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MI192

selective HDAC2-3 inhibitor

Also Known As:

HDAC inhibitor MI192; Histone Deacetylase Inhibitor MI192; N-(2-Aminophenyl)-4-((3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl)benzamide

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Grigg, Ronald: 2 articles (12/2015 - 02/2012)
2.	Al-Griw, Mohamed A: 1 article (07/2021)
3.	Bennour, Emad M: 1 article (07/2021)
4.	Elhensheri, Mohamed M: 1 article (07/2021)
5.	Shmela, Mansur E: 1 article (07/2021)
6.	Demyanenko, S V: 1 article (01/2020)
7.	Nikul, V V: 1 article (01/2020)
8.	Uzdensky, A B: 1 article (01/2020)
9.	Dorfman, Robert Gregory: 1 article (01/2017)
10.	Huang, Shan: 1 article (01/2017)

Related Diseases

1.	Brain Injuries (Brain Injury) 07/01/2021 - "This study aimed to investigate the therapeutic potential of histone deacetylase 2/3 (HDAC2/3) inhibitor MI192 on white matter (WM) pathology in a model of neonatal rat brain injury. "
2.	Stroke (Strokes) 01/01/2020 - "The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain."
3.	Cholangiocarcinoma 01/01/2017 - "However, the role of HDAC3 and the antitumor activity of its inhibitor MI192 are not known in cholangiocarcinoma (CCA). "
4.	Prostatic Neoplasms (Prostate Cancer) 12/15/2015 - "We found that blocking HDAC3 activity using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3. "
5.	Neoplasms (Cancer) 01/01/2017 - "We demonstrated that MI192 can inhibit the deacetylation activity of HDAC3 and its downstream targets in vitro, and MI192 inhibited xenograft tumor growth in vivo. " 01/01/2017 - "MI192 is a novel HDAC3-specific inhibitor that displays antitumor activity in many cancer cell lines. "

Related Drugs and Biologics

1.	Histone Deacetylase 2
2.	Histone Deacetylase Inhibitors
3.	Neuroprotective Agents
4.	Cytokines
5.	Tubulin
6.	Histone Deacetylases (Histone Deacetylase)
7.	theasinensin A
8.	trichostatin A (A 300)