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cindunistat

Also Known As:

SD-6010; cindunistat hydrochloride maleate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - Cysteine: 6760
      - cindunistat: 2
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - cindunistat: 2
- Amidines: 14
  - cindunistat: 2
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Sulfur Amino Acids: 221
    - Cysteine: 6760
      - cindunistat: 2
  - Neutral Amino Acids: 200
    - Cysteine: 6760
      - cindunistat: 2

Experts

1.	Azzolina, Danila: 1 article (12/2018)
2.	Barbetta, Beatrice: 1 article (12/2018)
3.	Giacovelli, Giampaolo: 1 article (12/2018)
4.	Gregori, Dario: 1 article (12/2018)
5.	Gualtieri, Francesca: 1 article (12/2018)
6.	Minto, Clara: 1 article (12/2018)
7.	Rovati, Lucio C: 1 article (12/2018)
8.	Vaghi, Paola: 1 article (12/2018)
9.	Abramson, Steven B: 1 article (02/2013)
10.	Brandt, Kenneth D: 1 article (02/2013)

Related Diseases

1.	Osteoarthritis 02/01/2013 - "To determine if inhibition of inducible nitric oxide synthase (iNOS) with cindunistat hydrochloride maleate slows progression of osteoarthritis (OA) METHODS: This 2-year, multinational, double-blind, placebo-controlled trial enrolled patients with symptomatic knee OA (Kellgren and Lawrence Grade (KLG) 2 or 3). " 12/25/2018 - "Forty-seven RCTs (22 037 patients; mean age range, mostly 55-70 years; and a higher mean proportion of women than men, around 70%) included the following medication categories: analgesics; antioxidants; bone-acting agents such as bisphosphonates and strontium ranelate; nonsteroidal anti-inflammatory drugs; intra-articular injection medications such as hyaluronic acid and corticosteroids; symptomatic slow-acting drugs in osteoarthritis such as glucosamine and chondroitin sulfate; and putative disease-modifying agents such as cindunistat and sprifermin. "
2.	Knee Osteoarthritis 02/01/2013 - "A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee."
3.	Arthralgia (Joint Pain) 02/01/2013 - "Cindunistat did not improve joint pain or function, but was generally well tolerated. "

Related Drugs and Biologics

1.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
2.	Hyaluronic Acid (Hyaluronan)
3.	Glucosamine (Dona)
4.	Diphosphonates (Bisphosphonates)
5.	Chondroitin Sulfates (Chondroitin Sulfate)
6.	Antioxidants
7.	Analgesics (Analgesic Drugs)
8.	Adrenal Cortex Hormones (Corticosteroids)
9.	fibroblast growth factor 18
10.	strontium ranelate (protelos)

Related Therapies and Procedures

1.	Intra-Articular Injections