anthrone

12/01/2019 - "An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders."

01/01/1995 - "First, SSIn mice, while still retaining a fairly high sensitivity to skin tumor promotion with Chr relative to other inbred strains (i.e., DBA/2, C57BL/6), have lost their increased sensitivity to this anthrone derivative relative to SENCAR mice. "
10/01/1990 - "These latter tumors, not found in the anthrone group, may be indicative of a potentially unique site and/or mechanism of action for this class of compounds."
08/01/1988 - "These latter data, when taken together, suggest a role for oxidation at C10 in skin tumor promotion by anthrone derivatives."
07/15/1987 - "The characteristics of the skin tumor promotion response with anthrone derivatives has been further examined in SENCAR mice. "
01/01/1960 - "Early cancer diagnosis with the Beard anthrone test (Navarro's modification)."

07/15/1987 - "This was due primarily to the fact that similar carcinoma responses were observed in both anthrone- and TPA-treated mice at optimal promoting doses whereas the papilloma responses were significantly lower in the former groups. "
07/15/1987 - "After 60 weeks of promotion, the anthrone promoter-treated groups had carcinoma:papilloma ratios 2.5 to 5.0 times higher than the TPA-treated groups. "
07/15/1987 - "Thus, unlike 12-O-tetradecanoylphorbol-13-acetate (TPA), where a twice weekly application frequency is optimal, application of anthrone promoters such as chrysarobin once weekly is a more optimal frequency for papilloma development. "
06/01/1985 - "Although dose-response comparisons indicated that chrysarobin was several orders of magnitude less potent than TPA for promoting papilloma formation, this anthrone was 1.5 to 2 times more potent than anthralin. "

09/01/2002 - "Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line."
06/01/1990 - "Hypericin is a polycyclic anthrone first isolated from the plant St. Johnswort and was shown to have dramatic anti-retroviral activity against Friend leukemia virus and radiation leukemia virus in mice. "

08/01/2007 - "The hemolysis rate of loaded RBCs was detected by using cyanohemoglobin kit, the intracellular trehalose level were assayed by sulfate anthrone method. "
06/01/2006 - "The morphology of RBCs was observed by light and scanning electron microscopy, the hemolysis rate of loaded RBCs was detected by using cyanohemoglobin kit, the intracellular trehalose levels were assayed by sulfate anthrone method, the intracellular ATP and 2, 3-DPG levels were determined by bioluminescence assay and 2, 3-DPG kit respectively, meanwhile the deformation and osmotic fragility of RBCs were measured. "