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palmostatin B

inhibits acyl protein thioesterase 1; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 140
- Lactones: 1590
  - Propiolactone: 105
    - palmostatin B: 2

Experts

1.	Chen, Bing: 1 article (01/2023)
2.	Li, Yaming: 1 article (01/2023)
3.	Liang, Yiran: 1 article (01/2023)
4.	Liu, Ying: 1 article (01/2023)
5.	Liu, Yiwei: 1 article (01/2023)
6.	Luo, Dan: 1 article (01/2023)
7.	Su, Peng: 1 article (01/2023)
8.	Wang, Lijuan: 1 article (01/2023)
9.	Wang, Xiaolong: 1 article (01/2023)
10.	Yang, Qifeng: 1 article (01/2023)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 02/09/2016 - "Finally, we test the dual APT-1 and APT-2 inhibitor palmostatin B and conclude that palmostatin B has effects on NRAS downstream signaling and cell viability in NRAS mutant melanoma cells, offering an interesting starting point for future studies." 02/09/2016 - "Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells."
2.	Triple Negative Breast Neoplasms 01/01/2023 - ": ACTB: actin beta; 5-aza: 5-azacytidine; BNIP3: BCL2 interacting protein 3; BNIP3L: BCL2 interacting protein 3 like; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; ChIP: chromatin immunoprecipitation; co-IP: co-immunoprecipitation; CQ: chloroquine; CsA: cyclosporine; DOX: doxorubicin; FIS1: fission, mitochondrial 1; FUNDC1: FUN14 domain containing 1; GPCPD1: glycerophosphocholine phosphodiesterase 1; HAM: hydroxylamine; HIF1A: hypoxia inducible factor 1 subunit alpha; HRE: hypoxia response element; IF: immunofluorescence; LB: lysis buffer; LC3B/MAP1LC3B: microtubule associated protein 1 light chain 3 beta; LC-MS: liquid chromatography-mass spectrometry; LYPLA1: lysophospholipase 1; LYPLA2: lysophospholipase 2; MDA231: MDA-MB-231; MDA468: MDA-MB-468; MFN1: mitofusin 1; MFN2: mitofusin 2; MKI67: marker of proliferation Ki-67; OCR: oxygen consumption rate; OMM: outer mitochondrial membrane; OS: overall survival; PalmB: palmostatin B; PBS: phosphate-buffered saline; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; SDS: sodium dodecyl sulfate; TOMM20: translocase of outer mitochondrial membrane 20; TNBC: triple-negative breast cancer; VBIT-4: VDAC inhibitor; VDAC1: voltage dependent anion channel 1; WT: wild type."
3.	Hypoxia (Hypoxemia) 01/01/2023 - ": ACTB: actin beta; 5-aza: 5-azacytidine; BNIP3: BCL2 interacting protein 3; BNIP3L: BCL2 interacting protein 3 like; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; ChIP: chromatin immunoprecipitation; co-IP: co-immunoprecipitation; CQ: chloroquine; CsA: cyclosporine; DOX: doxorubicin; FIS1: fission, mitochondrial 1; FUNDC1: FUN14 domain containing 1; GPCPD1: glycerophosphocholine phosphodiesterase 1; HAM: hydroxylamine; HIF1A: hypoxia inducible factor 1 subunit alpha; HRE: hypoxia response element; IF: immunofluorescence; LB: lysis buffer; LC3B/MAP1LC3B: microtubule associated protein 1 light chain 3 beta; LC-MS: liquid chromatography-mass spectrometry; LYPLA1: lysophospholipase 1; LYPLA2: lysophospholipase 2; MDA231: MDA-MB-231; MDA468: MDA-MB-468; MFN1: mitofusin 1; MFN2: mitofusin 2; MKI67: marker of proliferation Ki-67; OCR: oxygen consumption rate; OMM: outer mitochondrial membrane; OS: overall survival; PalmB: palmostatin B; PBS: phosphate-buffered saline; PINK1: PTEN induced kinase 1; PRKN: parkin RBR E3 ubiquitin protein ligase; SDS: sodium dodecyl sulfate; TOMM20: translocase of outer mitochondrial membrane 20; TNBC: triple-negative breast cancer; VBIT-4: VDAC inhibitor; VDAC1: voltage dependent anion channel 1; WT: wild type."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Hypoxia-Inducible Factor 1
3.	Voltage-Dependent Anion Channel 1
4.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
5.	Hydroxylamine (Hydroxylamine Hydrochloride)
6.	Cyclosporine (Ciclosporin)
7.	Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)
8.	Phosphotransferases (Kinase)
9.	Phosphates (Orthophosphate)
10.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)