Nedd4 Ubiquitin Protein Ligases

E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

Also Known As:

Nedd4 Proteins; Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase; Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase

Macromolecular Substances: 97
- Multiprotein Complexes: 128
  - Endosomal Sorting Complexes Required for Transport: 191
    - Nedd4 Ubiquitin Protein Ligases
Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Ligases: 5708
    - Ubiquitin-Protein Ligase Complexes
      - Ubiquitin-Protein Ligases: 3625
        Nedd4 Ubiquitin Protein Ligases
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Vesicular Transport Proteins: 1
      - Endosomal Sorting Complexes Required for Transport: 191
        Nedd4 Ubiquitin Protein Ligases

Drosophila Nedd4 protein

Bio-Agent Context: Research Results