Optate

an inhaled isotonic, isosmotic, alkaline glycine solution designed to safely modify airway pH

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Islam, Mahmuda: 1 article (09/2021)
2.	Khan, Md Ariful Islam: 1 article (09/2021)
3.	Noor Ali Khan, Mohammad Abu Hadi: 1 article (09/2021)
4.	Pervin, Munmun: 1 article (09/2021)
5.	Sultana, Nazneen: 1 article (09/2021)
6.	Sultana, Sajeda: 1 article (09/2021)
7.	Clemente, Tatiana M: 1 article (01/2021)
8.	Cunningham, Rebekah S: 1 article (01/2021)
9.	Davis, Michael D: 1 article (01/2021)
10.	Gaston, Benjamin: 1 article (01/2021)

1.	Infections 07/01/2023 - "We aimed to determine whether raising intracellular pH with Optate would decrease infection and replication of RSV in primary HAECs. " 09/01/2021 - "The park C deer may optate infection from companion man and animals living around. " 07/01/2023 - "We infected HAECs with green fluorescent protein-labelled RSV (GFP-RSV; multiplicity of infection=1) and treated them with Optate or PBS control. " 01/01/2021 - "Cells were pretreated with Optate or placebo prior to infection (multiplicity of infection = 1), and viral replication was determined with plaque assay and nucleocapsid (N) protein levels. "
2.	Respiratory Syncytial Virus Infections 07/01/2023 - "Optate inhibits RSV infection in primary HAECs in a dose-dependent manner. " 07/01/2023 - "Additionally, RSV infection decreased as Optate concentration increased in a dose-dependent manner (p<0.001). "
3.	Virus Diseases (Viral Diseases) 01/01/2021 - "We grew primary NHAE cells from healthy subjects, infected them with SARS-CoV-2 (isolate USA-WA1/2020), and used clinical Optate at concentrations used in humans in vivo to determine whether Optate would prevent viral infection and replication. "
4.	COVID-19 01/01/2021 - "Inhaled Optate may be well suited for a clinical trial in patients with pulmonary SARS-CoV-2 infection. "