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SZC017

synthetic antineoplastic; structure in first source

Also Known As:

2-(piperidine-1-methyl)-3-oxo-olean-12-en-28-oic acid

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Oleanolic Acid: 547
        SZC017: 4
      - Sapogenins: 26
        Oleanolic Acid: 547
        SZC017: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - SZC017: 4

Experts

1.	Gao, Lei: 3 articles (12/2017 - 12/2015)
2.	Lin, Yuan: 3 articles (12/2017 - 12/2015)
3.	Peng, Jinyong: 3 articles (12/2017 - 12/2015)
4.	Sun, Bin: 3 articles (12/2017 - 12/2015)
5.	Tang, Zeyao: 3 articles (12/2017 - 12/2015)
6.	Wang, Shisheng: 3 articles (12/2017 - 12/2015)
7.	Chu, Peng: 2 articles (12/2017 - 12/2015)
8.	Han, Guozhu: 2 articles (02/2016 - 12/2015)
9.	Wang, Yan: 2 articles (02/2016 - 12/2015)
10.	Xu, Zhen: 2 articles (02/2016 - 12/2015)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 02/01/2016 - "Taken together, our data indicate that SZC017 may be a potential chemotherapeutic agent against gastric cancer cells." 02/01/2016 - "Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells." 02/01/2016 - "Mechanistically, SZC017 was effective against gastric cancer cells via inhibiting Akt/NF‑κB signaling and topoisomerase I and IIα proteins. "
2.	Neoplasms (Cancer) 01/01/2022 - "Some of these derivatives, such as CDDO (2-cyano-3,12-dioxooleana-1, 9 (11)-dien-28-oic acid) have been verified in clinical trials, while other derivatives studied previously, such as SZC014, SZC015 and SZC017 (OA derivatives respectively), are also candidate drugs for cancer treatment. "
3.	Lung Neoplasms (Lung Cancer) 12/01/2017 - "In summary, our study provides pharmacological evidence that SZC017 exhibits potential use in the treatment of lung cancer." 12/01/2017 - "In the present study, we aimed to investigate the cytotoxic effect and the underlying mechanisms of SZC017, an oleanolic acid derivative, on human lung cancer cells. " 12/01/2017 - "Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells."
4.	Breast Neoplasms (Breast Cancer) 12/01/2015 - "We found that SZC017 effectively decreased the cell viability of these breast cancer cells, but was less toxic to MCF10A mammary epithelial cells. " 12/01/2015 - "SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells." 12/01/2015 - "Additionally, pretreatment with N-acetyl-L-cysteine (NAC), a ROS scavenger, increased cell viability and the expression of Akt and procaspase-3, but decreased the ratio of LC3-II/I. These data show that SZC017 is an effectively selective anticancer agent against breast cancer cells, highlighting the potential use of this derivative as a breast cancer therapeutic agent. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Type I DNA Topoisomerases (Topoisomerase I)
3.	Oleanolic Acid
4.	bardoxolone
5.	2- (pyrrolidine- 1- yl)methyl- 3- oxoolean- 12- en- 28- oic acid
6.	2- morpholinomethyl- 3- oxoolean- 12- en- 28- oic acid
7.	Caspase 3 (Caspase-3)
8.	Antineoplastic Agents (Antineoplastics)
9.	Acetylcysteine (Siran)