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Protein Kinase C

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
Also Known As:
Phospholipid-Sensitive Calcium-Dependent Protein Kinase; Protein Kinase M; Calcium Activated Phospholipid Dependent Kinase; Calcium Phospholipid Dependent Protein Kinase; PKC Serine Threonine Kinase; Phospholipid Sensitive Calcium Dependent Protein Kinase; Phospholipid-Dependent Kinase, Calcium-Activated; Serine-Threonine Kinase, PKC; Calcium Phospholipid-Dependent Protein Kinase; Calcium-Activated Phospholipid-Dependent Kinase; PKC Serine-Threonine Kinase
Networked: 5856 relevant articles (90 outcomes, 602 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Leitges, Michael: 23 articles (01/2021 - 10/2003)
2. Kazanietz, Marcelo G: 23 articles (01/2019 - 01/2002)
3. Mochly-Rosen, Daria: 23 articles (10/2011 - 06/2002)
4. King, George L: 21 articles (10/2017 - 09/2002)
5. Li, Tao: 15 articles (10/2017 - 06/2006)
6. Blumberg, Peter M: 14 articles (01/2019 - 01/2002)
7. Irie, Kazuhiro: 12 articles (07/2022 - 06/2009)
8. Fields, Alan P: 12 articles (01/2017 - 06/2002)
9. Strasser, Ruth H: 12 articles (01/2013 - 05/2002)
10. Newton, Alexandra C: 11 articles (01/2022 - 01/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Ischemia
3. Reperfusion Injury
4. Hypoxia (Hypoxemia)
5. Mania (Manias)

Related Drugs and Biologics

1. Tamoxifen
2. Protein Isoforms (Isoforms)
3. Calcium
4. Type C Phospholipases
5. Mitogen-Activated Protein Kinases
6. Protein Kinases (Protein Kinase)
7. Proteins (Proteins, Gene)
8. Phosphotransferases (Kinase)
9. Enzymes
10. Staurosporine

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Liver Transplantation
4. Oral Administration
5. Injections