|1.||Duca, Laurent: 2 articles (03/2015 - 12/2014)|
|2.||Bellon, Georges: 2 articles (12/2009 - 06/2002)|
|3.||Chatron-Colliet, Aurore: 1 article (03/2015)|
|4.||Rusciani, Anthony: 1 article (03/2015)|
|5.||Kurdykowski, Sandrine: 1 article (03/2015)|
|6.||Ploton, Dominique: 1 article (03/2015)|
|7.||Bobichon, Hélène: 1 article (03/2015)|
|8.||Lorenzato, Marianne: 1 article (03/2015)|
|9.||Terryn, Christine: 1 article (03/2015)|
|10.||Lalun, Nathalie: 1 article (03/2015)|
|1.||Chronic Obstructive Pulmonary Disease (COPD)
05/01/2013 - "Patients with exacerbated COPD were unresponsive to VGVAPG treatment. "
05/01/2013 - "VGVAPG increased proinflammatory cytokine synthesis and bacterial load, but reduced ROS production in neutrophils from controls and from patients with stable COPD. "
05/01/2013 - "Chemotactic activity of neutrophils from patients with COPD towards the VGVAPG EP was reduced compared with controls. "
05/01/2013 - "The study demonstrates that the response of neutrophils from patients with COPD to VGVAPG varied according to COPD phase and critical level of S-Gal expression. "
11/01/2010 - "A hexapeptide VGVAPG, which had been widely studied for its chemotactic activity for a possible pathogenic role in COPD, was not detected in lung EDPs by HNE or MMP12 digestion, but only by porcine pancreatic elastase (PPE) digestion. "
11/01/1988 - "These results suggest that M27 tumor cell chemotaxis to VGVAPG is initiated by high affinity binding of the peptide to a distinct cell surface receptor."
11/01/1988 - "Scatchard analysis of [125I]Y-VGVAPG binding to viable M27 tumor cells at both 37 and 4 degrees C indicates the presence of a single class of high affinity binding sites. "
06/25/1989 - "We conclude that chemotactic responsiveness of M27 and H59 tumor cells is dependent upon high VGVAPG receptor affinity, which is strongly correlated to high levels of membrane-bound protein kinase C activity."
11/01/1988 - "We have found that certain tumor cells display a chemotactic response to degradation products of the matrix protein elastin, and to an elastin-derived peptide, VGVAPG. "
11/01/1988 - "Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide."
|3.||Lewis Lung Carcinoma
11/01/1988 - "The hexapeptide VGVAPG is a particularly potent chemotaxin for lung-colonizing Lewis lung carcinoma cells (line M27), with 5 nM VGVAPG eliciting maximal chemotactic response when assayed in 48-microwell chemotaxis chambers. "
06/01/1993 - "Reduced VGVAPG receptor affinity was previously observed: (a) a nonresponsive Lewis lung carcinoma variant, H59, expresses low-affinity VGVAPG binding and (b) maintenance of high-affinity VGVAPG receptors on M27 tumor cells is correlated with elevated protein kinase C activity in the particulate cell fraction (C. "
06/01/1993 - "Chemotaxis of the M27 variant of Lewis lung carcinoma to VGVAPG, an elastin-derived chemoattractant, is restricted by the basement membrane glycoprotein laminin. "
06/25/1989 - "The M27 and H59 variants of Lewis lung carcinoma differ in their responsiveness to the chemotactic elastin peptide Val-Gly-Val-Ala-Pro-Gly (VGVAPG). "
|4.||Melanoma (Melanoma, Malignant)
03/01/2015 - "The elastin peptide (VGVAPG)3 induces the 3D reorganisation of PML-NBs and SC35 speckles architecture, and accelerates proliferation of fibroblasts and melanoma cells."
05/01/2008 - "Elastin, tropoelastin and VGVAPG peptide were demonstrated at the invasion site of melanoma using histochemistry and immunohistochemistry. "
05/01/2008 - "The effects of the elastin-derived peptides VGVAPG and VAPG have been investigated on the migration, invasion, adhesion and angiogenesis of human melanoma cells of different invasive potential. "
05/01/2008 - "Locally generated VGVAPG and VAPG elastin-derived peptides amplify melanoma invasion via the galectin-3 receptor."
05/01/2008 - "Our results suggest that the increased levels of elastin-derived peptides facilitate the invasion of melanoma cells: (i) VGVAPG and VAPG elastin-derived peptides are chemotactic for melanoma cells; (ii) they can increase the migration of melanoma cells and the expression of CXCR-4 and CXCL-12 chemokines; (iii) they enhance the expression of the elastin-degrading MMP-2 and MMP-3; (iv) they increase the attachment of melanoma cells and the expression of different adhesion molecules; (v) they increase the expression of the lymphangiogenic VEGF-C and (vi) the galectin-3 receptor can mediate all these effects. "
12/01/2014 - "We confirmed these results in vivo by demonstrating that both kappa-elastin and VGVAPG significantly prolonged the time for complete arteriole occlusion in a mouse model of thrombosis and increased tail bleeding times. "
12/01/2014 - "In a mouse whole blood perfusion assay over a collagen matrix, kappa-elastin and VGVAPG, the canonical peptide recognizing the elastin receptor complex, significantly decrease thrombus formation under arterial shear conditions. "
|3.||Protein Kinase C
|4.||Matrix Metalloproteinase 14 (MT1-MMP)
|5.||Vascular Endothelial Growth Factor C
|6.||Galectin 3 (LGALS3)
|10.||Pancreatic Elastase (Elastase)