N-adamantyl-4-methylthiazol-2-amine

structure in first source

Also Known As:

KHG26693

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        N-adamantyl-4-methylthiazol-2-amine: 5
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        N-adamantyl-4-methylthiazol-2-amine: 5
- Sulfur Compounds: 278
  - Thiazoles: 392
    - N-adamantyl-4-methylthiazol-2-amine: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - N-adamantyl-4-methylthiazol-2-amine: 5

Experts

1.	Cho, Sung-Woo: 5 articles (11/2020 - 08/2014)
2.	Kim, Eun-A: 4 articles (11/2020 - 08/2014)
3.	Choi, Soo Young: 3 articles (11/2020 - 09/2014)
4.	Yang, Seung-Ju: 3 articles (11/2020 - 08/2014)
5.	Han, A Reum: 2 articles (11/2020 - 09/2014)
6.	Kim, Jiae: 2 articles (07/2017 - 12/2015)
7.	Ahn, Jee-Yin: 2 articles (12/2015 - 09/2014)
8.	Hahn, Hoh-Gyu: 2 articles (12/2015 - 08/2014)
9.	Choi, Hye-Rim: 1 article (11/2020)
10.	Hwang, Kyouk: 1 article (11/2020)

Related Diseases

1.	Inflammation (Inflammations) 12/15/2015 - "Although the clinical relevance of our findings remains to be determined, our data suggest that KHG26693 might prevent neuronal cell injury via the reduction of inflammation and oxidative stress in the brain. " 07/01/2017 - "N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain." 09/01/2014 - "The present study investigated the effects of a new compound, N-adamantyl-4-methylthiazol-2-amine (KHG26693), against lipopolysaccharide (LPS)-induced inflammation in cultured BV-2 microglial cells. " 11/01/2020 - "We recently reported that N-adamantyl-4-methylthiazol-2-amine (KHG26693) attenuates glutamate-induced oxidative stress and inflammation in the brain. "
2.	Diabetes Mellitus 08/05/2014 - "In our present study, we investigated the anti-inflammatory and antioxidant properties of N-adamantyl-4-methylthiazol-2-amine (KHG26693), a new thiazole derivative, in a streptozotocin (STZ)-induced model of diabetes mellitus. "
3.	Hyperlipidemias (Hyperlipidemia) 08/05/2014 - "Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats."
4.	Hyperglycemia 08/05/2014 - "Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats."
5.	Encephalitis (Encephalitis, Rasmussen) 12/15/2015 - "N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice." 12/15/2015 - "In this LPS-induced model of brain inflammation, administration of KHG26693 effectively prevented increases in the levels of IL-1β, TNF-α, prostaglandin E2, malondialdehyde, and nitric oxide, and mitigated reductions in the levels of superoxide dismutase in the hippocampus. " 12/15/2015 - "We report that N-adamantyl-4-methylthiazol-2-amine (KHG26693), a novel thiazole derivative, can prevent lipopolysaccharide (LPS)-induced brain inflammation in mice. "

Related Drugs and Biologics

1.	N-adamantyl-4-methylthiazol-2-amine
2.	Thiazoles
3.	Lipopolysaccharides
4.	Streptozocin (Streptozotocin)
5.	Antioxidants
6.	Glutamic Acid (Glutamate)
7.	Dinoprostone (PGE2)
8.	Superoxide Dismutase
9.	Nitric Oxide (Nitrogen Monoxide)
10.	Malondialdehyde (Propanedial)