tris-O-tolyphosphine (TOTP)

04/10/1989 - "All birds were dosed with 500 mg TOTP/kg body weight and killed after post-exposure periods of 1, 2, 3, or 4 weeks. "
01/01/1989 - "Small amounts of axonal degeneration were noted in the dorsolateral part of the lateral funiculus and in the fasciculus gracilis of spinal cords in ferrets receiving dermal doses of 1000 mg TOTP/kg body weight. "
01/01/1989 - "Of the animals dosed orally, only those in the 1000 mg TOTP/kg body weight group showed clinical signs indicative of OPIDN. "
01/01/1988 - "In addition, TOTP TSP were administered intravenously at 250 and 50 mg/kg body weight, respectively. "
01/01/1989 - "Ferrets administered 250 and 500 mg TOTP/kg body weight via the dermal route displayed variable degrees of hind limb weakness and ataxia. "

05/14/1999 - "In contrast, 10(-6) M RLM-activated TOTP produced more inhibition of hen brain NTE (89 +/- 6%) than NTE of human neuroblastoma cells (72 +/- 7%). "
05/14/1999 - "Only preincubation with RLM activated TOTP; resultant inhibition of AChE was less in hen brain (13 +/- 3%) than in neuroblastoma cells (73 +/- 1%) at 10(-6) M. "
06/01/1980 - "In this study neuroblastoma 2-A cells, a homogenous cell system which exhibits many of the functional properties of normal neurons, was used to establish dose-response relationships of three organophosphorus compounds: Tri-o-tolyl-phosphate (TOTP), Diisopropylfluorophosphate (DFP) and dicrotophos. "
10/01/1999 - "This was done by measuring the changes in DeltaPsi(m) in SH-SY5Y human neuroblastoma cells incubated with the cationic fluorochrome, rhodamine 123 (5 microg/ml), and the OP compounds tri-ortho-tolyl phosphate (TOTP), triphenyl phosphite (TPPi), or parathion for 7.5 to 960 minutes. "
12/01/2001 - "We, therefore, investigated changes in f-actin in SH-SY5Y human neuroblastoma cells exposed to 0.1 and 1 mM paraoxon, parathion, phenyl saligenin phosphate (PSP), tri-ortho-tolyl phosphate (TOTP), triphenyl phosphite (TPPi), and di-isopropyl phosphorofluoridate (DFP) for 0-48 h. "

04/01/1992 - "Noise stress did not affect TOTP-induced ataxia. "
01/01/1988 - "The TOTP-treated birds manifested locomotor deficit by 15 days postdosing and exhibited T2-T4 ataxia at maximal locomotor impairment. "
01/01/1989 - "Ferrets administered 250 and 500 mg TOTP/kg body weight via the dermal route displayed variable degrees of hind limb weakness and ataxia. "
10/01/1984 - "In hens at 1,2, and 4 weeks following treatment with TOTP, the average amount of posttetanic potentiation was reduced concomitantly with the development of ataxia, paralysis, and pathological changes in the peripheral nerves. "
04/01/1983 - "In both the Japanese quail and bobwhite, all doses of TOTP resulted in NTE inhibition in excess of 70%, yet no birds of either species developed ataxia or paralysis. "

01/01/1977 - "Whole-body gamma-irradiation up to 1020 roentgens failed to show any consistent protection from the TOTP induced paralysis. "
10/01/1984 - "In hens at 1,2, and 4 weeks following treatment with TOTP, the average amount of posttetanic potentiation was reduced concomitantly with the development of ataxia, paralysis, and pathological changes in the peripheral nerves. "
04/01/1983 - "In both the Japanese quail and bobwhite, all doses of TOTP resulted in NTE inhibition in excess of 70%, yet no birds of either species developed ataxia or paralysis. "
01/01/1995 - "Oral doses of TOTP resulted in no detectable clinical signs while injections of TPP resulted in mild ataxia to severe paralysis depending upon the dosage level. "

04/01/2008 - "In vivo, the ratio of phosphomonoester/total phosphorus (TotP) signal was significantly increased in LAQ824-treated HT29 xenografts, and this ratio was inversely correlated with changes in tumor volume. "
04/01/2008 - "Statistically significant decreases in intracellular pH, beta-nucleoside triphosphate (beta-NTP)/TotP, and beta-NTP/inorganic phosphate (Pi) and an increase in Pi/TotP were also seen in LAQ824-treated tumors. "
10/01/2004 - "The inhibitory effect of CBDP, HO-TOTP, and 3-BCP on FAEE synthase and esterase activity was studied using rat hepatic and pancreatic postnuclear (PN) fractions, commercial porcine hepatic CE and pancreatic ChE, and in HepG2 and rat pancreatic tumor (AR42J) cell lines. "