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brevipolide H

from Hyptis brevipes; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopropanes: 9
        brevipolide H: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Pyrones: 35
      - brevipolide H: 1

Experts

1.	Chen, Ching-Nung: 1 article (06/2020)
2.	Guh, Jih-Hwa: 1 article (06/2020)
3.	Hou, Duen-Ren: 1 article (06/2020)
4.	Hsu, Jui-Ling: 1 article (06/2020)
5.	Hsu, Lih-Ching: 1 article (06/2020)
6.	Leu, Wohn-Jenn: 1 article (06/2020)
7.	Liu, Ying-Tung: 1 article (06/2020)
8.	Sheng, Yi-Hua: 1 article (06/2020)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 06/25/2020 - "The (+)-Brevipolide H also induced the downregulation of anti-apoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xL) and loss of mitochondrial membrane potential, indicating the contribution of mitochondrial dysfunction to apoptosis. " 06/25/2020 - "In addition, suppression of Akt/mTOR/p70S6K pathway associated with downregulation of G1 phase cyclins contributes to (+)-brevipolide H-mediated anticancer activity, which ultimately causes mitochondrial dysfunction and cell apoptosis. "
2.	Prostatic Neoplasms (Prostate Cancer) 06/25/2020 - "The (+)-brevipolide H, an α-pyrone-based natural compound, induced potent and long-term anticancer effects in human castration-resistant prostate cancer (CRPC) PC-3 cells. " 06/25/2020 - "The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis."

Related Drugs and Biologics

1.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
2.	Cyclins
3.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Castration