Neoplasms (Cancer) 10/17/2023 - "Emotional barriers and facilitators of deprescribing for older adults with cancer and polypharmacy: a qualitative study." 09/01/2020 - "This study shows the positive impact a PCC has on deprescribing and reveals the importance of using guidelines for deprescribing in palliative cancer patients." 01/01/2019 - "Content analysis was used to analyze qualitative interviews with nurses from a parent study exploring views on medication management and deprescribing for advanced cancer patients. " 01/01/2015 - "The aims of this study were to design and validate a deprescribing guideline for palliative cancer patients and to undertake a descriptive analysis of the identified PIMs. " 12/01/2023 - "We used "deprescribing," "potentially inappropriate medication" and "cancer" as a keyword for the conducting general search. "

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Benzodiazepines
3.	Hypnotics and Sedatives (Sedatives)
4.	Anticoagulants
5.	Anticonvulsants (Antiepileptic Drugs)
6.	Cholinergic Antagonists (Anticholinergics)
7.	Analgesics (Analgesic Drugs)
8.	Opiate Alkaloids
9.	Morphine (MS Contin)
10.	5-methoxy-methylindoleacetic acid (DBI)

Related Therapies and Procedures

1.	Polypharmacy
2.	Deprescriptions
3.	Therapeutics
4.	Opiate Substitution Treatment
5.	Home Nursing (Nursing, Home)