|1.||Ludwig, Bernd: 2 articles (06/2012 - 05/2011)|
|2.||Hannappel, Achim: 2 articles (06/2012 - 05/2011)|
|3.||Bundschuh, Freya A: 2 articles (06/2012 - 05/2011)|
|4.||Leary, Scot C: 2 articles (05/2008 - 01/2003)|
|5.||Hamazaki, Tomohito: 1 article (03/2015)|
|6.||Langsjoen, Peter H: 1 article (03/2015)|
|7.||Hama, Rokuro: 1 article (03/2015)|
|8.||Kobayashi, Tetsuyuki: 1 article (03/2015)|
|9.||Okuyama, Harumi: 1 article (03/2015)|
|10.||Ogushi, Yoichi: 1 article (03/2015)|
10/01/2005 - "Heme a,a3 content and turnover number increased by 1.5-fold during hypoxemia. "
10/01/1998 - "Therefore, the rapid phase of the reduction of heme a + a3 can be used as an alarm before a decrease in ATP, whereas the reduction of copper indicates a decrease in ATP under severe hypoxia. "
09/20/1968 - "Effect of oxygen deficiency on cytochrome c, heme a, and iron protoporphyrin of L-cells."
12/23/1977 - "The copper atom associated with heme a3 did not respond to anoxia and may be reduced under normoxic conditions, whereas the heme-a copper was at least partially reducible."
01/01/2002 - "For example, heme (protein) senses oxygen concentration to regulate hypoxia response genes such as erythropoietin, and free heme, a proxidant, controls levels of several oxidative stress response proteins as well as that of a few enzymes in the heme metabolic pathway. "
|2.||Cytochrome-c Oxidase Deficiency
05/02/2008 - "In contrast, CCS/G93A SOD1 mouse spinal cord showed no reduction in levels of selected subunits from complexes I, II, III, or V. Heme A analyses of spinal cord further support the existence of cytochrome c oxidase deficiency in CCS/G93A SOD1 mice. "
05/01/2000 - "A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency."
07/25/1997 - "The cytochrome oxidase deficiency also does not appear to be related to mitochondrial copper metabolism or heme a biosynthesis. "
|3.||Leigh Disease (Leigh's Disease)
05/01/2011 - "Surf1, associated with heme a insertion and with Leigh syndrome if defective in humans, is present as two homologs in the soil bacterium Paracoccus denitrificans, Surf1c and Surf1q. "
05/01/2005 - "We describe a patient with atypical, long surviving Leigh syndrome carrying two novel mutations in the COX15 gene, which encodes an enzyme involved in the biosynthesis of heme A. "
06/01/2012 - "denitrificans Surf1 protein shed some light on this important assembly factor as a heme a binding protein associated with Leigh syndrome in humans. "
03/01/2015 - "In contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis, we present a perspective that statins may be causative in coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and 'heme A', and thereby ATP generation. "
|5.||Lewy Body Disease (Lewy Body Dementia)
09/25/2009 - "We measured heme-a levels in postmortem brain tissue from nine patients diagnosed with dementia: Alzheimer's disease (AD) was the primary diagnosis in five, AD/diffuse Lewy body disease (DLBD) was diagnosed in two, DLBD was diagnosed in one, and DLBD (severe)/AD (mild) was diagnosed in one. "
|5.||Electron Transport Complex IV (Cytochrome c Oxidase)
|6.||Adenosine Triphosphate (ATP)
|9.||Cytochromes c (Cytochrome c)
|10.||Small Interfering RNA (siRNA)