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N- hydroxy- 2- (1- phenylcycloproylamino)pyrimidine- 5- carboxamide

Also Known As:

ACY-738

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Hydroxamic Acids: 239
      - N-hydroxy-2-(1-phenylcycloproylamino)pyrimidine-5-carboxamide: 3
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxamic Acids: 239
      - N-hydroxy-2-(1-phenylcycloproylamino)pyrimidine-5-carboxamide: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - N-hydroxy-2-(1-phenylcycloproylamino)pyrimidine-5-carboxamide: 3

Experts

1.	Basrai, Reemsha: 1 article (04/2021)
2.	Cheng, Alice: 1 article (04/2021)
3.	Deleyrolle, Loic P: 1 article (04/2021)
4.	Hoang-Minh, Lan B: 1 article (04/2021)
5.	Kalaria, Neil: 1 article (04/2021)
6.	Khoshbouei, Habibeh: 1 article (04/2021)
7.	Lebowitz, Joseph J: 1 article (04/2021)
8.	Sarkisian, Matthew R: 1 article (04/2021)
9.	Shi, Ping: 1 article (04/2021)
10.	Tian, Jia: 1 article (04/2021)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2019 - "In this study, experimental autoimmune encephalomyelitis (EAE) mice, an animal model of MS, were treated with the HDAC6 inhibitor drug ACY-738 (20 mg/kg) on day 9 and day 10 post-immunization. "
2.	Multiple Sclerosis 01/01/2019 - "The Selective HDAC6 Inhibitor ACY-738 Impacts Memory and Disease Regulation in an Animal Model of Multiple Sclerosis."
3.	Inflammation (Inflammations) 07/01/2020 - "We also demonstrate that ACY-738 and ACY-257 attenuate mechanical allodynia in the CFA model of peripheral inflammation. "
4.	Hyperalgesia 07/01/2020 - "Using the SNI model, we demonstrate that daily administration of the brain-penetrant HDAC6 inhibitor, ACY-738, abolishes mechanical allodynia in male and in female mice. " 07/01/2020 - "We also demonstrate that ACY-738 and ACY-257 attenuate mechanical allodynia in the CFA model of peripheral inflammation. "
5.	Glioma (Gliomas) 04/01/2021 - "We found that HDAC6 inhibitors ACY-1215 (1215) and ACY-738 (738) inhibited the proliferation of multiple patient-derived and mouse glioma cells. "

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