U 44069

has contractile effect on rat pulmonary veins & arteries; a thromboxane-A2 mimetic

Also Known As:

U-44069; U44069

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandin Endoperoxides: 1
        U 44069: 9
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Synthetic Prostaglandins: 823
    - Synthetic Prostaglandin Endoperoxides: 1
      - U 44069: 9
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandin Endoperoxides: 1
        U 44069: 9

Experts

1.	Bailey, S R: 1 article (06/2013)
2.	Borer, K E: 1 article (06/2013)
3.	Elliott, J: 1 article (06/2013)
4.	Harris, P A: 1 article (06/2013)
5.	Brigham, Kenneth L: 1 article (12/2005)
6.	Cuppels, Chris: 1 article (12/2005)
7.	Lawrence, E Clinton: 1 article (12/2005)
8.	Mottola, David: 1 article (12/2005)
9.	Parker, Richard E: 1 article (12/2005)
10.	Sandifer, Brett L: 1 article (12/2005)

Related Diseases

1.	Pulmonary Hypertension 12/01/2005 - "Acute, stable pulmonary hypertension was induced in instrumented unanesthetized sheep by infusing a PGH(2) analog, U-44069. " 05/01/2001 - "In contrast, injecting the thromboxane A2 mimetic U44069 during the endotoxin recovery period triggered pulmonary vasoconstriction and pulmonary hypertension similar in magnitude to the responses triggered by U44069 before endotoxin had been administered. " 04/01/1990 - "DMTU also did not ameliorate pulmonary hypertension evoked by the thromboxane mimetic U44069, thereby suggesting that the scavenger did not act as an end-organ antagonist of thromboxane receptors. "
2.	Whooping Cough (Pertussis) 03/15/1986 - "Treatment of membranes with either cholera or pertussis toxins, which inhibited markedly the receptor-mediated stimulation of the GTPase activities of Ns and Ni respectively, had no or only a small effect, respectively, on the GTPase activity stimulated by PAF and U44069. "
3.	Thrombocytopenia (Thrombopenia) 03/15/1988 - "In experiments in mice in vivo, CV-4151 (1 and 10 mg/kg i.v.) significantly inhibited the thrombocytopenia induced by U-44069 in a dose-dependent manner. "
4.	Cholera 03/15/1986 - "Treatment of membranes with either cholera or pertussis toxins, which inhibited markedly the receptor-mediated stimulation of the GTPase activities of Ns and Ni respectively, had no or only a small effect, respectively, on the GTPase activity stimulated by PAF and U44069. "
5.	Carcinoma (Carcinomatosis) 02/15/1984 - "The endoperoxide analogs known as U-46619 and U-44069 significantly enhanced the carcinoma formation and cellular atypicality initiated by a chemical carcinogen in mice. "

Related Drugs and Biologics

1.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2.	Purinergic P1 Receptor Agonists
3.	Prostaglandin H2 (PGH(2))
4.	GTP Phosphohydrolases (GTPases)
5.	Adenosine-5'-(N-ethylcarboxamide) (NECA)
6.	Thromboxane Receptors (Thromboxane Receptor)
7.	Dinoprostone (PGE2)
8.	Vasodilator Agents (Vasodilators)
9.	Thromboxanes
10.	Thromboxane A2 (A2, Thromboxane)