09/01/1980 - "To define the metabolism of 7-ketolithocholic acid in man, studies were carried out in gallstone patients with normal liver function. "
08/01/1982 - "The reduction in biliary lithogenic index and in cholesterol concentration suggest that low doses of 7-ketolithocholic acid may be effective in dissolving gallstones."
08/01/1982 - "The effect of 7-ketolithocholic acid on biliary bile acid composition, cholesterol saturation, and as an intermediate in the conversion of chenodeoxycholic acid to ursodeoxycholic acid was investigated in 5 subjects with gallstones. "
07/01/1990 - "When a mixture of [3H]ursodeoxycholic acid and [14C]chenodeoxycholic acid was infused into another bile fistula guinea pig, little 3H could be detected in either chenodeoxycholic acid or 7-ketolithocholic acid. "
03/01/1986 - "Injection of either [14C]cholesterol, [14C]ursodeoxycholic, [14C]7-ketolithocholic acid, or a mixture of [7 beta-3H]chenodeoxycholic acid and [14C]chenodeoxycholic acid into bile fistula nutria demonstrated that all three bile acids can be synthesized hepatically from cholesterol, that they are interconverted sparingly (2%-5%) by the liver, but that 7-ketolithocholic acid is an intermediate in the hepatic transformation of chenodeoxycholic acid to ursodeoxycholic acid. "
|3.||Crohn Disease (Crohn's Disease)
03/01/1986 - "These observations suggest that 7-ketolithocholic acid is an intermediate of this biotransformation in patients with Crohn's disease."
03/01/1986 - "In vivo 7 beta-epimerization of chenodeoxycholic acid to ursodeoxycholic acid and the role of 7-ketolithocholic acid as an intermediate in this biotransformation were studied in 11 patients with Crohn's disease and in 5 healthy volunteers. "
|2.||Ursodeoxycholic Acid (Urso)
|3.||Chenodeoxycholic Acid (Chenix)
|4.||Bile Acids and Salts (Bile Acids)