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2- ((4- methylphenyl)sulfonyl)- 5- nitrofuran

a Ubc13 inhibitor; structure in first source

Also Known As:

NSC697923

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 2-((4-methylphenyl)sulfonyl)-5-nitrofuran: 6
- Nitro Compounds: 66
  - Nitrofurans: 69
    - 2-((4-methylphenyl)sulfonyl)-5-nitrofuran: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - Nitrofurans: 69
      - 2-((4-methylphenyl)sulfonyl)-5-nitrofuran: 6

Experts

1.	Barozzino, Mariagrazia: 2 articles (05/2021 - 01/2018)
2.	Castellano, Giuseppe: 2 articles (05/2021 - 01/2018)
3.	Conserva, Francesca: 2 articles (05/2021 - 01/2018)
4.	Divella, Chiara: 2 articles (05/2021 - 01/2018)
5.	Gallone, Anna: 2 articles (05/2021 - 01/2018)
6.	Gesualdo, Loreto: 2 articles (05/2021 - 01/2018)
7.	Giorgino, Francesco: 2 articles (05/2021 - 01/2018)
8.	Pontrelli, Paola: 2 articles (05/2021 - 01/2018)
9.	Simone, Simona: 2 articles (05/2021 - 01/2018)
10.	Cao, Dong-Yi: 1 article (01/2022)

Related Diseases

1.	Hyperglycemia 01/01/2018 - "In vitro, we confirmed a tight association between impaired autophagy, Lys63-Ub, and apoptosis since Lys63-Ub inhibition by NSC697923 abrogated HG-induced cell death and LC3 silencing also blocked hyperglycemia-induced caspase-3 activation. " 01/01/2018 - "Hyperglycemia (HG) induced LC3 and p62 protein expression in HK2 cells together with Lys63-ubiquitinated proteins, and the inhibition of HG-induced Lys63-Ub by NSC697923 inhibitor, significantly reduced both LC3 and p62 expression. " 05/14/2021 - "NSC697923, both alone and in association with ramipril, in vitro and in vivo inhibited hyperglycemia-induced epithelial to mesenchymal transition by significantly reducing K63-Ub proteins, α-SMA, collagen I, vimentin, FSP-1 expression, and collagen III along with tubulointerstitial and glomerular fibrosis. "
2.	Gouty Arthritis 01/01/2022 - "In an animal model of gouty arthritis, NSC697923 effectively inhibited joint swelling, IL-1β release, and NLRP3 inflammasome activation. "
3.	Neoplasms (Cancer) 02/20/2014 - "In p53 wild-type NB cells, NSC697923 induced nuclear accumulation of p53, which led to its increased transcriptional activity and tumor suppressor function. "
4.	Melanoma (Melanoma, Malignant) 11/15/2018 - "Systemic delivery of NSC697923, a small-molecule inhibitor of UBE2N, significantly decreased melanoma xenograft growth. "
5.	Fibrosis (Cirrhosis) 05/14/2021 - "NSC697923, both alone and in association with ramipril, in vitro and in vivo inhibited hyperglycemia-induced epithelial to mesenchymal transition by significantly reducing K63-Ub proteins, α-SMA, collagen I, vimentin, FSP-1 expression, and collagen III along with tubulointerstitial and glomerular fibrosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Inflammasomes
3.	Caspase 3 (Caspase-3)
4.	Ramipril (Altace)
5.	Vimentin
6.	Collagen