HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Zymocel

betafectin is a soluble hydrolysis product of zymocel

Also Known As:

poly-(1-6)-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyranose polymer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Glucans: 1624
      - Zymocel: 2
Carbohydrates: 22023
- Polysaccharides: 15383
  - Glucans: 1624
    - Zymocel: 2

Experts

1.	Dranoff, G: 1 article (01/2001)
2.	Miyakawa, K: 1 article (01/2001)
3.	Miyata, E: 1 article (01/2001)
4.	Takahashi, K: 1 article (01/2001)
5.	Takeya, M: 1 article (01/2001)
6.	Wynn, A A: 1 article (01/2001)

Related Diseases

1.	Sarcoma 180 12/01/1996 - "Zymocel also showed anti-tumour activity against sarcoma 180 in mice and also enhanced TNF synthesis and hydrogen peroxide production by macrophage-like cell line in-vitro, i.e. "
2.	Necrosis 12/01/1996 - "Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia. "
3.	Leukopenia 12/01/1996 - "Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia. "
4.	Granuloma 01/01/2001 - "The DNA nick-end-labeling method demonstrated increased numbers of apoptotic cells in and around hepatic granulomas of GM-CSF(-/-) mice from 8 days after zymocel injection, and electron microscopy detected apoptotic bodies. " 01/01/2001 - "To examine the role of granulocyte/macrophage colony-stimulating factor (GM-CSF) in inflammatory granuloma formation, we injected GM-CSF-deficient (GM-CSF(-/-)) mice and wild-type (GM-CSF(+/+)) mice intravenously with 2 mg of zymocel, and mice were killed at various intervals for examination. " 01/01/2001 - "Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation." 01/01/2001 - "In GM-CSF(-/-) mice, we demonstrated a marked delay of zymocel-induced hepatic granuloma formation until 5 days after zymocel injection with a rapid reduction in numbers of granulomas at 10 days until their disappearance. "

Related Drugs and Biologics

1.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Lipopolysaccharides
4.	Hydrogen Peroxide (Hydroperoxide)
5.	Evans Blue (Blue, Evans)
6.	Dihydrotachysterol (AT 10)
7.	Cyclophosphamide (Cytoxan)