tirbanibulin

03/16/2022 - "Comparative Efficacy and Safety of Tirbanibulin for Actinic Keratosis of the Face and Scalp in Europe: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials."
05/01/2023 - "Economic Evaluation of Tirbanibulin for the Treatment of Actinic Keratosis in Scotland."
01/01/2023 - "Line-field confocal optical coherence tomography in the treatment monitoring of actinic keratosis with tirbanibulin: A pilot study."
10/01/2022 - "Profile of Tirbanibulin for the Treatment of Actinic Keratosis."
07/01/2022 - "Tirbanibulin for the Treatment of Actinic Keratosis: A Review."

07/01/2017 - "KX-01 effectively inhibited the growth of breast cancer cell lines. "
04/01/2012 - "Combinations of KX-01 with endocrine therapy present a promising new strategy for clinical management of ERα positive breast cancer."
09/01/2012 - "KX-01 is a potently active Src/pretubulin inhibitor that inhibits breast tumor growth and metastasis. "
04/01/2012 - "The present study was designed to evaluate the effects of KX-01 as a single agent and in combination with tamoxifen (TAM) on cell growth and apoptosis of ERα positive breast cancer in vitro and in vivo. "
07/01/2017 - "Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome the therapeutic limitations of current Src inhibitors through inhibition of both Src and tubulin. "

01/01/2021 - "Overall, these findings revealed that KX-01 can alleviate experimental pulmonary fibrosis via suppressing the p-SRC/p-STAT3 signaling pathways."
01/01/2021 - "Tirbanibulin Attenuates Pulmonary Fibrosis by Modulating Src/STAT3 Signaling."
01/01/2021 - "In BLM-induced pulmonary fibrosis rats, KX-01 reduced pathological scores, collagen deposition, α-SMA, collagen I, collagen III, p-Src, HIF-1α, and p-STAT3. "
01/01/2021 - "This study assessed the impact of KX-01 on cobalt chloride (CoCl2)-treated L929 cells and bleomycin (BLM)-induced pulmonary fibrosis in rats to evaluate the efficacy of this compound in vitro and in vivo, respectively. "

04/01/2022 - "Human papillomavirus 57 positivity in periungual squamous cell carcinoma eradicated by topical tirbanibulin."
10/01/2023 - "Real-world experience with histological confirmation of clinical response of squamous cell carcinoma to topical tirbanibulin."
08/01/2021 - "Topical tirbanibulin eradication of periungual squamous cell carcinoma."
11/01/2021 - "The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, a precursor of squamous-cell carcinoma. "

07/01/2017 - "The antitumor effect of KX-01 in triple negative breast cancer (TNBC) cell lines was determined by MTT assay. "
11/01/2017 - ": Src kinase/pretubulin inhibitor KX-01 restores functional ERα expression in ERα- breast tumors, a novel treatment strategy to treat triple-negative breast cancer. "