70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

Also Known As:

Networked: 925 relevant articles (43 outcomes, 100 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Katta, Anjaiah: 6 articles (01/2012 - 01/2009)
2.	Wu, Miaozong: 6 articles (01/2012 - 01/2009)
3.	Pei, Jin-Jing: 6 articles (11/2008 - 08/2003)
4.	Wong, Alice S T: 5 articles (01/2022 - 05/2006)
5.	Wang, Wei: 5 articles (10/2021 - 04/2012)
6.	Tian, Hui: 5 articles (10/2021 - 01/2016)
7.	Hou, Guiqin: 5 articles (01/2021 - 08/2007)
8.	Liu, Lei: 5 articles (01/2018 - 02/2009)
9.	Maiese, Kenneth: 5 articles (12/2014 - 01/2012)
10.	Blough, Eric R: 5 articles (01/2012 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "At the doses employed, MPL was modestly effective at suppressing tumor growth, but highly effective in inhibiting, mTOR, P70S6K and 4EBP1. " 01/01/2022 - "The present study demonstrates that AKH markedly inhibits the growth and induces autophagy‑related apoptosis in cancer cells by regulating the AMPK and Akt/mTOR/p70S6K signaling pathways. " 06/01/2015 - "The primary objective of this phase I study of LY2780301, a dual p70 S6 kinase and Akt inhibitor, was to determine the recommended phase II dose as a single agent in patients with advanced cancer. " 06/01/2015 - "A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer." 10/31/2023 - "We found that TAS0612 is a potent, orally available compound that can inhibit p90RSK (RSK), AKT, and p70S6K (S6K) as a single agent and showed a strong correlation with the growth inhibition of cancer cells with PTEN loss or mutations, regardless of the presence of KRAS and BRAF mutations. "
2.	Fibrosis (Cirrhosis) 01/01/2017 - "Moreover, Shh protected skeletal muscle against I/R injury by alleviating muscle destruction, reducing interstitial fibrosis and inhibiting apoptosis, and these protective effects were abrogated when the AKT/mTOR/p70S6K pathway was inhibited. " 01/01/2020 - "Our findings suggest that RXR agonist ameliorates STZ-induced DCM by inhibiting myocardial fibrosis via modulation of the LKB1/p70S6K signaling pathway. " 01/02/2018 - "CONCLUSIONS Our study suggests that HGF treatment significantly attenuates the development of EndMT induced by TGF-β1 via the TGFb/Smad and Akt/mTOR/P70S6K signaling, which provides novel insights into the prevention and treatment of interstitial fibrosis and CAD following renal transplant." 01/01/2022 - "These findings were validated in vivo as p70S6K-/- mice developed significantly less fibrosis upon exposure to CCl4. " 12/01/2019 - "In summary, these data suggest that Tan IIA alleviates SSc-related dermal fibrosis and EndoMT and that the Akt/mTOR/p70S6K signaling pathway is involved in this regulation, thus supporting the potential of Tan IIA as a disease-modifying candidate agent for treating the vascular damage of SSc."
3.	Insulin Resistance 12/01/2009 - "Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats." 09/15/2009 - "The results of a recent study conducted by our group indicate that hypothalamic insulin resistance via p70 S6 kinase 1 (S6K1) activation induced by a high-fat diet may explain this discrepancy between physiological and biochemical observations. " 01/01/2018 - "These substrates included the p70S6K substrates RPS6 and IRS1, which suggested cross talk between PKCε and p70S6K in high-fat diet-induced hepatic insulin resistance. " 07/01/2013 - "Whether the decrease in AMPK activity is causal to the events leading to insulin resistance (increased mTOR/p70S6K signaling) remains to be determined. " 05/25/2012 - "Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance."
4.	Lung Neoplasms (Lung Cancer) 11/01/2022 - "Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1." 11/01/2022 - "Correction to: Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1." 11/16/2018 - "Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. " 09/01/2017 - "Ginkgo biloba exocarp extracts induces autophagy in Lewis lung cancer cells involving AMPK / mTOR / p70S6k signaling pathway." 01/01/2017 - "Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway."
5.	Cognitive Dysfunction 01/01/2019 - "These results indicate that NC ameliorates DM-induced cognitive function impairment via restoring autophagic flux might by inhibiting mTOR/p70S6k activation in the CA1 region, and NC may be a promising agent for diabetic cognitive dysfunction prevention and treatment." 01/01/2021 - "Rifampicin ameliorates cognitive impairment by suppression of Aβ1-42 accumulation through inhibition of Akt/mTOR/p70S6K signaling and enhancement of autophagy in the hippocampus of LPS-induced mice." 01/01/2022 - "However, the involvement of the mTOR/P70S6K pathway in zinc-induced oxidative stress, tau degeneration, and synaptic and cognitive impairment has not been fully elucidated in vivo. " 02/01/2021 - "These findings imply that rapamycin prevents cognitive impairment and protects hippocampus neurons from AD-like pathology and mitochondrial abnormality, and also that rapamycin treatment could normalize these STZ-induced alterations by decreasing hippocampus mTOR/p70S6K hyperactivity." 02/01/2021 - "Rapamycin, an inhibitor of mTOR, rescued the STZ-induced increases in mTOR/p70S6K activities, tau phosphorylation and Aβ levels, as well as mitochondria abnormality and cognitive impairment in mice. "

Related Drugs and Biologics

1.	Sirolimus (Rapamycin)
2.	Mechanistic Target of Rapamycin Complex 1
3.	Proteins (Proteins, Gene)
4.	tanshinone
5.	Bleomycin (Blenoxane)
6.	Ribosomal Protein S6 Kinases (S6 Kinase)
7.	Paclitaxel (Taxol)
8.	MTOR Inhibitors
9.	amitraz (Taktic)
10.	Phosphatidylinositols (Phosphatidylinositol)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ischemic Postconditioning
4.	Immunotherapy
5.	Castration