gomesin

01/01/2017 - "In the current study, we were interested in improving the antimicrobial properties of the cyclic gomesin, understanding its selectivity toward melanoma cells and elucidating its antimicrobial and anticancer mode of action. "
01/01/2018 - "Concordantly, gomesin-treated melanoma cells showed a reduced G0/G1 cell population. "
01/01/2018 - "Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation."
01/01/2018 - "Taken together, our data highlight the potential of gomesin for development as a novel melanoma-targeted therapy."
01/01/2008 - "A direct cytotoxicity of gomesin in murine melanoma B16F10-Nex2 cells and several human tumor cell lineages was observed in vitro, with IC(50) values below 5 microM. "

03/06/2012 - "In this study, we evaluate the efficacy of gomesin treatment on disseminated and vaginal candidiasis as well as its toxicity and biodistribution. "

03/06/2012 - "Gomesin proved to be effective against experimental Candida albicans infection. "
11/28/2022 - "To explore the use of [G1K,K8R]cGm, a designed cyclic analogue of the antimicrobial peptide gomesin, as an alternative approach to treat biofilm infections. "
03/06/2012 - "Gomesin's mechanism is not fully understood, but we hypothesise that the peptide acts through the permeabilisation of the yeast membrane leading to death and/or releasing the yeast antigens that trigger the host immune response against infection. "

01/01/2021 - "In the current study, we employed a range of biophysical methodologies with model membranes and bioassays to investigate the use of a cyclic analogue of gomesin as a drug scaffold to internalize cancer cells. "
03/18/2013 - "The current study demonstrates that cyclization improves the in vitro stability of gomesin over a 24 hour time period and enhances cytotoxicity against a cancer cell line without being toxic to a noncancerous cell line. "
03/20/2023 - "In recent years, a cyclic version of gomesin has been used for drug design and development as it is more stable than native gomesin in human serum and can penetrate and enter cancer cells. "
03/20/2023 - "Gomesin exhibits a range of biological activities, as demonstrated by its toxicity against therapeutically relevant pathogens such as Gram-positive or Gram-negative bacteria, fungi, cancer cells, and parasites. "
01/01/2021 - "We found that cyclic gomesin can internalize cancer cells via endocytosis and direct membrane permeation. "

07/30/2010 - "In this study, the cytotoxic mechanism of gomesin in human neuroblastoma SH-SY5Y and rat pheochromocytoma PC12 cells was investigated. "