proelastase
precursor of EC 3.4.21.11, pancreatopeptidase
Networked: 8
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Related Diseases
1. | Pancreatitis
|
2. | Neoplasms (Cancer)
12/01/1991
- " These data suggest that the stenosis or obstruction of the pancreatic duct by cancer probably liberates proelastase 1 from the normal pancreatic acinal cells into the blood. " 12/01/1991
- " The elution profile of all patients with pancreatic head cancer and one of seven patients with pancreatic body-tail cancer with a poststenotic dilatation of the main pancreatic duct showed two peaks: the first was eluted in the position of the alpha 1-AT-E1 complex, and the second was eluted between alpha 1-AT-E1 and elastase 1. The molecular weight of the IRE1 appearing specifically in patients with cancer of the pancreatic head was about 46,000 to 48,000, which was different from the 30,500 molecular weight of (pro)elastase 1. It is possible that proelastase 1 binding with an unknown substance exists in patients with pancreatic cancer. " 12/01/1982
- " We have previously established that secretory proteins from a rat acinar cell tumor lack two forms of procarboxypeptidase B, are deficient in a major lipase species, and possess markedly reduced amounts of the basic proteins proelastase, basic chymotrypsinogen, basic trypsinogen and ribonuclease (Iwanij, V., and J.D. " 12/01/1982
- " Our results indicate that a group of basic polypeptides including proelastase, basic trypsinogen, basic chymotrypsinogen, and ribonuclease, two out of three forms of procarboxypeptidase B, and the major lipase species were greatly reduced or absent in tumor cell secretion. "
|
3. | Necrosis
|
4. | Pneumonia (Pneumonitis)
|
5. | Pancreatic Neoplasms (Pancreatic Cancer)
|
|
Related Drugs and Biologics
Related Therapies and Procedures