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9- methoxy- 6- (piperazin- 1- yl)- 11H- indeno(1,2- c)quinoline- 11- one O-3-(dimethylamino)propyl oxime

structure in first source

Also Known As:

TCH-1030; TCH1036

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Hydroxylamines: 16
    - Oximes: 1292
      - 9-methoxy-6-(piperazin-1-yl)-11H-indeno(1,2-c)quinoline-11-one O-3-(dimethylamino)propyl oxime: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 9-methoxy-6-(piperazin-1-yl)-11H-indeno(1,2-c)quinoline-11-one O-3-(dimethylamino)propyl oxime: 2

Experts

1.	Chen, Yeh-Long: 2 articles (08/2016 - 04/2013)
2.	Tseng, Chih-Hua: 2 articles (08/2016 - 04/2013)
3.	Tzeng, Cherng-Chyi: 2 articles (08/2016 - 04/2013)
4.	Chang, Jan-Gowth: 1 article (08/2016)
5.	Chang, Ya-Sian: 1 article (08/2016)
6.	Chen, Jui-Chang: 1 article (08/2016)
7.	Chen, Yi-Fong: 1 article (08/2016)
8.	Hsiao, Pei-Chi: 1 article (08/2016)
9.	Lee, Chien-Chin: 1 article (08/2016)
10.	Liao, Hsien-Feng: 1 article (08/2016)

Related Diseases

1.	Glioma (Gliomas) 08/01/2016 - "In this study, we further explore the activity of the TCH1036, TCH1259 and TCH1030 compounds in suppressing the growth of human brain malignant glioma (GBM) 8401 cells, in addition to elucidating the related mechanisms. " 08/01/2016 - "These findings suggested that the TCH1036 compound would be a promising compound in the treatment of brain malignant glioma. " 08/01/2016 - "TCH1036, a indeno[1,2-c]quinoline derivative, potentially inhibited the growth of human brain malignant glioma (GBM) 8401 cells via suppression of the expression of Suv39h1 and PARP."
2.	Polyploidy 04/01/2013 - "Flow cytometric analysis and BrdU incorporation assays indicate that TCH-1030 alters cell cycle progression, induces S-phase arrest, and causes DNA polyploidy (>4 N) that is distinct from the typical G2-M arrest reported with known topoisomerase toxins. "
3.	Neoplasms (Cancer) 04/01/2013 - "We also demonstrated that treatment with TCH-1030 significantly inhibits tumor growth in a BT483-xenograft nude mouse model. "
4.	Breast Neoplasms (Breast Cancer) 04/01/2013 - "TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells."

Related Drugs and Biologics

1.	Type I DNA Topoisomerases (Topoisomerase I)
2.	DNA (Deoxyribonucleic Acid)
3.	Bromodeoxyuridine (BrdU)
4.	quinoline