Trehalose

07/01/2003 - "During the dehydration process, larvae accumulate large amounts of trehalose, which provides effective protection against desiccation because of its high capacity for water replacement and vitrification. "
01/01/2003 - "As dehydration-induced damage is in correlation with osmotic response recovery and is hindered or buffered by the presence of trehalose, it may be related to water eliminated from biological structures involved in water permeation."
12/14/2009 - "The study also underlines that the characterization of the average phase by conventional XRPD and DSC techniques is not sufficient to describe the dehydration mechanisms of alpha,alpha-trehalose particles. "
04/01/2009 - "In this study, we examined how rates and levels of dehydration alter heat and cold tolerance and how these relate to levels of trehalose within the insect. "
12/04/1997 - "Previous studies on the resistance of yeast cells to dehydration pointed towards the protective role of trehalose and the importance of the specific trehalose transporter in guaranteeing survival. "

04/01/2021 - "It was found that treating dry eye with SH-trehalose leads to greater improvement in the Schirmer's values and TBUT after 8 weeks of sustained use in patients with DED, and this was more pronounced in those with severe DED."
09/01/2009 - "The present study used a novel murine dry eye model induced by controlled low-humidity air velocity to determine whether topically applied trehalose could heal ocular surface epithelial disorders caused by ocular surface desiccation. "
04/01/2021 - "Randomized controlled trial of trehalose: An efficient autophagic bioprotectant in the management of dry eye disease."
01/01/2020 - "Our findings demonstrate that trehalose, functioning as an autophagy enhancer, suppresses the inflammatory response by promoting autophagic flux via TFEB activation in primary HCECs exposed to hyperosmotic stress, a process that is beneficial to dry eye."
01/01/2020 - "The discussion is supplemented with an overview of patents for the use of trehalose in dry eye and with prospects for the 2020s."

01/01/2016 - "This work reports several novel autophagy-lysosome modulators that enhance PGRN expression and identifies trehalose as a promising therapeutic for raising PGRN levels to treat multiple neurodegenerative diseases."
06/01/2023 - "All animal studies on neurodegenerative diseases treated with trehalose published in Medline (accessed via EBSCOhost) and Scopus were considered. "
01/01/2018 - "This review summarizes the fundamental properties of trehalose and the studies on its effects on neurodegenerative diseases. "
09/01/2013 - "In vivo studies with trehalose show cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. "
06/01/2023 - "Profiling neuroprotective potential of trehalose in animal models of neurodegenerative diseases: a systematic review."

06/01/2014 - "Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington's disease."
01/01/2014 - "Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition."
01/01/2009 - "Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease."
01/01/2011 - "Trehalose is under investigation for a number of medical applications, including the treatment of Huntington's chorea and Alzheimer's disease. "
01/01/2017 - "Trehalose induces abundant autophagy in cultured cells and also reduces the rate of aggregation of the huntingtin protein in the animal model of Huntington disease, a chronic neurological disease in humans. "

03/01/2022 - "Trehalose treatment was characterized by an optimal safety profile, but no significant reduction in arterial wall inflammation could be observed. "
01/01/2022 - "Conversely, increasing autophagy with trehalose, decreased inflammation and improved outcomes. "
05/01/2022 - "The results of this study indicated that trehalose prevented inflammation and oxidative stress in the LPS-stimulated PBMCs, providing evidence for the benefits of trehalose as a potential therapeutic agent in inflammatory conditions. "
02/01/2022 - "With the limitations of an in vitro design, our study suggests that in terms of cell response, trehalose-based air-polishing powders show a reduced effect on inflammation."
03/28/2023 - "Trehalose attenuated AAA progression with decreased inflammation and restored SMC contractile phenotype by inducing autophagy. "